Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer’s Disease Pathogenesis in Cell and Animal Models

Protein Phosphatase 2A Reduces Cigarette Smoke-Induced Cathepsin S and Loss of Lung Function

(2019) Declan F Doherty et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular Targeting

(2019) Yao Zhang et al.   Neuroscience Bulletin

Elevation of pS262-Tau and Demethylated PP2A in Retina Occurs Earlier than in Hippocampus During Hyperhomocysteinemia

(2019) Jing Guo et al.   JOURNAL OF ALZHEIMERS DISEASE

The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction

(2019) Ryan M. De Palma et al.   FASEB JOURNAL

Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild to Moderate Alzheimer’s Disease: The OmegAD Study

(2019) Fredrik Jernerén et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic Cigarette Smoke Exposure Subdues PP2A Activity by Enhancing Expression of the Oncogene CIP2A

(2018) Sridesh Nath et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Emerging roles of microglial cathepsins in neurodegenerative disease

(2018) Jessica R. Lowry et al.   BRAIN RESEARCH BULLETIN

Non-genomic mechanisms of protein phosphatase 2A (PP2A) regulation in cancer

(2018) Otto Kauko et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Therapeutic targeting of PP2A

(2018) Caitlin M. O’Connor et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Homocysteine Increases Tau Phosphorylation, Truncation and Oligomerization

(2018) Norimichi Shirafuji et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Moringa Oleifera Alleviates Homocysteine-Induced Alzheimer’s Disease-Like Pathology and Cognitive Impairments

(2018) Yacoubou Abdoul Razak Mahaman et al.   JOURNAL OF ALZHEIMERS DISEASE

CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer’s Disease

(2018) Yang-Ping Shentu et al.   Cell Reports

Folate/vitamin-B12 Prevents Chronic Hyperhomocysteinemia-Induced Tau Hyperphosphorylation and Memory Deficits in Aged Rats

(2018) Wei Wei et al.   JOURNAL OF ALZHEIMERS DISEASE

Novel Multipotent AChEI-CCB Attenuates Hyperhomocysteinemia-Induced Memory Deficits and Neuropathologies in Rats

(2018) Yiyuan Xia et al.   JOURNAL OF ALZHEIMERS DISEASE

Folate/Vitamin B Alleviates Hyperhomocysteinemia-Induced Alzheimer-Like Pathologies in Rat Retina

(2018) Jing Guo et al.   Neuroscience Bulletin

Methanolic extract of Tamarix Gallica attenuates hyperhomocysteinemia induced AD-like pathology and cognitive impairments in rats

(2018) Maibouge Tanko Mahamane Salissou et al.   Aging-US

Emodin Rescued Hyperhomocysteinemia-Induced Dementia and Alzheimer’s Disease-Like Features in Rats

(2018) Peng Zeng et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer’s disease Neurons

(2017) Ravi Rajmohan et al.   JOURNAL OF ALZHEIMERS DISEASE

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

(2017) Jaya Sangodkar et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of microtubule-associated protein tau phosphorylation in Alzheimer’s disease

(2017) Rong-hong Ma et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

BACE1 Cleavage Site Selection Critical for Amyloidogenesis and Alzheimer's Pathogenesis

(2017) Shuting Zhang et al.   JOURNAL OF NEUROSCIENCE

Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony

(2017) Stefania Forner et al.   TRENDS IN NEUROSCIENCES

PP2A-B′ holoenzyme substrate recognition, regulation and role in cytokinesis

(2017) Cheng-Guo Wu et al.   Cell Discovery

NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease

(2016) Viviana Triaca et al.   AGING CELL

Phosphatase PP2A is requisite for the function of regulatory T cells

(2016) Sokratis A Apostolidis et al.   NATURE IMMUNOLOGY

Homocysteinemia and early outcome of acute ischemic stroke in elderly patients

(2016) Paola Forti et al.   Brain and Behavior

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

A novel tacrine-dihydropyridine hybrid (-)SCR1693 induces tau dephosphorylation and inhibits Aβ generation in cells

(2015) Xiu-Lian Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Zinc binds to and directly inhibits protein phosphatase 2A in vitro

(2015) Yan Xiong et al.   Neuroscience Bulletin

Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles

(2014) Jian-Guo Li et al.   ANNALS OF NEUROLOGY

Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies

(2014) Pradip K. Kamat et al.   MOLECULAR NEUROBIOLOGY

Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease

(2014) Gustavo Basurto-Islas et al.   NEUROBIOLOGY OF AGING

Tau hyperphosphorylation induces apoptotic escape and triggers neurodegeneration in Alzheimer’s disease

(2014) Jian-Zhi Wang et al.   Neuroscience Bulletin

FTY720 (Fingolimod) Attenuates Beta-amyloid Peptide (Aβ42)-Induced Impairment of Spatial Learning and Memory in Rats

(2013) Masoumeh Asle-Rousta et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine

(2012) Gao-Shang Chai et al.   JOURNAL OF NEUROCHEMISTRY

APOE-Mimetic Peptides Reduce Behavioral Deficits, Plaques and Tangles in Alzheimer’s Disease Transgenics

(2012) M.P. Vitek et al.   Neurodegenerative Diseases

Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer’s disease

(2011) Michael Voronkov et al.   Future Medicinal Chemistry

Increased inflammatory markers in brain and blood of rats subjected to acute homocysteine administration

(2010) Aline A. da Cunha et al.   METABOLIC BRAIN DISEASE

PR65, the HEAT-repeat scaffold of phosphatase PP2A, is an elastic connector that links force and catalysis

(2010) A. Grinthal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

(2010) J. van Eersel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

SV40 small T antigen and PP2A phosphatase in cell transformation

(2008) Anna A. Sablina et al.   CANCER AND METASTASIS REVIEWS

Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus

(2007) Chang-E. Zhang et al.   NEUROBIOLOGY OF AGING