Updating osteoimmunology: regulation of bone cells by innate and adaptive immunity

Homeostatic Immunity and the Microbiota

(2017) Yasmine Belkaid et al.   IMMUNITY

The case for periodontitis in the pathogenesis of rheumatoid arthritis

(2017) Jan Potempa et al.   Nature Reviews Rheumatology

Microbiota, Immune Subversion, and Chronic Inflammation

(2017) Carolyn D. Kramer et al.   Frontiers in Immunology

The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts

(2017) Hyunsoo Kim et al.   Scientific Reports

The osteoimmunology of alveolar bone loss

(2016) Kevin A. Tompkins   CONNECTIVE TISSUE RESEARCH

Osteoimmunology and Beyond

(2016) Lia Ginaldi et al.   CURRENT MEDICINAL CHEMISTRY

IL-1β at the crossroad between rheumatoid arthritis and type 2 diabetes: may we kill two birds with one stone?

(2016) Roberto Giacomelli et al.   Expert Review of Clinical Immunology

Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency

(2016) Asuka Terashima et al.   IMMUNITY

The Lyme Disease Pathogen Borrelia burgdorferi Infects Murine Bone and Induces Trabecular Bone Loss

(2016) Tian Tian Tang et al.   INFECTION AND IMMUNITY

RANKL (Receptor Activator of NFκB Ligand) Produced by Osteocytes Is Required for the Increase in B Cells and Bone Loss Caused by Estrogen Deficiency in Mice

(2016) Yuko Fujiwara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Links Between the Microbiome and Bone

(2016) Christopher J Hernandez et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics

(2016) Jau-Yi Li et al.   JOURNAL OF CLINICAL INVESTIGATION

A microbial perspective of human developmental biology

(2016) Mark R. Charbonneau et al.   NATURE

How the microbiota shapes rheumatic diseases

(2016) Tom Van de Wiele et al.   Nature Reviews Rheumatology

Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis

(2016) Anca I. Catrina et al.   Nature Reviews Rheumatology

Gut microbiota induce IGF-1 and promote bone formation and growth

(2016) Jing Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of bone and cartilage by adenosine signaling

(2016) Lauren C. Strazzulla et al.   Purinergic Signalling

Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition

(2016) M. Schwarzer et al.   SCIENCE

The National Institutes of Health Human Microbiome Project

(2016) Lita M. Proctor   Seminars in Fetal & Neonatal Medicine

RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation

(2015) Lynett Danks et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss

(2015) Akilan Krishnamurthy et al.   ANNALS OF THE RHEUMATIC DISEASES

Granulocyte colony-stimulating factor reprograms bone marrow stromal cells to actively suppress B lymphopoiesis in mice

(2015) R. B. Day et al.   BLOOD

A Comprehensive Review of Immunoreceptor Regulation of Osteoclasts

(2015) Mary Beth Humphrey et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The Role of Microbiota on the Gut Immunology

(2015) Yang Won Min et al.   CLINICAL THERAPEUTICS

A comprehensive review of denosumab for bone metastasis in patients with solid tumors

(2015) Gözde Gül et al.   CURRENT MEDICAL RESEARCH AND OPINION

Denosumab for the treatment of osteoporosis

(2015) Sarah Zaheer et al.   Expert Opinion on Drug Metabolism & Toxicology

NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms

(2015) Chao Qu et al.   FASEB JOURNAL

Arthritogenic T cells in autoimmune arthritis

(2015) Noriko Komatsu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Host response mechanisms in periodontal diseases

(2015) Nora SILVA et al.   Journal of Applied Oral Science

Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow

(2015) Vionnie W.C. Yu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Use of Germ-Free Animal Models in Microbiota-Related Research

(2015) Maha Al-Asmakh et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Immune complexes regulate bone metabolism through FcRγ signalling

(2015) Takako Negishi-Koga et al.   Nature Communications

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

(2015) Ulrike Harre et al.   Nature Communications

Osteoimmunology: Major and Costimulatory Pathway Expression Associated with Chronic Inflammatory Induced Bone Loss

(2015) Tania N. Crotti et al.   Journal of Immunology Research

The oral microbiome and the immunobiology of periodontal disease and caries

(2014) Massimo Costalonga et al.   IMMUNOLOGY LETTERS

Impact of the Oral Commensal Flora on Alveolar Bone Homeostasis

(2014) K. Irie et al.   JOURNAL OF DENTAL RESEARCH

Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss

(2014) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purinergic signalling and immune cells

(2014) Geoffrey Burnstock et al.   Purinergic Signalling

Killing two birds with one stone: trans-kingdom suppression of PAMP/MAMP-induced immunity by T3E from enteropathogenic bacteria

(2014) Malou Fraiture et al.   Frontiers in Microbiology

Bone and the Innate Immune System

(2014) Julia F. Charles et al.   Current Osteoporosis Reports

Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond

(2014) Matthew C. Walsh et al.   Frontiers in Immunology

Matrix-Embedded Osteocytes Regulate Mobilization of Hematopoietic Stem/Progenitor Cells

(2013) Noboru Asada et al.   Cell Stem Cell

Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

(2013) Khaled Amara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

TGF-beta1 on osteoimmunology and the bone component cells

(2013) Shimpei Kasagi et al.   Cell and Bioscience

Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

(2012) Edward C Keystone et al.   ANNALS OF THE RHEUMATIC DISEASES

Myelopoiesis is regulated by osteocytes through Gs -dependent signaling

(2012) K. Fulzele et al.   BLOOD

Receptor Activator of Nuclear Factor κB Ligand (RANKL) Protein Expression by B Lymphocytes Contributes to Ovariectomy-induced Bone Loss

(2012) Melda Onal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The gut microbiota regulates bone mass in mice

(2012) Klara Sjögren et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Development and Function of Murine B Cells Lacking RANK

(2012) T. Perlot et al.   JOURNAL OF IMMUNOLOGY

Efficacy and Safety of CE-224,535, an Antagonist of P2X7 Receptor, in Treatment of Patients with Rheumatoid Arthritis Inadequately Controlled by Methotrexate

(2012) T. C. STOCK et al.   JOURNAL OF RHEUMATOLOGY

Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology

(2012) G. Hajishengallis et al.   Molecular Oral Microbiology

Antibiotics in early life alter the murine colonic microbiome and adiposity

(2012) Ilseung Cho et al.   NATURE

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

New developments in osteoimmunology

(2012) Hiroshi Takayanagi   Nature Reviews Rheumatology

Constitutively Activated NLRP3 Inflammasome Causes Inflammation and Abnormal Skeletal Development in Mice

(2012) Sheri L. Bonar et al.   PLoS One

Inflammation and Bone Destruction in Arthritis: Synergistic Activity of Immune and Mesenchymal Cells in Joints

(2012) Noriko Komatsu et al.   Frontiers in Immunology

Purinergic signalling in bone

(2012) Robin M. H. Rumney et al.   Frontiers in Endocrinology

Osteoclast activity modulates B-cell development in the bone marrow

(2011) Anna Mansour et al.   CELL RESEARCH

P2X7 receptor drives osteoclast fusion by increasing the extracellular adenosine concentration

(2011) Patrizia Pellegatti et al.   FASEB JOURNAL

Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection

(2011) Dallas Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization

(2011) Kana Miyamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human nutrition, the gut microbiome and the immune system

(2011) Andrew L. Kau et al.   NATURE

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

The microbiome and rheumatoid arthritis

(2011) Jose U. Scher et al.   Nature Reviews Rheumatology

Induction of Treg cells in the mouse colonic mucosa: A central mechanism to maintain host–microbiota homeostasis

(2011) Takeshi Tanoue et al.   SEMINARS IN IMMUNOLOGY

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells

(2010) Y. Nakamura et al.   BLOOD

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

(2010) Hsin-Jung Wu et al.   IMMUNITY

Creating and characterizing communities of human gut microbes in gnotobiotic mice

(2010) Jeremiah J Faith et al.   ISME Journal

P2X7 Receptor-Mediated Release of Cathepsins from Macrophages Is a Cytokine-Independent Mechanism Potentially Involved in Joint Diseases

(2010) G. Lopez-Castejon et al.   JOURNAL OF IMMUNOLOGY

The Role of Osteoclast-Associated Receptor in Osteoimmunology

(2010) K. Nemeth et al.   JOURNAL OF IMMUNOLOGY

The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro

(2010) Ankita Agrawal et al.   Purinergic Signalling

Understanding Estrogen Action during Menopause

(2009) Jameel Iqbal et al.   ENDOCRINOLOGY

Osteoimmunology and the effects of the immune system on bone

(2009) Hiroshi Takayanagi   Nature Reviews Rheumatology

Extracellular ATP in the Immune System: More Than Just a "Danger Signal"

(2009) A. Trautmann   Science Signaling

Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: Fibroblast-mediated pathologic bone resorption

(2008) Miklos Tunyogi-Csapo et al.   ARTHRITIS AND RHEUMATISM

Taking a Toll on the bones: Regulation of bone metabolism by innate immune regulators

(2008) Zvi Bar-Shavit   AUTOIMMUNITY

Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: A key mechanism in osteoporosis

(2008) Patrizia D'Amelio et al.   BONE

Human rheumatoid synoviocytes express functional P2X7 receptors

(2008) Francesca Caporali et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Osteoblastic regulation of B lymphopoiesis is mediated by Gs -dependent signaling pathways

(2008) J. Y. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA