Regulation of bone and cartilage by adenosine signaling

Disruption of biomineralization pathways in spinal tissues of a mouse model of diffuse idiopathic skeletal hyperostosis

(2016) Hisataka Ii et al.   BONE

Lack of effect of adenosine on the function of rodent osteoblasts and osteoclasts in vitro

(2016) Mark O. R. Hajjawi et al.   Purinergic Signalling

Lack of the nucleoside transporter ENT1 results in the Augustine-null blood type and ectopic mineralization

(2015) G. Daniels et al.   BLOOD

Direct or indirect stimulation of adenosine A2A receptors enhances bone regeneration as well as bone morphogenetic protein-2

(2015) Aránzazu Mediero et al.   FASEB JOURNAL

Brief Report: Methotrexate Prevents Wear Particle-Induced Inflammatory Osteolysis in Mice Via Activation of Adenosine A2AReceptor

(2015) Aránzazu Mediero et al.   Arthritis & Rheumatology

Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators

(2014) Maria Letizia Trincavelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mesenchymal Stem Cells From Different Murine Tissues Have Differential Capacity to Metabolize Extracellular Nucleotides

(2014) Isabele C. Iser et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Aberrant Bone Density in Aging Mice Lacking the Adenosine Transporter ENT1

(2014) David J. Hinton et al.   PLoS One

Rolofylline, an adenosine A1receptor antagonist, inhibits osteoclast differentiation as an inverse agonist

(2013) Wenjie He et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of adenosine A2Areceptor reduces osteoclast formation via PKA- and ERK1/2-mediated suppression of NFκB nuclear translocation

(2013) Aránzazu Mediero et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differentiation of mesenchymal stem cells to osteoblasts and chondrocytes: a focus on adenosine receptors

(2013) Shannon H. Carroll et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma

(2013) Wenjie He et al.   FASEB JOURNAL

Pulsed Electromagnetic Fields Increased the Anti-Inflammatory Effect of A2A and A3 Adenosine Receptors in Human T/C-28a2 Chondrocytes and hFOB 1.19 Osteoblasts

(2013) Fabrizio Vincenzi et al.   PLoS One

Adenosine A1 receptor stimulation enhances osteogenic differentiation of human dental pulp-derived mesenchymal stem cells via WNT signaling

(2013) Iolanda D'Alimonte et al.   Stem Cell Research

Adenosine and bone metabolism

(2013) Aránzazu Mediero et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes

(2013) Ann K Rosenthal et al.   ARTHRITIS RESEARCH & THERAPY

The stimulation of A3 adenosine receptors reduces bone-residing breast cancer in a rat preclinical model

(2012) Katia Varani et al.   EUROPEAN JOURNAL OF CANCER

Adenosine A2A receptor activation and hyaluronan fragment inhibition reduce inflammation in mouse articular chondrocytes stimulated with interleukin-1β

(2012) Giuseppe M. Campo et al.   FEBS Journal

Loss of equilibrative nucleoside transporter 1 in mice leads to progressive ectopic mineralization of spinal tissues resembling diffuse idiopathic skeletal hyperostosis in humans

(2012) Sumeeta Warraich et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice

(2012) Almut Grenz et al.   JOURNAL OF CLINICAL INVESTIGATION

Characteristic scapular and rib changes on chest radiographs of children with ADA-deficiency SCIDS in the first year of life

(2012) David Manson et al.   PEDIATRIC RADIOLOGY

ERK1 Regulates the Hematopoietic Stem Cell Niches

(2012) Nathalie Saulnier et al.   PLoS One

Vesicular and conductive mechanisms of nucleotide release

(2012) Eduardo R. Lazarowski   Purinergic Signalling

Adenosine A1 receptor regulates osteoclast formation by altering TRAF6/TAK1 signaling

(2012) W. He et al.   Purinergic Signalling

Adenosine A2A Receptor Activation Prevents Wear Particle-Induced Osteolysis

(2012) A. Mediero et al.   Science Translational Medicine

RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor

(2012) Christopher A. Nelson et al.   STRUCTURE

Differential effects of age on human striatal adenosine A1 and A2A receptors

(2012) Masahiro Mishina et al.   SYNAPSE

Adenosine A2A Receptor Ligation Inhibits Osteoclast Formation

(2011) Aránzazu Mediero et al.   AMERICAN JOURNAL OF PATHOLOGY

Polydeoxyribonucleotide reduces cytokine production and the severity of collagen-induced arthritis by stimulation of adenosine A2A receptor

(2011) Alessandra Bitto et al.   ARTHRITIS AND RHEUMATISM

The P2X7 receptor is an important regulator of extracellular ATP levels

(2011) A. Brandao-Burch et al.   BONE

Molecular Pathways: Osteoclast-Dependent and Osteoclast-Independent Roles of the RANKL/RANK/OPG Pathway in Tumorigenesis and Metastasis

(2011) W. C. Dougall   CLINICAL CANCER RESEARCH

P2X7 receptor drives osteoclast fusion by increasing the extracellular adenosine concentration

(2011) Patrizia Pellegatti et al.   FASEB JOURNAL

Contrasting effects of A1 and A2b adenosine receptors on adipogenesis

(2011) B Gharibi et al.   INTERNATIONAL JOURNAL OF OBESITY

Adenosine receptor subtype expression and activation influence the differentiation of mesenchymal stem cells to osteoblasts and adipocytes

(2011) Borzo Gharibi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

CD73-generated adenosine promotes osteoblast differentiation

(2011) Masahide Takedachi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

CGS 21680, an Agonist of the Adenosine (A2A) Receptor, Reduces Progression of Murine Type II Collagen-induced Arthritis

(2011) EMANUELA MAZZON et al.   JOURNAL OF RHEUMATOLOGY

Adenosine abolishes MTX-induced suppression of osteoclastogenesis and inflammatory bone destruction in adjuvant-induced arthritis

(2011) Junpei Teramachi et al.   LABORATORY INVESTIGATION

Absence of equilibrative nucleoside transporter 1 in ENT1 knockout mice leads to altered nucleoside levels following hypoxic challenge

(2011) Jennifer B. Rose et al.   LIFE SCIENCES

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Functional selectivity of adenosine receptor ligands

(2011) Dennis Verzijl et al.   Purinergic Signalling

Adenosine A1receptors regulate bone resorption in mice: Adenosine A1receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A1receptor-knockout mice

(2010) Firas M. Kara et al.   ARTHRITIS AND RHEUMATISM

Adenosine A1 receptors (A1Rs) play a critical role in osteoclast formation and function

(2010) Firas M. Kara et al.   FASEB JOURNAL

On the role of subtype selective adenosine receptor agonists during proliferation and osteogenic differentiation of human primary bone marrow stromal cells

(2010) M. Adelina Costa et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Complications With Recombinant Human Bone Morphogenic Protein-2 in Posterolateral Spine Fusion

(2010) Steven D. Glassman et al.   SPINE

ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency

(2009) A. V. Sauer et al.   BLOOD

Hypoxia stimulates vesicular ATP release from rat osteoblasts

(2009) Isabel R. Orriss et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

The Dynamic Control of Kiss-And-Run and Vesicular Reuse Probed with Single Nanoparticles

(2009) Q. Zhang et al.   SCIENCE

Bone as an endocrine organ

(2009) Seiji Fukumoto et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Wnt signaling acts and is regulated in a human osteoblast differentiation dependent manner

(2008) M. Eijken et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass

(2008) E. C. Hsiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma

(2008) Sang-Heon Kim et al.   RESPIRATORY MEDICINE

Polymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX

(2008) S. L. Hider et al.   RHEUMATOLOGY

Human equilibrative nucleoside transporter (ENT) family of nucleoside and nucleobase transporter proteins

(2008) J. D. Young et al.   XENOBIOTICA