The elusive case of human intraepithelial T cells in gut homeostasis and inflammation

ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation

(2017) Kamran Rostami et al.   GUT

Gut symbiotic microbes imprint intestinal immune cells with the innate receptor SLAMF4 which contributes to gut immune protection against enteric pathogens

(2017) Allison Cabinian et al.   GUT

Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency

(2017) Yannick Simoni et al.   IMMUNITY

The α4β1 Homing Pathway Is Essential for Ileal Homing of Crohnʼs Disease Effector T Cells In Vivo

(2017) Sebastian Zundler et al.   INFLAMMATORY BOWEL DISEASES

P617 Extraintestinal autoimmune phenomena during treatment with vedolizumab

(2017) D. Lissner et al.   Journal of Crohns & Colitis

P209 Long-term effectiveness and safety of vedolizumab in patients with ulcerative colitis: 5-year cumulative exposure of GEMINI 1 completers rolling into the GEMINI open-label extension study

(2017) E.V. Loftus et al.   Journal of Crohns & Colitis

T Cells in Celiac Disease

(2017) Bana Jabri et al.   JOURNAL OF IMMUNOLOGY

A committed postselection precursor to natural TCRαβ+ intraepithelial lymphocytes

(2017) Christoph S N Klose et al.   Mucosal Immunology

The composition of T cell subtypes in duodenal biopsies are altered in coeliac disease patients

(2017) Janni V. Steenholt et al.   PLoS One

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

(2016) Rafael Di Marco Barros et al.   CELL

Hallmarks of Tissue-Resident Lymphocytes

(2016) Xiying Fan et al.   CELL

Leukocyte Trafficking to the Small Intestine and Colon

(2016) Aida Habtezion et al.   GASTROENTEROLOGY

3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn’s Disease 2016: Part 1: Diagnosis and Medical Management

(2016) Fernando Gomollón et al.   Journal of Crohns & Colitis

Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β

(2016) Javed Mohammed et al.   NATURE IMMUNOLOGY

Impact of the gut microbiota on enhancer accessibility in gut intraepithelial lymphocytes

(2016) Nicholas P. Semenkovich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation

(2016) T. Sujino et al.   SCIENCE

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

(2015) Elizabeth M. Steinert et al.   CELL

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

(2015) Petter Brodin et al.   CELL

Aryl Hydrocarbon Receptor Activation Down-Regulates IL-7 and Reduces Inflammation in a Mouse Model of DSS-Induced Colitis

(2015) Tao Ji et al.   DIGESTIVE DISEASES AND SCIENCES

γδ Intraepithelial Lymphocyte Migration Limits Transepithelial Pathogen Invasion and Systemic Disease in Mice

(2015) Karen L. Edelblum et al.   GASTROENTEROLOGY

SLAMF4 Is a Negative Regulator of Expansion of Cytotoxic Intraepithelial CD8+ T Cells That Maintains Homeostasis in the Small Intestine

(2015) Michael S. O’Keeffe et al.   GASTROENTEROLOGY

Distinct and Synergistic Contributions of Epithelial Stress and Adaptive Immunity to Functions of Intraepithelial Killer Cells and Active Celiac Disease

(2015) Mala Setty et al.   GASTROENTEROLOGY

Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo

(2015) Anika Fischer et al.   GUT

T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate

(2015) Laura K. Mackay et al.   IMMUNITY

Keeping bugs in check: The mucus layer as a critical component in maintaining intestinal homeostasis

(2015) Martin Faderl et al.   IUBMB LIFE

Cysteinyl leukotrienes mediate lymphokine killer activity induced by NKG2D and IL-15 in cytotoxic T cells during celiac disease

(2015) Fangming Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues

(2015) Joseph J C Thome et al.   NATURE MEDICINE

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

The emerging role of resident memory T cells in protective immunity and inflammatory disease

(2015) Chang Ook Park et al.   NATURE MEDICINE

Resident memory T cells in human health and disease

(2015) R. A. Clark   Science Translational Medicine

Phenotypic analysis of T cells infiltrating colon cancers: Correlations with oncogenetic status

(2015) Mircea Chirica et al.   OncoImmunology

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

(2015) Troy D. Hubbard et al.   Scientific Reports

Altered faecal and mucosal microbial composition in post-infectious irritable bowel syndrome patients correlates with mucosal lymphocyte phenotypes and psychological distress

(2014) J. Sundin et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Generation of primary human intestinal T cell transcriptomes reveals differential expression at genetic risk loci for immune-mediated disease

(2014) Tim Raine et al.   GUT

Transcription Factor T-bet Regulates Intraepithelial Lymphocyte Functional Maturation

(2014) Bernardo S. Reis et al.   IMMUNITY

CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection

(2014) Brian J. Laidlaw et al.   IMMUNITY

A CD8+/CD103high T Cell Subset Regulates TNF-Mediated Chronic Murine Ileitis

(2014) J. Ho et al.   JOURNAL OF IMMUNOLOGY

Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial

(2014) Séverine Vermeire et al.   LANCET

Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells

(2014) G Bakdash et al.   Mucosal Immunology

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

Role and species-specific expression of colon T cell homing receptor GPR15 in colitis

(2014) Linh P Nguyen et al.   NATURE IMMUNOLOGY

Histopathology of Duodenal Mucosal Lesions in Pediatric Patients with Inflammatory Bowel Disease: Statistical Analysis to Identify Distinctive Features

(2014) Steven Hardee et al.   PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

Immunological Visibility: Posttranscriptional Regulation of Human NKG2D Ligands by the EGF Receptor Pathway

(2014) P. Vantourout et al.   Science Translational Medicine

CD4CD8αα Lymphocytes, A Novel Human Regulatory T Cell Subset Induced by Colonic Bacteria and Deficient in Patients with Inflammatory Bowel Disease

(2014) Guillaume Sarrabayrouse et al.   PLOS BIOLOGY

The Aryl Hydrocarbon Receptor Meets Immunology: Friend or Foe? A Little of Both

(2014) Walker Julliard et al.   Frontiers in Immunology

Characterization and Functional Properties of Gastric Tissue-Resident Memory T Cells from Children, Adults, and the Elderly

(2014) Jayaum S. Booth et al.   Frontiers in Immunology

Intraepithelial lymphocyte distribution differs between the bulb and the second part of duodenum

(2013) Olga Bednarska et al.   BMC GASTROENTEROLOGY

Tumor-infiltrating lymphocytes in colorectal tumors display a diversity of T cell receptor sequences that differ from the T cells in adjacent mucosal tissue

(2013) Anna M. Sherwood et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Colonic Mucosal Immune Activity in Irritable Bowel Syndrome: Comparison with Healthy Controls and Patients with Ulcerative Colitis

(2013) Ji Yong Ahn et al.   DIGESTIVE DISEASES AND SCIENCES

American Gastroenterological Association Institute Guideline on the Use of Thiopurines, Methotrexate, and Anti–TNF-α Biologic Drugs for the Induction and Maintenance of Remission in Inflammatory Crohn's Disease

(2013) Jonathan P. Terdiman et al.   GASTROENTEROLOGY

Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells

(2013) Anja Fuchs et al.   IMMUNITY

Transforming Growth Factor-β Signaling Controls the Formation and Maintenance of Gut-Resident Memory T Cells by Regulating Migration and Retention

(2013) Nu Zhang et al.   IMMUNITY

Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes

(2013) Wei Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of Intraepithelial Lymphocyte-Derived Cytokines on Intestinal Mucosal Barrier Function

(2013) Yuan Qiu et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

In vitro assessment of the effects of vedolizumab binding on peripheral blood lymphocytes

(2013) Tim Wyant et al.   mAbs

Regulatory T cells in nonlymphoid tissues

(2013) Dalia Burzyn et al.   NATURE IMMUNOLOGY

Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes

(2013) Daniel Mucida et al.   NATURE IMMUNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis

(2013) Brian G. Feagan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease

(2013) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Broad MICA/B Expression in the Small Bowel Mucosa: A Link between Cellular Stress and Celiac Disease

(2013) Yessica L. Allegretti et al.   PLoS One

Aryl hydrocarbon receptor and colitis

(2013) Ivan Monteleone et al.   Seminars in Immunopathology

Persistent Duodenal Intraepithelial Lymphocytosis Despite a Long-Term Strict Gluten-Free Diet in Celiac Disease

(2012) Ilus Tuire et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Celiac Disease: An Immunological Jigsaw

(2012) Bertrand Meresse et al.   IMMUNITY

Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets

(2012) Taheri Sathaliyawala et al.   IMMUNITY

Duodenal Intraepithelial Lymphocytosis With Normal Villous Architecture in Pediatric Patients

(2012) Eugenia Shmidt et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

IL-15 positively regulates IL-21 production in celiac disease mucosa

(2012) M Sarra et al.   Mucosal Immunology

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

Intraepithelial lymphocytes in celiac disease immunopathology

(2012) Valérie Abadie et al.   Seminars in Immunopathology

Celiac disease: Management of persistent symptoms in patients on a gluten-free diet

(2012) David H Dewar   WORLD JOURNAL OF GASTROENTEROLOGY

Changes of the cytokine profile in inflammatory bowel diseases

(2012) Györgyi Műzes   WORLD JOURNAL OF GASTROENTEROLOGY

Review article: remission rates achievable by current therapies for inflammatory bowel disease

(2011) L. Peyrin-Biroulet et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

(2011) Ying Li et al.   CELL

Role of mucus layers in gut infection and inflammation

(2011) Gunnar C Hansson   CURRENT OPINION IN MICROBIOLOGY

Aryl Hydrocarbon Receptor-Induced Signals Up-regulate IL-22 Production and Inhibit Inflammation in the Gastrointestinal Tract

(2011) Ivan Monteleone et al.   GASTROENTEROLOGY

Intestinal Inflammation and Cancer

(2011) Thomas A. Ullman et al.   GASTROENTEROLOGY

The increased expression of IL-23 in inflammatory bowel disease promotes intraepithelial and lamina propria lymphocyte inflammatory responses and cytotoxicity

(2011) Z. Liu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Intraepithelial T Cell Response to NKG2D-Ligands Links Lymphoid Stress Surveillance to Atopy

(2011) J. Strid et al.   SCIENCE

Expression of T cell receptors αβ and γδ in the ileal mucosa of patients with Crohn's disease and with spondylarthropathy

(2010) C. A. CUVELIER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Effect of α4β7 blockade on intestinal lymphocyte subsets and lymphoid tissue development

(2010) Caihong Wang et al.   INFLAMMATORY BOWEL DISEASES

Increased CD8+ intraepithelial lymphocyte infiltration and reduced surface area to volume ratio in the duodenum of patients with ulcerative colitis

(2010) Francesca Vidali et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Fetal and Adult Hematopoietic Stem Cells Give Rise to Distinct T Cell Lineages in Humans

(2010) J. E. Mold et al.   SCIENCE

Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia

(2009) M. M. WALKER et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Interleukin 21 up-regulates perforin-mediated cytotoxic activity of human intra-epithelial lymphocytes

(2009) Ellen C. Ebert   IMMUNOLOGY

Cytosolic PLA2is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15

(2009) Fangming Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reciprocal Interactions between Commensal Bacteria and    Intraepithelial Lymphocytes during Mucosal Injury

(2009) A. S. Ismail et al.   JOURNAL OF IMMUNOLOGY

Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes

(2009) S. Yokoyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal T cells: Facing the mucosal immune dilemma with synergy and diversity

(2009) Femke van Wijk et al.   SEMINARS IN IMMUNOLOGY

Meta-analysis: factors predicting post-operative recurrence with placebo therapy in patients with Crohn’s disease

(2008) M. PASCUA et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Doubting the TCR Coreceptor Function of CD8αα

(2008) Hilde Cheroutre et al.   IMMUNITY

Dissection of spontaneous cytotoxicity by human intestinal intraepithelial lymphocytes: MIC on colon cancer triggers NKG2D-mediated lysis through Fas ligand

(2008) Ellen C Ebert et al.   IMMUNOLOGY

Small intestinal CD8+TCRγδ+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease

(2008) Govind Bhagat et al.   JOURNAL OF CLINICAL INVESTIGATION

Epithelial restitution and wound healing in inflammatory bowel disease

(2008) Andreas Sturm et al.   WORLD JOURNAL OF GASTROENTEROLOGY