Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma

(2016) Ximena Bonilla et al.   NATURE GENETICS

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Effects of Combined Treatment With Arsenic Trioxide and Itraconazole in Patients With Refractory Metastatic Basal Cell Carcinoma

(2016) Mina S. Ally et al.   JAMA Dermatology

Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling Decreases Lung Fibrosis and Promotes Mesenchymal Cell Apoptosis

(2015) Thomas H. Sisson et al.   AMERICAN JOURNAL OF PATHOLOGY

Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma

(2015) Scott X. Atwood et al.   CANCER CELL

Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma

(2015) Hayley J. Sharpe et al.   CANCER CELL

RhoGTPases – A novel link between cytoskeleton organization and cisplatin resistance

(2015) Daphna Mokady et al.   DRUG RESISTANCE UPDATES

Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug-Resistant Basal Cell Carcinoma

(2015) Scott X. Atwood et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pivotal ERIVANCE basal cell carcinoma (BCC) study: 12-month update of efficacy and safety of vismodegib in advanced BCC

(2015) Aleksandar Sekulic et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Efficacy of Hedgehog Pathway Inhibitors in Basal Cell Carcinoma

(2015) N. Basset-Seguin et al.   MOLECULAR CANCER THERAPEUTICS

Squamous Change in Basal-Cell Carcinoma with Drug Resistance

(2015) Katherine J. Ransohoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1

(2015) Philipp Schneider et al.   Nature Communications

SRF Regulates Craniofacial Development through Selective Recruitment of MRTF Cofactors by PDGF Signaling

(2014) Harish N. Vasudevan et al.   DEVELOPMENTAL CELL

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts

(2014) C. Esnault et al.   GENES & DEVELOPMENT

Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition

(2014) D. E. Webster et al.   GENOME RESEARCH

Role of CRD-BP in the Growth of Human Basal Cell Carcinoma Cells

(2014) Felicite K. Noubissi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Advanced Treatment for Basal Cell Carcinomas

(2014) S. X. Atwood et al.   Cold Spring Harbor Perspectives in Medicine

Drug interactions with solid tumour-targeted therapies

(2013) Audrey Thomas-Schoemann et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

(2013) Laura A. Johnson et al.   INFLAMMATORY BOWEL DISEASES

GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas

(2013) Scott X. Atwood et al.   NATURE

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

The role of tumour–stromal interactions in modifying drug response: challenges and opportunities

(2013) Douglas W. McMillin et al.   NATURE REVIEWS DRUG DISCOVERY

Initial Assessment of Tumor Regrowth After Vismodegib in Advanced Basal Cell Carcinoma

(2012) Anne Lynn S. Chang et al.   ARCHIVES OF DERMATOLOGY

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis

(2012) Angelika Horn et al.   ARTHRITIS AND RHEUMATISM

Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy

(2012) Nicola Rath et al.   EMBO REPORTS

Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning

(2012) K. A. Peterson et al.   GENES & DEVELOPMENT

Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

(2012) Aleksandar Sekulic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Basal Cell Carcinomas Arise from Hair Follicle Stem Cells in Ptch1+/− Mice

(2011) Grace Ying Wang et al.   CANCER CELL

Establishment of Murine Basal Cell Carcinoma Allografts: A Potential Model for Preclinical Drug Testing and for Molecular Analysis

(2011) Grace Ying Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Rac and Rho GTPases in cancer cell motility control

(2010) Matteo Parri et al.   Cell Communication and Signaling

An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A

(2010) Rafał Pawłowski et al.   EMBO JOURNAL

Serum Response Factor Utilizes Distinct Promoter- and Enhancer-Based Mechanisms To Regulate Cytoskeletal Gene Expression in Macrophages

(2010) A. L. Sullivan et al.   MOLECULAR AND CELLULAR BIOLOGY

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

Linking actin dynamics and gene transcription to drive cellular motile functions

(2010) Eric N. Olson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis

(2010) E. Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PKA-Dependent Phosphorylation of Serum Response Factor Inhibits Smooth Muscle–Specific Gene Expression

(2009) Alicia L. Blaker et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cell biology of the movement of breast cancer cells: Intracellular signalling and the actin cytoskeleton

(2009) Ping Jiang et al.   CANCER LETTERS

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

(2008) S. A. Vokes et al.   GENES & DEVELOPMENT

Mitogen-induced recruitment of ERK and MSK to SRE promoter complexes by ternary complex factor Elk-1

(2008) Hong-Mei Zhang et al.   NUCLEIC ACIDS RESEARCH