From morphogen to morphogenesis and back

Synthetic biology meets tissue engineering

(2016) J. A. Davies et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Determining Physical Properties of the Cell Cortex

(2016) Arnab Saha et al.   BIOPHYSICAL JOURNAL

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Interface Contractility between Differently Fated Cells Drives Cell Elimination and Cyst Formation

(2016) Christina Bielmeier et al.   CURRENT BIOLOGY

A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization

(2016) Fred Etoc et al.   DEVELOPMENTAL CELL

Myosin-dependent remodeling of adherens junctions protects junctions from Snail-dependent disassembly

(2016) Mo Weng et al.   JOURNAL OF CELL BIOLOGY

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

(2016) Henner F. Farin et al.   NATURE

Asymmetric division of contractile domains couples cell positioning and fate specification

(2016) Jean-Léon Maître et al.   NATURE

Modular activation of Rho1 by GPCR signalling imparts polarized myosin II activation during morphogenesis

(2016) Stephen Kerridge et al.   NATURE CELL BIOLOGY

TissueMiner: A multiscale analysis toolkit to quantify how cellular processes create tissue dynamics

(2016) Raphaël Etournay et al.   eLife

Organoids and the genetically encoded self-assembly of embryonic stem cells

(2015) David A. Turner et al.   BIOESSAYS

Bending Gradients: How the Intestinal Stem Cell Gets Its Home

(2015) Amy E. Shyer et al.   CELL

Positional information and reaction-diffusion: two big ideas in developmental biology combine

(2015) J. B. A. Green et al.   DEVELOPMENT

Cell shape change and invagination of the cephalic furrow involves reorganization of F-actin

(2015) Allison K. Spencer et al.   DEVELOPMENTAL BIOLOGY

Sequential Contraction and Exchange of Apical Junctions Drives Zippering and Neural Tube Closure in a Simple Chordate

(2015) Hidehiko Hashimoto et al.   DEVELOPMENTAL CELL

Distinct Polarity Cues Direct Taz/Yap and TGFβ Receptor Localization to Differentially Control TGFβ-Induced Smad Signaling

(2015) Masahiro Narimatsu et al.   DEVELOPMENTAL CELL

Cell Density Sensing Alters TGF-β Signaling in a Cell-Type-Specific Manner, Independent from Hippo Pathway Activation

(2015) Flore Nallet-Staub et al.   DEVELOPMENTAL CELL

Cell shape and the microenvironment regulate nuclear translocation of NF- B in breast epithelial and tumor cells

(2015) J. E. Sero et al.   Molecular Systems Biology

Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour

(2015) Mathieu Frechin et al.   NATURE

A self-organized biomechanical network drives shape changes during tissue morphogenesis

(2015) Akankshi Munjal et al.   NATURE

Dpp spreading is required for medial but not for lateral wing disc growth

(2015) Stefan Harmansa et al.   NATURE

Local and tissue-scale forces drive oriented junction growth during tissue extension

(2015) Claudio Collinet et al.   NATURE CELL BIOLOGY

Myosin-II-mediated cell shape changes and cell intercalation contribute to primitive streak formation

(2015) Emil Rozbicki et al.   NATURE CELL BIOLOGY

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Mechanical strain induces E-cadherin-dependent Yap1 and  -catenin activation to drive cell cycle entry

(2015) B. W. Benham-Pyle et al.   SCIENCE

Embryo-scale tissue mechanics during Drosophila gastrulation movements

(2015) Matteo Rauzi et al.   Nature Communications

Mechanical Coupling between Endoderm Invagination and Axis Extension in Drosophila

(2015) Claire M. Lye et al.   PLOS BIOLOGY

Forms, forces, and stem cell fate

(2014) Evangelia Bellas et al.   CURRENT OPINION IN CELL BIOLOGY

p120-catenin-dependent junctional recruitment of Shroom3 is required for apical constriction during lens pit morphogenesis

(2014) R. A. Lang et al.   DEVELOPMENT

Scaling morphogen gradients during tissue growth by a cell division rule

(2014) I. Averbukh et al.   DEVELOPMENT

Apical constriction: themes and variations on a cellular mechanism driving morphogenesis

(2014) A. C. Martin et al.   DEVELOPMENT

The glucosyltransferase Xiantuan of the endoplasmic reticulum specifically affects E-Cadherin expression and is required for gastrulation movements in Drosophila

(2014) Yujun Zhang et al.   DEVELOPMENTAL BIOLOGY

Distinct Apical and Basolateral Mechanisms Drive Planar Cell Polarity-Dependent Convergent Extension of the Mouse Neural Plate

(2014) Margot Williams et al.   DEVELOPMENTAL CELL

Isotropic actomyosin dynamics promote organization of the apical cell cortex in epithelial cells

(2014) Christoph Klingner et al.   JOURNAL OF CELL BIOLOGY

Rho GTPase and Shroom direct planar polarized actomyosin contractility during convergent extension

(2014) Sérgio de Matos Simões et al.   JOURNAL OF CELL BIOLOGY

Dynamic myosin phosphorylation regulates contractile pulses and tissue integrity during epithelial morphogenesis

(2014) Claudia G. Vasquez et al.   JOURNAL OF CELL BIOLOGY

A positional Toll receptor code directs convergent extension in Drosophila

(2014) Adam C. Paré et al.   NATURE

Luminal signalling links cell communication to tissue architecture during organogenesis

(2014) Sevi Durdu et al.   NATURE

The ESCRT machinery regulates the secretion and long-range activity of Hedgehog

(2014) Tamás Matusek et al.   NATURE

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

PCP and Septins Compartmentalize Cortical Actomyosin to Direct Collective Cell Movement

(2014) A. Shindo et al.   SCIENCE

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

The minimal cadherin-catenin complex binds to actin filaments under force

(2014) C. D. Buckley et al.   SCIENCE

An In Vivo EGF Receptor Localization Screen in C. elegans Identifies the Ezrin Homolog ERM-1 as a Temporal Regulator of Signaling

(2014) Andrea Haag et al.   PLoS Genetics

Cytonemes and the dispersion of morphogens

(2014) Thomas B. Kornberg   Wiley Interdisciplinary Reviews-Developmental Biology

The interaction between Shroom3 and Rho-kinase is required for neural tube morphogenesis in mice

(2014) D. Das et al.   Biology Open

Forces in Tissue Morphogenesis and Patterning

(2013) Carl-Philipp Heisenberg et al.   CELL

Apical constriction initiates new bud formation during monopodial branching of the embryonic chicken lung

(2013) H. Y. Kim et al.   DEVELOPMENT

Gprk2 adjusts Fog signaling to organize cell movements in Drosophila gastrulation

(2013) N. Fuse et al.   DEVELOPMENT

Distinct Rap1 Activity States Control the Extent of Epithelial Invagination via α-Catenin

(2013) Yu-Chiun Wang et al.   DEVELOPMENTAL CELL

Patterning and growth control by membrane-tethered Wingless

(2013) Cyrille Alexandre et al.   NATURE

Apical domain polarization localizes actin–myosin activity to drive ratchet-like apical constriction

(2013) Frank M. Mason et al.   NATURE CELL BIOLOGY

A Vertex Model of Drosophila Ventral Furrow Formation

(2013) Philipp Spahn et al.   PLoS One

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

(2013) M. A. Nieto   SCIENCE

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Regulation of Epithelial Morphogenesis by the G Protein-Coupled Receptor Mist and Its Ligand Fog

(2013) A. J. Manning et al.   Science Signaling

Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria

(2013) Thibaut Brunet et al.   Nature Communications

Planar Cell Polarity Links Axes of Spatial Dynamics in Neural-Tube Closure

(2012) Tamako Nishimura et al.   CELL

Fgfr-Ras-MAPK signaling is required for apical constriction via apical positioning of Rho-associated kinase during mechanosensory organ formation

(2012) M. J. Harding et al.   DEVELOPMENT

Shroom3 is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish

(2012) S. Ernst et al.   DEVELOPMENT

Convergent extension: using collective cell migration and cell intercalation to shape embryos

(2012) M. Tada et al.   DEVELOPMENT

Abl Regulates Planar Polarized Junctional Dynamics through β-Catenin Tyrosine Phosphorylation

(2012) Masako Tamada et al.   DEVELOPMENTAL CELL

The PDZ-GEF protein Dizzy regulates the establishment of adherens junctions required for ventral furrow formation in Drosophila

(2012) P. Spahn et al.   JOURNAL OF CELL SCIENCE

Heterotrimeric G protein signaling governs the cortical stability during apical constriction in Drosophila gastrulation

(2012) Takuma Kanesaki et al.   MECHANISMS OF DEVELOPMENT

Differential positioning of adherens junctions is associated with initiation of epithelial folding

(2012) Yu-Chiun Wang et al.   NATURE

Regulation of epithelial polarity by the E3 ubiquitin ligase Neuralized and the Bearded inhibitors in Drosophila

(2012) Soline Chanet et al.   NATURE CELL BIOLOGY

Classifying collective cancer cell invasion

(2012) Peter Friedl et al.   NATURE CELL BIOLOGY

Vertebrate kidney tubules elongate using a planar cell polarity–dependent, rosette-based mechanism of convergent extension

(2012) Soeren S Lienkamp et al.   NATURE GENETICS

Computational Approaches to Developmental Patterning

(2012) L. G. Morelli et al.   SCIENCE

Physical Biology Returns to Morphogenesis

(2012) R. Keller   SCIENCE

Relaxation-expansion model for self-driven retinal morphogenesis

(2011) Mototsugu Eiraku et al.   BIOESSAYS

A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination

(2011) T. F. Plageman et al.   DEVELOPMENT

Role for Traf4 in Polarizing Adherens Junctions as a Prerequisite for Efficient Cell Shape Changes

(2011) S. J. Mathew et al.   MOLECULAR AND CELLULAR BIOLOGY

A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension

(2011) Jessica K. Sawyer et al.   MOLECULAR BIOLOGY OF THE CELL

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis

(2011) Romain Levayer et al.   NATURE CELL BIOLOGY

Origins of regulated cell-to-cell variability

(2011) Berend Snijder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of a Pentavalent G-Actin*MRTF-A Complex Reveals How G-Actin Controls Nucleocytoplasmic Shuttling of a Transcriptional Coactivator

(2011) S. Mouilleron et al.   Science Signaling

Local BMP receptor activation at adherens junctions in the Drosophila germline stem cell niche

(2011) Marcus Michel et al.   Nature Communications

Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium of Drosophila

(2010) Benoît Aigouy et al.   CELL

Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination

(2010) T. F. Plageman et al.   DEVELOPMENT

Direct activation of Shroom3 transcription by Pitx proteins drives epithelial morphogenesis in the developing gut

(2010) M.-I Chung et al.   DEVELOPMENT

Rho-Kinase Directs Bazooka/Par-3 Planar Polarity during Drosophila Axis Elongation

(2010) Sérgio de Matos Simões et al.   DEVELOPMENTAL CELL

Integration of contractile forces during tissue invagination

(2010) Adam C. Martin et al.   JOURNAL OF CELL BIOLOGY

Epithelial cell shape is regulated by Lulu proteins via myosin-II

(2010) H. Nakajima et al.   JOURNAL OF CELL SCIENCE

Pulsed Forces Timed by a Ratchet-like Mechanism Drive Directed Tissue Movement during Dorsal Closure

(2009) Jerome Solon et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

EMT 2.0: shaping epithelia through collective migration

(2009) Céline Revenu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Myosin II Dynamics Are Regulated by Tension in Intercalating Cells

(2009) Rodrigo Fernandez-Gonzalez et al.   DEVELOPMENTAL CELL

The shroom family proteins play broad roles in the morphogenesis of thickened epithelial sheets

(2009) Chanjae Lee et al.   DEVELOPMENTAL DYNAMICS

TheDrosophilaafadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction

(2009) Jessica K. Sawyer et al.   JOURNAL OF CELL BIOLOGY

Cell shape changes indicate a role for extrinsic tensile forces in Drosophila germ-band extension

(2009) Lucy C. Butler et al.   NATURE CELL BIOLOGY

Collective cell migration in morphogenesis, regeneration and cancer

(2009) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesis

(2008) C. C. F. Homem et al.   DEVELOPMENT

Dynamic Fgf signaling couples morphogenesis and migration in the zebrafish lateral line primordium

(2008) V. Lecaudey et al.   DEVELOPMENT

Shroom3-mediated recruitment of Rho kinases to the apical cell junctions regulates epithelial and neuroepithelial planar remodeling

(2008) T. Nishimura et al.   DEVELOPMENT

Tissue Deformation Modulates Twist Expression to Determine Anterior Midgut Differentiation in Drosophila Embryos

(2008) Nicolas Desprat et al.   DEVELOPMENTAL CELL

Pulsed contractions of an actin–myosin network drive apical constriction

(2008) Adam C. Martin et al.   NATURE

Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis

(2008) Matteo Rauzi et al.   NATURE CELL BIOLOGY

FGF-Dependent Mechanosensory Organ Patterning in Zebrafish

(2008) A. Nechiporuk et al.   SCIENCE

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(2008) Jeffrey Settleman et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Multicellular dynamics during epithelial elongation

(2008) Jennifer A. Zallen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY