I-motif DNA structures are formed in the nuclei of human cells

Prevalent Sequences in the Human Genome Can Form Mini i-Motif Structures at Physiological pH

(2017) Bartomeu Mir et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

4n–1 Is a “Sweet Spot” in DNA i-Motif Folding of 2′-Deoxycytidine Homopolymers

(2017) Aaron M. Fleming et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Targeting of Both Structures by Small Molecules To Downregulate Gene Expression

(2017) Robert V. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression

(2017) Christine E. Kaiser et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of multiple genomic DNA sequences which form i-motif structures at neutral pH

(2017) Elisé P. Wright et al.   NUCLEIC ACIDS RESEARCH

Topological impact of noncanonical DNA structures on Klenow fragment of DNA polymerase

(2017) Shuntaro Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-associated noncoding mutations affect RNA G-quadruplex-mediated regulation of gene expression

(2017) Mahdi Zeraati et al.   Scientific Reports

Mutually Exclusive Formation of G-Quadruplex and i-Motif Is a General Phenomenon Governed by Steric Hindrance in Duplex DNA

(2016) Yunxi Cui et al.   BIOCHEMISTRY

Thermodynamic linkage analysis of pH-induced folding and unfolding transitions of i-motifs

(2016) Byul G. Kim et al.   BIOPHYSICAL CHEMISTRY

The formation and characteristics of the i-motif structure within the promoter of the c-myb proto-oncogene

(2016) Huihui Li et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Interaction of Individual Structural Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA

(2016) Basab Roy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Mechanosensor Mechanism Controls the G-Quadruplex/i-Motif Molecular Switch in the MYC Promoter NHE III1

(2016) Caleb Sutherland et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Understanding the effect of the nature of the nucleobase in the loops on the stability of the i-motif structure

(2016) Sanae Benabou et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

The importance of loop length on the stability of i-motif structures

(2015) Sarah P. Gurung et al.   CHEMICAL COMMUNICATIONS

Centromeric Alpha-Satellite DNA Adopts Dimeric i-Motif Structures Capped by AT Hoogsteen Base Pairs

(2015) Miguel Garavís et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fully Human VHSingle Domains That Rival the Stability and Cleft Recognition of Camelid Antibodies

(2015) Romain Rouet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Regulation of telomeric i-motif stability by 5-methylcytosine and 5-hydroxymethylcytosine modification

(2015) Baochang Xu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Loop nucleotides impact the stability of intrastrand i-motif structures at neutral pH

(2015) Taiga Fujii et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

i-Motif DNA: Structure, stability and targeting with ligands

(2014) Henry A. Day et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure

(2014) Samantha Kendrick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Transcriptional Complex Between the BCL2 i-Motif and hnRNP LL Is a Molecular Switch for Control of Gene Expression That Can Be Modulated by Small Molecules

(2014) Hyun-Jin Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fundamental aspects of the nucleic acid i-motif structures

(2014) S. Benabou et al.   RSC Advances

I-Motif-Programmed Functionalization of DNA Nanocircles

(2013) Tao Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA quadruplex folding formalism – A tutorial on quadruplex topologies

(2013) Andreas Ioannis Karsisiotis et al.   METHODS

The Effect of Molecular Crowding on the Stability of Human c-MYC Promoter Sequence I-Motif at Neutral pH

(2013) Jingjing Cui et al.   MOLECULES

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes

(2013) Prashansa Agrawal et al.   NUCLEIC ACIDS RESEARCH

The G4 Genome

(2013) Nancy Maizels et al.   PLoS Genetics

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

Intramolecular Folding in Human ILPR Fragment with Three C-Rich Repeats

(2012) Soma Dhakal et al.   PLoS One

General strategy for the generation of human antibody variable domains with increased aggregation resistance

(2012) K. Dudgeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular crowding of the cosolutes induces an intramolecular i-motif structure of triplet repeat DNA oligomers at neutral pH

(2010) Arivazhagan Rajendran et al.   CHEMICAL COMMUNICATIONS

Making sense of G-quadruplex and i-motif functions in oncogene promoters

(2010) Tracy A. Brooks et al.   FEBS Journal

Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter

(2010) Vitaly Kuryavyi et al.   NUCLEIC ACIDS RESEARCH

The Importance of Negative Superhelicity in Inducing the Formation of G-Quadruplex and i-Motif Structures in the c-Myc Promoter: Implications for Drug Targeting and Control of Gene Expression

(2009) Daekyu Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

pH-Dependent Structures of an i-Motif DNA in Solution

(2009) Kyeong Sik Jin et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The i-Motif in thebcl-2P1 Promoter Forms an Unexpectedly Stable Structure with a Unique 8:5:7 Loop Folding Pattern

(2009) Samantha Kendrick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene

(2008) K. Guo et al.   NUCLEIC ACIDS RESEARCH