A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families

(2017) Oksana Voloshanenko et al.   FASEB JOURNAL

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

(2017) Felipe de Sousa e Melo et al.   NATURE

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

(2017) Claudia Y. Janda et al.   NATURE

Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding

(2017) Aaron H. Nile et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Fatty acylation of Wnt proteins

(2016) Aaron H Nile et al.   Nature Chemical Biology

Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

(2016) Zachary Steinhart et al.   NATURE MEDICINE

Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses

(2016) Karpagam Srinivasan et al.   Nature Communications

Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5 + Intestinal Stem Cells

(2016) Tae-Hee Kim et al.   Cell Reports

Frizzled7: A Promising Achilles’ Heel for Targeting the Wnt Receptor Complex to Treat Cancer

(2016) Toby Phesse et al.   Cancers

FRIZZLED7 Is Required for Tumor Inititation and Metastatic Growth of Melanoma Cells

(2016) Shweta Tiwary et al.   PLoS One

Structural basis of the Norrin-Frizzled 4 interaction

(2015) Guobo Shen et al.   CELL RESEARCH

Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled

(2015) Ho-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic Mapping of WNT-FZD Protein Interactions Reveals Functional Selectivity by Distinct WNT-FZD Pairs

(2015) Jacomijn P. Dijksterhuis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined automated NOE assignment and structure calculation with CYANA

(2015) Peter Güntert et al.   JOURNAL OF BIOMOLECULAR NMR

Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases

(2015) Xiaomo Jiang et al.   MOLECULAR CELL

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Porcupine inhibitor suppresses paracrine Wnt-driven growth ofRnf43;Znrf3-mutant neoplasia

(2015) Bon-Kyoung Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposing Activities of Notch and Wnt Signaling Regulate Intestinal Stem Cells and Gut Homeostasis

(2015) Hua Tian et al.   Cell Reports

Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells

(2015) Dustin J. Flanagan et al.   Stem Cell Reports

WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors

(2014) Jamie N. Anastas et al.   JOURNAL OF CLINICAL INVESTIGATION

RNF43 is frequently mutated in colorectal and endometrial cancers

(2014) Marios Giannakis et al.   NATURE GENETICS

The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells

(2014) A. Fernandez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy

(2014) T Grabinger et al.   Cell Death & Disease

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Quantitative set analysis for gene expression: a method to quantify gene set differential expression including gene-gene correlations

(2013) Gur Yaari et al.   NUCLEIC ACIDS RESEARCH

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

(2013) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities

(2012) Rani Najdi et al.   DIFFERENTIATION

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization

(2012) Karen Stanger et al.   Nature Chemical Biology

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

(2012) A. Gurney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Wnt Signaling in Cancer

(2012) P. Polakis   Cold Spring Harbor Perspectives in Biology

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Fast and SNP-tolerant detection of complex variants and splicing in short reads

(2010) T. D. Wu et al.   BIOINFORMATICS

Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6

(2010) Eric Bourhis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Inhibition of Wnt signaling by Dishevelled PDZ peptides

(2009) Yingnan Zhang et al.   Nature Chemical Biology

The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression

(2008) Elizabeth Vincan et al.   CLINICAL & EXPERIMENTAL METASTASIS

Kinetics of Wnt-Driven β-Catenin Stabilization Revealed by Quantitative and Temporal Imaging

(2008) Rami N. Hannoush   PLoS One