Buried treasure: biosynthesis, structures and applications of cyclic peptides hidden in seed storage albumins

Two proteins for the price of one: Structural studies of the dual-destiny protein preproalbumin with sunflower trypsin inhibitor-1

(2017) Bastian Franke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease

(2017) Claudia Cobos Caceres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design of Potent and Selective Cathepsin G Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold

(2017) Joakim E. Swedberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stepwise Evolution of a Buried Inhibitor Peptide over 45 My

(2017) Achala S. Jayasena et al.   MOLECULAR BIOLOGY AND EVOLUTION

Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products

(2017) Niels S van der Velden et al.   Nature Chemical Biology

Evidence for Ancient Origins of Bowman-Birk Inhibitors from Selaginella moellendorffii

(2017) Amy M. James et al.   PLANT CELL

Traceless Production of Cyclic Peptide Libraries in E. coli

(2016) Jaime E. Townend et al.   ACS Chemical Biology

Natural structural diversity within a conserved cyclic peptide scaffold

(2016) Alysha G. Elliott et al.   AMINO ACIDS

Efficient recombinant expression of SFTI-1 in bacterial cells using intein-mediated protein trans-splicing

(2016) Yilong Li et al.   BIOPOLYMERS

Noncovalent inhibitors of human 20S and 26S proteasome based on trypsin inhibitor SFTI-1

(2016) Dawid Dębowski et al.   BIOPOLYMERS

Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana )

(2016) Bastian Franke et al.   BIOPOLYMERS

Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold

(2016) Conan K. Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics

(2016) Blake T. Riley et al.   Scientific Reports

In VivoEfficacy of Anuran Trypsin Inhibitory Peptides against Staphylococcal Skin Infection and the Impact of Peptide Cyclization

(2015) U. Malik et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition

(2015) Simon J. de Veer et al.   BIOCHEMICAL JOURNAL

Cyclic thrombospondin-1 mimetics: grafting of a thrombospondin sequence into circular disulfide-rich frameworks to inhibit endothelial cell migration

(2015) L. Y. Chan et al.   BIOSCIENCE REPORTS

Inhibitors of Matriptase-2 Based on the Trypsin Inhibitor SFTI-1

(2015) Agata Gitlin et al.   CHEMBIOCHEM

Peptide Macrocyclization by a Bifunctional Endoprotease

(2015) Kalia Bernath-Levin et al.   CHEMISTRY & BIOLOGY

Improving the Selectivity of Engineered Protease Inhibitors: Optimizing the P2 Prime Residue Using a Versatile Cyclic Peptide Library

(2015) Simon J. de Veer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

(2015) Karen S. Harris et al.   Nature Communications

An Efficient Method for the In Vitro Production of Azol(in)e-Based Cyclic Peptides

(2014) Wael E. Houssen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Peptide Macrocyclization Catalyzed by a Prolyl Oligopeptidase Involved in α-Amanitin Biosynthesis

(2014) Hong Luo et al.   CHEMISTRY & BIOLOGY

Seed storage albumins: biosynthesis, trafficking and structures

(2014) Joshua S. Mylne et al.   FUNCTIONAL PLANT BIOLOGY

Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis

(2014) Giang K T Nguyen et al.   Nature Chemical Biology

Evolutionary Origins of a Bioactive Peptide Buried within Preproalbumin

(2014) Alysha G. Elliott et al.   PLANT CELL

Next generation sequencing and de novo transcriptomics to study gene evolution

(2014) Achala S Jayasena et al.   Plant Methods

The Two-step Biosynthesis of Cyclic Peptides from Linear Precursors in a Member of the Plant Family Caryophyllaceae Involves Cyclization by a Serine Protease-like Enzyme

(2013) Carla J. S. Barber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-affinity Cyclic Peptide Matriptase Inhibitors

(2013) Pedro Quimbar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic Potential of the Peptide Leucine Arginine As a New Nonplant Bowman–Birk-Like Serine Protease Inhibitor

(2013) Sven Rothemund et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combinatorial tuning of peptidic drug candidates: high-affinity matriptase inhibitors through incremental structure-guided optimization

(2013) Heiko Fittler et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cyclic Peptides Arising by Evolutionary Parallelism via Asparaginyl-Endopeptidase-Mediated Biosynthesis

(2012) J. S. Mylne et al.   PLANT CELL

Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds

(2011) L. Y. Chan et al.   BLOOD

Ribosomal synthesis of backbone macrocyclic peptides

(2011) Takayuki Katoh et al.   CHEMICAL COMMUNICATIONS

Identification and Characterization of a New Family of Cell-penetrating Peptides

(2011) Laura Cascales et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Albumins and their processing machinery are hijacked for cyclic peptides in sunflower

(2011) Joshua S Mylne et al.   Nature Chemical Biology

Contemporary strategies for peptide macrocyclization

(2011) Christopher J. White et al.   Nature Chemistry

Distinct Roles of Protein Disulfide Isomerase and P5 Sulfhydryl Oxidoreductases in Multiple Pathways for Oxidation of Structurally Diverse Storage Proteins in Rice

(2011) Yayoi Onda et al.   PLANT CELL

Mastering the Canonical Loop of Serine Protease Inhibitors: Enhancing Potency by Optimising the Internal Hydrogen Bond Network

(2011) Joakim E. Swedberg et al.   PLoS One

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

(2010) Richard J. Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Naturally occurring circular proteins: distribution, biosynthesis and evolution

(2010) Laura Cascales et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

In vivo biosynthesis of an Ala-scan library based on the cyclic peptide SFTI-1

(2009) Jeffrey Austin et al.   AMINO ACIDS

Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors

(2009) Anna Łęgowska et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Substrate-Guided Design of a Potent and Selective Kallikrein-Related Peptidase Inhibitor for Kallikrein 4

(2009) Joakim E. Swedberg et al.   CHEMISTRY & BIOLOGY