Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis

Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis

(2017) U. R. Awodi et al.   Chemical Science

Deciphering Piperidine Formation in Polyketide-Derived Indolizidines Reveals a Thioester Reduction, Transamination, and Unusual Imine Reduction Process

(2016) Haidong Peng et al.   ACS Chemical Biology

Structural insight into the necessary conformational changes of modular nonribosomal peptide synthetases

(2016) Andrew M Gulick   CURRENT OPINION IN CHEMICAL BIOLOGY

Structures of two distinct conformations of holo-non-ribosomal peptide synthetases

(2016) Eric J. Drake et al.   NATURE

Synthetic cycle of the initiation module of a formylating nonribosomal peptide synthetase

(2016) Janice M. Reimer et al.   NATURE

FoXS, FoXSDock and MultiFoXS: Single-state and multi-state structural modeling of proteins and their complexes based on SAXS profiles

(2016) Dina Schneidman-Duhovny et al.   NUCLEIC ACIDS RESEARCH

Structural elements of an NRPS cyclization domain and its intermodule docking domain

(2016) Daniel P. Dowling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EngineeringYarrowia lipolyticaas a platform for synthesis of drop-in transportation fuels and oleochemicals

(2016) Peng Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Production of fatty acid-derived oleochemicals and biofuels by synthetic yeast cell factories

(2016) Yongjin J. Zhou et al.   Nature Communications

One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts

(2016) Scott P. France et al.   ACS Catalysis

Synthesis of α,β-unsaturated esters via a chemo-enzymatic chain elongation approach by combining carboxylic acid reduction and Wittig reaction

(2015) Yitao Duan et al.   Beilstein Journal of Organic Chemistry

Kinetically and Crystallographically Guided Mutations of a Benzoate CoA Ligase (BadA) Elucidate Mechanism and Expand Substrate Permissivity

(2015) Chelsea K. Thornburg et al.   BIOCHEMISTRY

Portability of the thiolation domain in recombinant pyoverdine non-ribosomal peptide synthetases

(2015) Mark J. Calcott et al.   BMC MICROBIOLOGY

Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols

(2015) Jesus F. Barajas et al.   CHEMISTRY & BIOLOGY

Dynamics-Driven Allostery in Protein Kinases

(2015) Alexandr P. Kornev et al.   TRENDS IN BIOCHEMICAL SCIENCES

Advanced ensemble modelling of flexible macromolecules using X-ray solution scattering

(2015) Giancarlo Tria et al.   IUCrJ

Assembly Line Polyketide Synthases: Mechanistic Insights and Unsolved Problems

(2014) Chaitan Khosla et al.   BIOCHEMISTRY

An engineered pathway for the biosynthesis of renewable propane

(2014) Pauli Kallio et al.   Nature Communications

ThePDB_REDOserver for macromolecular structure model optimization

(2014) Robbie P. Joosten et al.   IUCrJ

Decision making inxia2

(2013) Graeme Winter et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Microbial production of fatty acid-derived fuels and chemicals

(2013) Rebecca M Lennen et al.   CURRENT OPINION IN BIOTECHNOLOGY

PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis

(2013) Marie-France Langelier et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Accurate assessment of mass, models and resolution by small-angle scattering

(2013) Robert P. Rambo et al.   NATURE

Diversity of Allosteric Regulation in Proteases

(2012) Melisa Merdanovic et al.   ACS Chemical Biology

New developments in theATSASprogram package for small-angle scattering data analysis

(2012) Maxim V. Petoukhov et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology

(2012) Gene H. Hur et al.   NATURAL PRODUCT REPORTS

Nonprocessive [2 + 2]e- off-loading reductase domains from mycobacterial nonribosomal peptide synthetases

(2012) A. Chhabra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities

(2012) M. K. Akhtar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Experimental phasing withSHELXC/D/E: combining chain tracing with density modification

(2010) George M. Sheldrick   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Nonribosomal peptide synthetases: structures and dynamics

(2010) Matthias Strieker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

FoXS: a web server for rapid computation and fitting of SAXS profiles

(2010) D. Schneidman-Duhovny et al.   NUCLEIC ACIDS RESEARCH

Conformational Dynamics in the Acyl-CoA Synthetases, Adenylation Domains of Non-ribosomal Peptide Synthetases, and Firefly Luciferase

(2009) Andrew M. Gulick   ACS Chemical Biology

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural Snapshots for the Conformation-dependent Catalysis by Human Medium-chain Acyl-coenzyme A Synthetase ACSM2A

(2009) Grazyna Kochan et al.   JOURNAL OF MOLECULAR BIOLOGY

Medium- and short-chain dehydrogenase/reductase gene and protein families

(2008) K. L. Kavanagh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Are Environmentally Coupled Enzymatic Hydrogen Tunneling Reactions Influenced by Changes in Solution Viscosity?

(2007) Sam Hay et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION