Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics

Flavoenzyme-Catalyzed Formation of Disulfide Bonds in Natural Products

(2014) Daniel H. Scharf et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of Pyrroloformamide as a Cytokinesis Modulator

(2014) Paula A. Abreu et al.   CHEMBIOCHEM

The Fish PathogenYersinia ruckeriProduces Holomycin and Uses an RNA Methyltransferase for Self-resistance

(2013) Zhiwei Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Hybrid-Type Antimicrobial Agents Targeting the Switch Region of Bacterial RNA Polymerase

(2013) Fumika Yakushiji et al.   ACS Medicinal Chemistry Letters

Engineered Streptomyces avermitilis Host for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites

(2013) Mamoru Komatsu et al.   ACS Synthetic Biology

Induction of Holomycin Production and Complex Metabolic Changes by theargRMutation in Streptomyces clavuligerus NP1

(2012) Hua Yin et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A Backup Plan for Self-Protection: S-Methylation of Holomycin Biosynthetic Intermediates inStreptomyces clavuligerus

(2012) Bo Li et al.   CHEMBIOCHEM

Synthesis of Substituted 6-Amino-4-(2,4-dimethoxyphenyl)-[1,2]dithiolo[4,3-b]pyrrol-5-ones and Their Raising Leukocyte Count Activities

(2012) Xiangduan Tan et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Transcriptional analysis and proteomics of the holomycin gene cluster in overproducer mutants of Streptomyces clavuligerus

(2012) V. Robles-Reglero et al.   JOURNAL OF BIOTECHNOLOGY

Engineered Thiomarinol Antibiotics Active against MRSA Are Generated by Mutagenesis and Mutasynthesis of Pseudoalteromonas SANK73390

(2011) Annabel C. Murphy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Streptomyces clavuligerusHlmI Is an Intramolecular Disulfide-Forming Dithiol Oxidase in Holomycin Biosynthesis

(2011) Bo Li et al.   BIOCHEMISTRY

New dithiolopyrrolone antibiotics induced by adding sorbic acid to the culture medium of Saccharothrix algeriensis NRRL B-24137

(2011) Rabiâa Merrouche et al.   FEMS MICROBIOLOGY LETTERS

Identification of Cryptic Products of the Gliotoxin Gene Cluster Using NMR-Based Comparative Metabolomics and a Model for Gliotoxin Biosynthesis

(2011) Ry R. Forseth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Natural Plasmid Uniquely Encodes Two Biosynthetic Pathways Creating a Potent Anti-MRSA Antibiotic

(2011) Daisuke Fukuda et al.   PLoS One

Clavulanic acid biosynthesis and genetic manipulation for its overproduction

(2010) Ju Yeon Song et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Sequence of a 1.8-Mb Bacterial Linear Plasmid Reveals a Rich Evolutionary Reservoir of Secondary Metabolic Pathways

(2010) Marnix H. Medema et al.   Genome Biology and Evolution

Draft Genome Sequence of Streptomyces clavuligerus NRRL 3585, a Producer of Diverse Secondary Metabolites

(2010) J. Y. Song et al.   JOURNAL OF BACTERIOLOGY

Transannular Disulfide Formation in Gliotoxin Biosynthesis and Its Role in Self-Resistance of the Human PathogenAspergillus fumigatus

(2010) Daniel H. Scharf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibacterial Compounds from Marine Vibrionaceae Isolated on a Global Expedition

(2010) Matthias Wietz et al.   Marine Drugs

Resistance to and synthesis of the antibiotic mupirocin

(2010) Christopher M. Thomas et al.   NATURE REVIEWS MICROBIOLOGY

Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus

(2010) B. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus

(2010) Sheng Huang et al.   PROCESS BIOCHEMISTRY

Self-Protection against Gliotoxin—A Component of the Gliotoxin Biosynthetic Cluster, GliT, Completely Protects Aspergillus fumigatus Against Exogenous Gliotoxin

(2010) Markus Schrettl et al.   PLoS Pathogens

A rhodanese-like protein is highly overrepresented in the mutant S. clavuligerus oppA2::aph: effect on holomycin and other secondary metabolites production

(2010) Nuria Nárdiz et al.   Microbial Biotechnology

Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton

(2009) Yifeng Jia et al.   CELL STRESS & CHAPERONES

An FAD-Dependent Pyridine Nucleotide-Disulfide Oxidoreductase Is Involved in Disulfide Bond Formation in FK228 Anticancer Depsipeptide

(2009) Cheng Wang et al.   CHEMISTRY & BIOLOGY

Crystal Structures of an Oligopeptide-Binding Protein from the Biosynthetic Pathway of the β-Lactamase Inhibitor Clavulanic Acid

(2009) Alasdair K. Mackenzie et al.   JOURNAL OF MOLECULAR BIOLOGY

Comprehensive Characterization of Heat Shock Protein 27 Phosphorylation in Human Endothelial Cells Stimulated by the Microbial Dithiole Thiolutin

(2008) Shujia Dai et al.   JOURNAL OF PROTEOME RESEARCH

Precursor-directed biosynthesis of new dithiolopyrrolone analogs by Saccharothrix algeriensis NRRL B-24137

(2008) Noureddine Bouras et al.   PROCESS BIOCHEMISTRY

The transcriptional inhibitor thiolutin blocks mRNA degradation in yeast

(2007) Vicent Pelechano et al.   YEAST