Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases

Discovery of an Inhibitor of the Proteasome Subunit Rpn11

(2017) Christian Perez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11

(2017) Jing Li et al.   Nature Chemical Biology

p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency

(2015) J. I. Belle et al.   BLOOD

Higher-Order Assembly of BRCC36–KIAA0157 Is Required for DUB Activity and Biological Function

(2015) Elton Zeqiraj et al.   MOLECULAR CELL

Deubiquitinase inhibition as a cancer therapeutic strategy

(2015) Padraig D'Arcy et al.   PHARMACOLOGY & THERAPEUTICS

Transcriptional refractoriness is dependent on core promoter architecture

(2015) François Cesbron et al.   Nature Communications

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

(2014) Raymond J Deshaies   BMC BIOLOGY

Global Analysis of mRNA Isoform Half-Lives Reveals Stabilizing and Destabilizing Elements in Yeast

(2014) Joseph V. Geisberg et al.   CELL

3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells

(2014) L. Davidson et al.   GENES & DEVELOPMENT

Binding of the Termination Factor Nsi1 to Its Cognate DNA Site Is Sufficient To Terminate RNA Polymerase I Transcription In Vitro and To Induce Termination In Vivo

(2014) P. Merkl et al.   MOLECULAR AND CELLULAR BIOLOGY

Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics

(2014) Bo Li et al.   NATURAL PRODUCT REPORTS

Structure of the Rpn11–Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradation

(2014) Evan J Worden et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The translation elongation factor eEF1A1 couples transcription to translation during heat shock response

(2014) Maria Vera et al.   eLife

Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1

(2013) V. Nandakumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions

(2012) Sarah Schulz et al.   EMBO REPORTS

The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation

(2011) A. Nijnik et al.   BLOOD

Control of B Cell Development by the Histone H2A Deubiquitinase MYSM1

(2011) Xiao-Xia Jiang et al.   IMMUNITY

Photoadaptation in Neurospora by Competitive Interaction of Activating and Inhibitory LOV Domains

(2010) Erik Malzahn et al.   CELL

Combined chemical and genetic approach to inhibit proteolysis by the proteasome

(2010) Galen A. Collins et al.   YEAST

Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton

(2009) Yifeng Jia et al.   CELL STRESS & CHAPERONES

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

(2009) Eric M Cooper et al.   EMBO JOURNAL

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL

Histone H2A ubiquitination in transcriptional regulation and DNA damage repair

(2008) Wenlai Zhou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Comprehensive Characterization of Heat Shock Protein 27 Phosphorylation in Human Endothelial Cells Stimulated by the Microbial Dithiole Thiolutin

(2008) Shujia Dai et al.   JOURNAL OF PROTEOME RESEARCH

Mechanism and Consequences for Paralog-Specific Sumoylation of Ubiquitin-Specific Protease 25

(2008) Erik Meulmeester et al.   MOLECULAR CELL

Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

(2008) Yusuke Sato et al.   NATURE

Zinc-finger UBPs: regulators of deubiquitylation

(2008) Jacques Bonnet et al.   TRENDS IN BIOCHEMICAL SCIENCES

The transcriptional inhibitor thiolutin blocks mRNA degradation in yeast

(2007) Vicent Pelechano et al.   YEAST