PET Imaging of Microglial Activation—Beyond Targeting TSPO

Evaluation of 4-oxo-quinoline-based CB2 PET radioligands in R6/2 chorea huntington mouse model and human ALS spinal cord tissue

(2018) Ahmed Haider et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

PET imaging of cannabinoid type 2 receptors with [11C]A-836339 did not evidence changes following neuroinflammation in rats

(2017) Geraldine Pottier et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans

(2017) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis

(2017) Wissam Beaino et al.   Journal of Neuroinflammation

In vivo TSPO and cannabinoid receptor type 2 availability early in post-stroke neuroinflammation in rats: a positron emission tomography study

(2017) Teruyo Hosoya et al.   Journal of Neuroinflammation

Evaluation of a novel radiotracer for positron emission tomography imaging of reactive oxygen species in the central nervous system

(2017) Alan A. Wilson et al.   NUCLEAR MEDICINE AND BIOLOGY

Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response

(2017) Junbin Han et al.   NUCLEAR MEDICINE COMMUNICATIONS

Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7

(2017) Enrico Raffaele Fantoni et al.   EJNMMI Research

Radiochemistry on electrodes: Synthesis of an 18F-labelled and in vivo stable COX-2 inhibitor

(2017) Artem Lebedev et al.   PLoS One

Decreased in vivo availability of the cannabinoid type 2 receptor in Alzheimer’s disease

(2016) Rawaha Ahmad et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

The microglial ATP-gated ion channel P2X7 as a CNS drug target

(2016) Anindya Bhattacharya et al.   GLIA

Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor

(2016) Rareş-Petru Moldovan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a fluorinated 4-oxo-quinoline derivative as a potential positron emission tomography radiotracer for imaging cannabinoid receptor type 2

(2016) Roger Slavik et al.   JOURNAL OF NEUROCHEMISTRY

Augmented expression of TSPO after intracerebral hemorrhage: a role in inflammation?

(2016) Frederick Bonsack et al.   Journal of Neuroinflammation

Preclinical Evaluation of a P2X7 Receptor-Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates

(2016) D. Ory et al.   JOURNAL OF NUCLEAR MEDICINE

Characterization of 11 C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation

(2016) Paul R. Territo et al.   JOURNAL OF NUCLEAR MEDICINE

Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders

(2016) Gemma Navarro et al.   Frontiers in Neuroscience

Design, Synthesis, and Evaluation of an18F-Labeled Radiotracer Based on Celecoxib-NBD for Positron Emission Tomography (PET) Imaging of Cyclooxygenase-2 (COX-2)

(2015) Jatinder Kaur et al.   ChemMedChem

Synthesis, radiolabeling and evaluation of novel 4-oxo-quinoline derivatives as PET tracers for imaging cannabinoid type 2 receptor

(2015) Roger Slavik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A 11C-Labeled 1,4-Dihydroquinoline Derivative as a Potential PET Tracer for Imaging of Redox Status in Mouse Brain

(2015) Toshimitsu Okamura et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Discovery of a High Affinity and Selective Pyridine Analog as a Potential Positron Emission Tomography Imaging Agent for Cannabinoid Type 2 Receptor

(2015) Roger Slavik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains

(2015) Douglas G. Walker et al.   Alzheimers Research & Therapy

Imaging of reactive oxygen species using [3H]hydromethidine in mice with cisplatin-induced nephrotoxicity

(2015) Nozomi Takai et al.   EJNMMI Research

Imaging of reactive oxygen species in focal ischemic mouse brain using a radical trapping tracer [3H]hydromethidine

(2015) Kohji Abe et al.   EJNMMI Research

Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation

(2015) Alena V. Savonenko et al.   PLoS One

In Vivo Imaging of Reactive Oxygen Species in Mouse Brain by using [3H]Hydromethidine as a Potential Radical Trapping Radiotracer

(2014) Kohji Abe et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Synthesis and initial preclinical evaluation of the P2X7receptor antagonist [11C]A-740003 as a novel tracer of neuroinflammation

(2014) Bieneke Janssen et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Development of a PET radiotracer for non-invasive imaging of the reactive oxygen species, superoxide, in vivo

(2014) Wenhua Chu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Radiotracers for Molecular Imaging of Cyclooxygenase-2 (COX-2) Enzyme

(2013) O. Tietz et al.   CURRENT MEDICINAL CHEMISTRY

Imaging COX-2 expression in cancer using PET/SPECT radioligands: current status and future directions

(2013) A. Pacelli et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Quantification of the Specific Translocator Protein Signal of 18F-PBR111 in Healthy Humans: A Genetic Polymorphism Effect on In Vivo Binding

(2013) Q. Guo et al.   JOURNAL OF NUCLEAR MEDICINE

P2X7 Receptor Activation Induces Reactive Oxygen Species Formation and Cell Death in Murine EOC13 Microglia

(2013) Rachael Bartlett et al.   MEDIATORS OF INFLAMMATION

Whole-Body Biodistribution and Radiation Dosimetry of the Cannabinoid Type 2 Receptor Ligand [11C]-NE40 in Healthy Subjects

(2013) Rawaha Ahmad et al.   MOLECULAR IMAGING AND BIOLOGY

Small-animal PET imaging of the type 1 and type 2 cannabinoid receptors in a photothrombotic stroke model

(2012) Caroline Vandeputte et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A Genetic Polymorphism for Translocator Protein 18 Kda Affects both in Vitro and in Vivo Radioligand Binding in Human Brain to this Putative Biomarker of Neuroinflammation

(2012) William C Kreisl et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Preclinical evaluation of [11C]NE40, a type 2 cannabinoid receptor PET tracer

(2011) Nele Evens et al.   NUCLEAR MEDICINE AND BIOLOGY

Targeting cyclooxygenases-1 and -2 in neuroinflammation: Therapeutic implications

(2010) Saba Aïd et al.   BIOCHIMIE

Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)

(2010) Andrew G. Horti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Mixed-Affinity Binding in Humans with 18-kDa Translocator Protein Ligands

(2010) D. R. J. Owen et al.   JOURNAL OF NUCLEAR MEDICINE

IL-6 Mediated Degeneration of Forebrain GABAergic Interneurons and Cognitive Impairment in Aged Mice through Activation of Neuronal NADPH Oxidase

(2009) Laura L. Dugan et al.   PLoS One

Characterization of a Cannabinoid CB2 Receptor-Selective Agonist, A-836339 [2,2,3,3-Tetramethyl-cyclopropanecarboxylic Acid [3-(2-Methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], Using in Vitro Pharmacological Assays, in Vivo Pain Models, and Pharmacological Magnetic Resonance Imaging

(2008) B. B. Yao et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS