Article
Chemistry, Physical
Omar Alami, Regis Laurent, Marine Tasse, Yannick Coppel, Vincent Colliere, Jerome Bignon, Jean-Pierre Majoral, Said El Kazzouli, Nabil El Brahmi, Anne-Marie Caminade
Summary: In this study, a novel approach for functionalizing graphene oxide (GO) surface with AB5 phosphorus dendron and dendrimer was reported. These functionalized macromolecules were grafted onto the GO surface via covalent bonding. The resulting materials were characterized and evaluated for their biological activity.
Article
Chemistry, Applied
Sneh Punia Bangar, Kyle Dunno, Sanju Bala Dhull, Anil Kumar Siroha, Sushil Changan, Sajid Maqsood, Alexandru Vasile Rusu
Summary: Avocado seeds are rich in beneficial components such as polysaccharides, proteins, lipids, vitamins, etc. They have been found to have health-promoting properties, including anti-diabetic, anti-cancer, and anti-inflammatory effects. Extracts derived from avocado seeds can be used to develop pharmaceutical, functional food, and nutraceutical products. Further research is needed to confirm the effectiveness of avocado seeds.
Article
Plant Sciences
Jorge M. M. Alves-Silva, Emma Cocco, Alessandra Piras, Maria Jose Goncalves, Ana Silva, Danilo Falconieri, Silvia Porcedda, Maria Teresa Cruz, Andrea Maxia, Ligia Salgueiro
Summary: This study aims to uncover the chemical composition and properties of the essential oil from Salvia cacaliifolia Benth. It was found that the essential oil has antifungal and anti-inflammatory effects, as well as the ability to promote wound healing and prevent aging. These findings highlight the potential of Salvia cacaliifolia essential oil for the development of sustainable and environmentally friendly skin products.
Article
Biochemistry & Molecular Biology
Gokhan Zengin, Mohamad Fawzi Mahomoodally, Kouadio Ibrahime Sinan, Gunes Ak, Ouattara Katinan Etienne, Jugreet B. Sharmeen, Luigi Brunetti, Sheila Leone, Simonetta Cristina Di Simone, Lucia Recinella, Annalisa Chiavaroli, Luigi Menghini, Giustino Orlando, Jozsef Jeko, Zoltan Cziaky, Claudio Ferrante
Summary: The present study investigated the phytochemical contents and biological potential of leaf and stem bark extracts of Jatropha species as antioxidants, enzyme inhibitors, and neuromodulators, revealing their significant pharmacological potentials with high antioxidant capacity and various therapeutic properties.
Article
Materials Science, Paper & Wood
Muhammed Said Fidan, Cemalettin Baltaci, Mehmet Oz, Zeynep Akar
Summary: The study investigated the vitamin C, enzyme activities, phenolic compounds, antioxidant capacity, antimicrobial activity, and essential oil analyses of ripe and unripe fruits of P. terebinthus. The methanol extracts obtained from the ripe fruits showed higher antioxidant properties and antimicrobial activity than those obtained from the unripe fruits. The main components in the essential oils were monoterpenoids, sesquiterpenes, and monoterpenes in unripe and ripe fruits, respectively, with α-pinene being the dominant compound.
Article
Chemistry, Medicinal
Sonia P. Miguel, Caique D'Angelo, Maximiano P. Ribeiro, Rogerio Simoes, Paula Coutinho
Summary: This study characterized crude polysaccharides extracted from Codium sp. and Osmundea sp. macroalgae collected in different seasons from the Galician and North Portugal coasts, aiming to support their biomedical application to wound healing. The results showed that the sulphate content of the polysaccharides increased from winter to summer, with higher values for Osmundea sp. The monosaccharide composition also changed with seasons, with a decrease in glucose content in Osmundea sp. from spring to winter. Galactose was the major monosaccharide in all samples, remaining stable across seasons and collection sites.
Article
Biochemistry & Molecular Biology
Miroslava Kacaniova, Nenad L. Vukovic, Natalia Cmikova, Lucia Galovicova, Marianna Schwarzova, Veronika Simora, Przemyslaw Lukasz Kowalczewski, Maciej Ireneusz Kluz, Czeslaw Puchalski, Ladislav Bakay, Milena D. Vukic
Summary: This study analyzed the chemical composition and various properties of Salvia sclarea essential oil (SSEO). The results showed that SSEO has moderate antimicrobial and antibiofilm activities, as well as insecticidal potential. The study also identified the main constituents of SSEO and their antioxidant activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Ewa Stodolak-Zych, Agnieszka Gubernat, Anna Scislowska-Czarnecka, Magdalena Chadzinska, Lukasz Zych, Dariusz Zientara, Marek Nocun, Piotr Jelen, Miroslaw M. Bucko
Summary: This study aimed to explain the differences in the biological behavior of two boron carbide powders prepared by different synthesis methods. The results showed that the synthesized powder had a higher boron content and facilitated protein adsorption, leading to increased hydrophilicity and improved cell adhesion.
APPLIED SURFACE SCIENCE
(2022)
Article
Plant Sciences
Natalia Cmikova, Lucia Galovicova, Marianna Schwarzova, Milena D. Vukic, Nenad L. Vukovic, Przemyslaw Lukasz Kowalczewski, Ladislav Bakay, Maciej Ireneusz Kluz, Czeslaw Puchalski, Miroslava Kacaniova
Summary: This study analyzed the chemical composition and various biological activities of Eucalyptus globulus essential oil (EGEO). The main components of EGEO were identified as 1,8-cineole, p-cimene, α-pinene, and α-limonene. The results showed that EGEO exhibited significant antimicrobial, antibiofilm, antioxidant, and insecticidal activities.
Article
Chemistry, Physical
Faezeh Najafi, Mehdi Salami-Kalajahi, Hossein Roghani-Mamaqani
Summary: Janus dendrimers are multifaceted systems with unique structure and properties, combining different types of end-groups on different parts of the surface. They have enhanced solubility, electrochemical properties, and self-assembly ability, distinguishing themselves from conventional dendrimers. The broken symmetry structure of Janus dendrimers offers new features for forming complex materials. They find applications in various fields including ionic liquids, bioimaging, catalysis, smart systems, drug suspensions, hydrogels, and cancer therapy.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Polymer Science
R. M. England, S. Sonzini, D. Buttar, K. E. Treacher, M. B. Ashford
Summary: This study characterized poly(l-lysine) dendrimers using advanced analytical techniques and molecular dynamics simulations. The results showed an increase in refractive index and intrinsic viscosity in the early generations of the dendrimers, which decreased in later generations. The protected dendrimers had different molecular density profiles compared to the unprotected dendrimers, possibly due to electrostatic repulsion. This research provides valuable insights into the structure and properties of PLL dendrimers for drug delivery applications.
Article
Food Science & Technology
Xinyu Yu, Xinyue Tu, Lingchen Tao, Jayasimha Daddam, Shanshan Li, Fuliang Hu
Summary: This review summarizes the current knowledge on the chemical composition, extraction methods, and biological activities of royal jelly fatty acids, providing a theoretical basis for expanding prospective applications of royal jelly in human health.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Chemistry, Multidisciplinary
Sarah Tassinari, Silvia Moreno, Hartmut Komber, Riccardo Carloni, Michela Cangiotti, Maria Francesca Ottaviani, Dietmar Appelhans
Summary: This study demonstrates the potential of glycodendrimers and oligopeptides in inhibiting the formation of immunocomplexes and breaking down preformed immunocomplexes in Systemic Lupus Erythematosus (SLE). The 3(rd) generation poly(propyleneimine) (PPI) dendrimer exhibits the most promising anti-SLE activity.
Article
Plant Sciences
Zvonimir Jazo, Mateo Glumac, Vlatka Pastar, Sanida Bektic, Mila Radan, Ivana Carev
Summary: In this study, the chemical composition and cytotoxic activity of essential oils from Dalmatian sage collected in Croatia were investigated. The essential oils were found to contain terpene compounds, including thujone, camphor, and 1,8-cineol. Cytotoxic activity was tested on multiple cell lines, with the lung line being the least resistant and the fibroblasts being the most resistant. The study provides valuable information on the pharmacotherapeutic potential of S. officinalis EO.
Article
Biochemistry & Molecular Biology
Shanoo Suroowan, E. J. Llorent-Martinez, Gokhan Zengin, Asaad Khalid, Ashraf N. Abdalla, Soud Khogeer, Bao Van, Mohamad Fawzi Mahomoodally
Summary: This study investigated the phytochemical and pharmacological properties of Wikstroemia indica. The methanolic extract showed the highest content of phenolic compounds and exhibited the strongest antioxidant potential. The ethyl acetate extract and methanolic extract demonstrated good inhibitory activity against acetylcholinesterase, and the ethyl acetate extract also showed activity against butyrylcholinesterase. The tyrosinase and alpha amylase inhibitory potentials were confirmed, and the aqueous extract showed cytotoxicity against HT 29 cells.
PROCESS BIOCHEMISTRY
(2023)
Review
Nanoscience & Nanotechnology
Anne-Marie Caminade, Cedric-Olivier Turrin, Remy Poupot
Summary: Different types of water-soluble phosphorous dendrimers with various biological properties, such as stimulating the immune system and displaying anti-inflammatory effects, have been synthesized. These dendrimers have shown potential in the treatment of chronic or acute inflammatory diseases and hematological cancers in animal models. Safety assessments have demonstrated their hematological safety both in mice and non-human primates.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Evgeny Apartsin, Alya Venyaminova, Jean-Pierre Majoral, Anne-Marie Caminade
Summary: This study presents the method of impregnating neutral hydrogels with siRNA-dendrimer complexes, where the surface chemistry of dendrimers allows adjustment of the release rate. This provides a new material for biomedical applications.
FRONTIERS IN CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Evgeny K. Apartsin, Nadezhda Knauer, Ulf Dietrich Kahlert, Anne-Marie Caminade
Summary: Dendritic molecules with metal complexes are potential therapeutic entities, and metallodendrons are particularly of interest as antitumor agents. In this study, we synthesized amphiphilic metallodendrons and tested their antitumor activity against glioblastoma. The results showed that the metallodendrons exhibited higher cytotoxic activity compared to the clinical standard of care for glioblastoma, indicating their potential as antitumor entities.
Meeting Abstract
Oncology
N. Knauer, E. Pashkina, V. Kozlov, R. Gomez, A-M. Caminade, U. Kahlert, E. Apartsin
ANNALS OF ONCOLOGY
(2022)
Article
Materials Science, Biomaterials
Liang Chen, Mengsi Zhan, Jin Li, Liu Cao, Huxiao Sun, Regis Laurent, Serge Mignani, Anne-Marie Caminade, Jean-Pierre Majoral, Xiangyang Shi
Summary: This study introduces a nanosystem based on amphiphilic phosphorus dendron micelles for combination therapy of triple negative breast cancer. The micelles exhibit excellent stability and high drug loading efficiency. The co-delivery system of miR-21 inhibitor and doxorubicin can effectively inhibit cancer cells through different anticancer mechanisms, as demonstrated in in vivo experiments.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Materials Science, Composites
Evgeny Apartsin, Anne-Marie Caminade
Summary: This article reviews different types of amphiphilic dendritic structures, including dendrimers, Janus dendrimers, and dendrons, which can individually generate physical hydrogels. It has been found that these structures can be prospective building blocks for hydrogel networks. The first part introduces positively charged phosphorus dendrimers used to generate hydrogels, which are also suitable for fiber formation, encapsulating substances, and forming complexes for slow delivery of genetic materials. The second part discusses PAMAM dendrimers functionalized with collagen mimetics. The third part focuses on amphiphilic Janus dendrimers, while the fourth part displays different types of amphiphilic dendrons and their use in the fields of materials and drug delivery.
JOURNAL OF COMPOSITES SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Anne-Marie Caminade, Aurelien Hameau, Kathleen Moineau-Chane Ching, Cedric-Olivier Turrin
Summary: This review presents the synthesis of dendrons based on cyclotriphosphazene cores, with one function being a fluorescent group, and the five remaining functions used for growing the dendritic branches. The growing of the branches is carried out by a divergent method using a two-step process. Different fluorophores and terminal functions of the dendrons lead to various applications, including catalysis, material elaboration, transfection experiments, anti-cancer property study, and imaging related to the human immune system.
HELVETICA CHIMICA ACTA
(2023)
Review
Chemistry, Multidisciplinary
Valerie Maraval, Regis Laurent, Anne-Marie Caminade
Summary: The Staudinger reaction is used for the synthesis of phosphorus azides and dendritic structures containing P=N-P=X moieties. The conjugation of P=N bond with P=X bond stabilizes the P=N bond. Various dendritic structures such as dendrons, dendrimers, Janus dendrimers, layered dendrimers, surface-block dendrimers, etc. have been synthesized using this reaction. Alkylation or complexation exclusively occurs on the sulfur atom of P=N-P=S linkages, weakening the strength of P=S bond and allowing the formation of highly sophisticated dendritic structures.
Editorial Material
Health Care Sciences & Services
Anne-Marie Caminade
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Omar Alami, Regis Laurent, Marine Tasse, Yannick Coppel, Jerome Bignon, Said El Kazzouli, Jean-Pierre Majoral, Nabil El Brahmi, Anne-Marie Caminade
Summary: In this study, two families of phosphorhydrazone dendrons were synthesized and characterized. These dendrons were then grafted onto graphene oxide (GO) via click reaction. The resulting materials were tested for their biological properties.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Anne-Marie Caminade
Summary: This review provides an overview of the interactions between two different families of nanoobjects: nanoparticles, mainly metal nanoparticles, and dendrimers, mainly phosphorhydrazone dendrimers (or dendrons). The review discusses the encapsulation/protection of existing nanoparticles (organic or metallic) by phosphorus-based dendrimers and dendrons. It also presents various methods for synthesizing metal nanoparticles using dendrimers as templates. The review emphasizes the properties of the associations between dendrimers and nanoparticles, including their application in hybrid materials, chemosensors, biosensors, and catalysis.
Review
Biochemistry & Molecular Biology
Joel Cejas-Sanchez, Anna Kajetanowicz, Karol Grela, Anne-Marie Caminade, Rosa Maria Sebastian
Summary: Dendrimers are highly branched macromolecules with identical terminal functionalities, but there are cases where having two distinct surface functionalities is advantageous. Janus dendrimers, consisting of two dendrimeric wedges terminated by different functionalities, can be created by synthesizing dendrons with complementary core functionalities. This review discusses various techniques used to fabricate phosphorus-based Janus dendrimers and highlights the advantages of phosphorus dendrimers over classic dendrimers, such as easy monitoring of reactions and purity confirmation through P-31 NMR.
Review
Pharmacology & Pharmacy
Anne-Marie Caminade, Max Milewski, Evamarie Hey-Hawkins
Summary: The use of boron clusters in nanoparticles for cancer treatment, particularly in dendrimers, is highlighted in this review. The synthesis methods and biological properties of boronated dendritic structures are discussed, along with their efficiency in animal models and potential for boron neutron capture therapy (BNCT) experiments.
Article
Chemistry, Physical
Omar Alami, Regis Laurent, Marine Tasse, Yannick Coppel, Vincent Colliere, Jerome Bignon, Jean-Pierre Majoral, Said El Kazzouli, Nabil El Brahmi, Anne-Marie Caminade
Summary: In this study, a novel approach for functionalizing graphene oxide (GO) surface with AB5 phosphorus dendron and dendrimer was reported. These functionalized macromolecules were grafted onto the GO surface via covalent bonding. The resulting materials were characterized and evaluated for their biological activity.
Article
Chemistry, Multidisciplinary
Hanna Dib, Jeremy Rebiere, Cyrille Rebout, Omar Alami, Said El Kazzouli, Nabil El Brahmi, Regis Laurent, Beatrice Delavaux-Nicot, Anne-Marie Caminade
Summary: This study reports a method for synthesizing dendritic structures using difunctional polyethylene glycols (PEGs) as core, where the second and third level of branching units are constituted of phosphorhydrazone linkages. It was found that the growth rate was faster and did not stop when PEG(300) was used as core.
RESULTS IN CHEMISTRY
(2022)
