The Protective Effects of a Synthetic Geranyl Acetophenone in a Cellular Model of TNF-α-Induced Pulmonary Epithelial Barrier Dysfunction

An orally active geranyl acetophenone attenuates airway remodeling in a murine model of chronic asthma

(2017) Yu Zhao Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Pivotal Role of CXCR7 in Stabilization of the Pulmonary Epithelial Barrier in Acute Pulmonary Inflammation

(2017) Kristian-Christos Ngamsri et al.   JOURNAL OF IMMUNOLOGY

Anti-allergic activity of 2,4,6-trihydroxy-3-geranylacetophenone (tHGA) via attenuation of IgE-mediated mast cell activation and inhibition of passive systemic anaphylaxis

(2017) Ji Wei Tan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

C2-ceramide influences alveolar epithelial barrier function by downregulating Zo-1, occludin and claudin-4 expression

(2017) Jin Yang et al.   TOXICOLOGY MECHANISMS AND METHODS

C2-ceramide influences alveolar epithelial barrier function by downregulating Zo-1, occludin and claudin-4 expression

(2017) Jin Yang et al.   TOXICOLOGY MECHANISMS AND METHODS

Blockade of Eosinophil-Induced Bronchial Epithelial-Mesenchymal Transition with a Geranyl Acetophenone in a Coculture Model

(2017) Yu Z. Lee et al.   Frontiers in Pharmacology

FXYD5 Is an Essential Mediator of the Inflammatory Response during Lung Injury

(2017) Patricia L. Brazee et al.   Frontiers in Immunology

Carbocisteine attenuates TNF-α-induced inflammation in human alveolar epithelial cells in vitro through suppressing NF-κB and ERK1/2 MAPK signaling pathways

(2016) Wei Wang et al.   ACTA PHARMACOLOGICA SINICA

Glucocorticoids Regulate Tight Junction Permeability of Lung Epithelia by Modulating Claudin 8

(2016) Felix Kielgast et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Δ9-Tetrahydrocannabinol reverses TNFα-induced increase in airway epithelial cell permeability through CB2 receptors

(2016) Valerie C.M. Shang et al.   BIOCHEMICAL PHARMACOLOGY

Whey protein concentrate enhances intestinal integrity and influences transforming growth factor-β1 and mitogen-activated protein kinase signalling pathways in piglets after lipopolysaccharide challenge

(2016) Kan Xiao et al.   BRITISH JOURNAL OF NUTRITION

On the Dependency of Cellular Protein Levels on mRNA Abundance

(2016) Yansheng Liu et al.   CELL

β1-Na+,K+-ATPase gene therapy upregulates tight junctions to rescue lipopolysaccharide-induced acute lung injury

(2016) X Lin et al.   GENE THERAPY

Barrier protective effects of 2,4,6-trihydroxy-3-geranyl acetophenone on lipopolysaccharides-stimulated inflammatory responses in human umbilical vein endothelial cells

(2016) Yi Joong Chong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Tight junctions in pulmonary epithelia during lung inflammation

(2016) Oliver H. Wittekindt   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Inhibition of Acute Lung Injury by TNFR-Fc through Regulation of an Inflammation-Oxidative Stress Pathway

(2016) Yuan Weifeng et al.   PLoS One

Angiotensin-converting enzyme 2 prevents lipopolysaccharide-induced rat acute lung injury via suppressing the ERK1/2 and NF-κB signaling pathways

(2016) Yingchuan Li et al.   Scientific Reports

p120-Catenin Expressed in Alveolar Type II Cells Is Essential for the Regulation of Lung Innate Immune Response

(2015) Andreia Z. Chignalia et al.   AMERICAN JOURNAL OF PATHOLOGY

Pulmonary epithelial barrier function: some new players and mechanisms

(2015) Kieran Brune et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity

(2015) Joshua A. Englert et al.   ANESTHESIOLOGY

High glucose-induced intestinal epithelial barrier damage is aggravated by syndecan-1 destruction and heparanase overexpression

(2015) Qing Qing et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Next-generation analysis of gene expression regulation – comparing the roles of synthesis and degradation

(2015) Joel McManus et al.   Molecular BioSystems

Vitamin D/VDR signaling attenuates lipopolysaccharide-induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier

(2015) YONG-YAN SHI et al.   Molecular Medicine Reports

Resolvins Decrease Oxidative Stress Mediated Macrophage and Epithelial Cell Interaction through Decreased Cytokine Secretion

(2015) Ruan Cox et al.   PLoS One

Cigarette Smoke–Induced Disruption of Bronchial Epithelial Tight Junctions Is Prevented by Transforming Growth Factor-β

(2014) Andrea C. Schamberger et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Regulation of Epithelial Cell Tight Junctions by Protease-Activated Receptor 2

(2014) Shuhei ENJOJI et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Effects of Human Parvovirus B19 and Bocavirus VP1 Unique Region on Tight Junction of Human Airway Epithelial A549 Cells

(2014) Chun-Ching Chiu et al.   PLoS One

Upregulation of the tight junction protein occludin: effects on ventilation-induced lung injury and mechanisms of action

(2014) Mengjie Liu et al.   BMC Pulmonary Medicine

Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction

(2013) Susanne Herold et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cyclic Stretch–Induced Oxidative Stress Increases Pulmonary Alveolar Epithelial Permeability

(2013) Nurit Davidovich et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Gene Copy-Number Alterations: A Cost-Benefit Analysis

(2013) Yun-Chi Tang et al.   CELL

TNF-α–mediated bronchial barrier disruption and regulation by src-family kinase activation

(2013) Michelle A. Hardyman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Resolvin D1 reduces deterioration of tight junction proteins by upregulating HO-1 in LPS-induced mice

(2013) Wanli Xie et al.   LABORATORY INVESTIGATION

Curcumin Nanoparticles Ameliorate ICAM-1 Expression in TNF-α-Treated Lung Epithelial Cells through p47 phox and MAPKs/AP-1 Pathways

(2013) Feng-Lin Yen et al.   PLoS One

p38 MAPK mediates calcium oxalate crystal-induced tight junction disruption in distal renal tubular epithelial cells

(2013) Paleerath Peerapen et al.   Scientific Reports

Overexpression of Tumor Necrosis Factor-α in the Lungs Alters Immune Response, Matrix Remodeling, and Repair and Maintenance Pathways

(2012) Errol M. Thomson et al.   AMERICAN JOURNAL OF PATHOLOGY

Map kinase phosphatase 5 protects against sepsis-induced acute lung injury

(2012) Feng Qian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements

(2012) Lucy W. Barrett et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The effect of magnolol on the toll-like receptor 4/nuclear factor kappa B signaling pathway in lipopolysaccharide-induced acute lung injury in mice

(2012) Fu Yunhe et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The acute respiratory distress syndrome

(2012) Michael A. Matthay et al.   JOURNAL OF CLINICAL INVESTIGATION

Cytokines induce tight junction disassembly in airway cells via an EGFR-dependent MAPK/ERK1/2-pathway

(2012) Loredana Petecchia et al.   LABORATORY INVESTIGATION

Tight Junction-Related Barrier Contributes to the Electrophysiological Asymmetry across Vocal Fold Epithelium

(2012) Qianru Zhang et al.   PLoS One

Hyperoxia disrupts pulmonary epithelial barrier in newborn rats via the deterioration of occludin and ZO-1

(2012) Kai You et al.   RESPIRATORY RESEARCH

A geranyl acetophenone targeting cysteinyl leukotriene synthesis prevents allergic airway inflammation in ovalbumin-sensitized mice

(2012) Norazren Ismail et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Claudin-4 Levels Are Associated with Intact Alveolar Fluid Clearance in Human Lungs

(2011) Deepti Rokkam et al.   AMERICAN JOURNAL OF PATHOLOGY

Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase

(2011) Khozirah Shaari et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Upstream open reading frames: Molecular switches in (patho)physiology

(2010) Klaus Wethmar et al.   BIOESSAYS

Reduction of Monocyte Chemoattractant Protein-1 and Interleukin-8 Levels by Ticlopidine in TNF-αStimulated Human Umbilical Vein Endothelial Cells

(2010) Chaur-Jong Hu et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Cultured Alveolar Epithelial Cells From Septic Rats Mimic In Vivo Septic Lung

(2010) Taylor S. Cohen et al.   PLoS One

Inhibition of the MAP kinase ERK protects from lipopolysaccharide-induced lung injury

(2009) Katrin Schuh et al.   BIOCHEMICAL PHARMACOLOGY

Critical role of p38 mitogen-activated protein kinase signaling in septic lung injury*

(2009) Muhammad Asaduzzaman et al.   CRITICAL CARE MEDICINE

Characterisation of cell adhesion in airway epithelial cell types using electric cell-substrate impedance sensing

(2009) I. H. Heijink et al.   EUROPEAN RESPIRATORY JOURNAL

LXA4 stimulates ZO-1 expression and transepithelial electrical resistance in human airway epithelial (16HBE14o-) cells

(2008) Yael Grumbach et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

p38MAPK inhibition attenuates LPS-induced acute lung injury involvement of NF-κB pathway

(2008) Su Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TNF-α-induced up-regulation of intercellular adhesion molecule-1 is regulated by a Rac-ROS-dependent cascade in human airway epithelial cells

(2008) Hyunju Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Role of the pulmonary epithelium and inflammatory signals in acute lung injury

(2008) Anne M Manicone   Expert Review of Clinical Immunology

Crosstalk of tight junction components with signaling pathways

(2007) Lorenza González-Mariscal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES