Design, Synthesis, and Evaluation of Novel Immunomodulatory Small Molecules Targeting the CD40–CD154 Costimulatory Protein-Protein Interaction
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Title
Design, Synthesis, and Evaluation of Novel Immunomodulatory Small Molecules Targeting the CD40–CD154 Costimulatory Protein-Protein Interaction
Authors
Keywords
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Journal
MOLECULES
Volume 23, Issue 5, Pages 1153
Publisher
MDPI AG
Online
2018-05-14
DOI
10.3390/molecules23051153
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- (2016) Axel Hoos NATURE REVIEWS DRUG DISCOVERY
- Small molecules, big targets: drug discovery faces the protein–protein interaction challenge
- (2016) Duncan E. Scott et al. NATURE REVIEWS DRUG DISCOVERY
- TNF Superfamily Protein-Protein Interactions: Feasibility of Small- Molecule Modulation
- (2015) Yun Song et al. CURRENT DRUG TARGETS
- Prevention and Reversal of Type 1 Diabetes—Past Challenges and Future Opportunities
- (2015) Jay S. Skyler DIABETES CARE
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- (2014) Lech-Gustav Milroy et al. CHEMICAL REVIEWS
- Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality
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- (2014) J. H. Xie et al. JOURNAL OF IMMUNOLOGY
- Effects of representative glucocorticoids on TNFα- and CD40L-induced NF-κB activation in sensor cells
- (2014) Sirlene R. Cechin et al. STEROIDS
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- (2013) Mark A Atkinson et al. LANCET
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- Challenges and approaches for the development of safer immunomodulatory biologics
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- Patient preferences and willingness to pay for different options of anticoagulant therapy
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- Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism
- (2011) Laura F. Silvian et al. ACS Chemical Biology
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- (2011) Lakshmi Ganesan et al. BIOCHEMICAL PHARMACOLOGY
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- (2007) Benjamin Leader et al. NATURE REVIEWS DRUG DISCOVERY
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