Small-molecule modulators of the OX40-OX40 ligand co-stimulatory protein-protein interaction

Antagonism of Airway Tolerance by Endotoxin/Lipopolysaccharide through Promoting OX40L and Suppressing Antigen-Specific Foxp3+ T Regulatory Cells

(2014) W. Duan et al.   JOURNAL OF IMMUNOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: Catalytic Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Diametric Role for OX40 in the Response of Effector/Memory CD4+ T Cells and Regulatory T Cells to Alloantigen

(2013) G. Kinnear et al.   JOURNAL OF IMMUNOLOGY

Industry pursues co-stimulatory receptor immunomodulators to treat cancer

(2013) Cormac Sheridan   NATURE BIOTECHNOLOGY

Advances in targeting cell surface signalling molecules for immune modulation

(2013) Sheng Yao et al.   NATURE REVIEWS DRUG DISCOVERY

Clinical targeting of the TNF and TNFR superfamilies

(2013) Michael Croft et al.   NATURE REVIEWS DRUG DISCOVERY

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Stabilization and Inhibition of Protein–Protein Interactions: The 14-3-3 Case Study

(2012) Lech-Gustav Milroy et al.   ACS Chemical Biology

Small-molecule modulators of 14-3-3 protein–protein interactions

(2012) Christian Ottmann   BIOORGANIC & MEDICINAL CHEMISTRY

Small-molecule activation of the TRAIL receptor DR5 in human cancer cells

(2012) Gelin Wang et al.   Nature Chemical Biology

OX40 signaling favors the induction of TH9 cells and airway inflammation

(2012) Xiang Xiao et al.   NATURE IMMUNOLOGY

Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism

(2011) Laura F. Silvian et al.   ACS Chemical Biology

The food colorant erythrosine is a promiscuous protein–protein interaction inhibitor

(2011) Lakshmi Ganesan et al.   BIOCHEMICAL PHARMACOLOGY

Science gone translational: the OX40 agonist story

(2011) Andrew D. Weinberg et al.   IMMUNOLOGICAL REVIEWS

Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment

(2011) Damien Bresson et al.   JOURNAL OF AUTOIMMUNITY

Identification and Structure of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions

(2010) Rolf Rose et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Control of Immunity by the TNFR-Related Molecule OX40 (CD134)

(2010) Michael Croft   Annual Review of Immunology

Research Article: Effective and Specific Inhibition of the CD40-CD154 Costimulatory Interaction by a Naphthalenesulphonic Acid Derivative

(2010) Emilio Margolles-Clark et al.   Chemical Biology & Drug Design

Small-molecule protein-protein interaction inhibitors: Therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations

(2010) Peter Buchwald   IUBMB LIFE

OX40 is required for regulatory T cell–mediated control of colitis

(2010) Thibault Griseri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Suramin inhibits the CD40–CD154 costimulatory interaction: A possible mechanism for immunosuppressive effects

(2009) Emilio Margolles-Clark et al.   BIOCHEMICAL PHARMACOLOGY

The TNF superfamily in 2009: new pathways, new indications, and new drugs

(2009) Malú G. Tansey et al.   DRUG DISCOVERY TODAY

The significance of OX40 and OX40L to T-cell biology and immune disease

(2009) Michael Croft et al.   IMMUNOLOGICAL REVIEWS

Cutting Edge: OX40 Agonists Can Drive Regulatory T Cell Expansion if the Cytokine Milieu Is Right

(2009) C. E. Ruby et al.   JOURNAL OF IMMUNOLOGY

Small-molecule costimulatory blockade: organic dye inhibitors of the CD40–CD154 interaction

(2009) Emilio Margolles-Clark et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Assembling OX40 Aptamers on a Molecular Scaffold to Create a Receptor-Activating Aptamer

(2008) Claudia M. Dollins et al.   CHEMISTRY & BIOLOGY

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

(2008) Silvia Piconese et al.   JOURNAL OF EXPERIMENTAL MEDICINE

OX40 Controls Islet Allograft Tolerance in CD154 Deficient Mice by Regulating FOXP3+ Tregs

(2008) Ming Chen et al.   TRANSPLANTATION