The ASD Living Biology: from cell proliferation to clinical phenotype

Maternal IL-17A in autism

(2018) Helen Wong et al.   EXPERIMENTAL NEUROLOGY

Toward a conceptual framework for early brain and behavior development in autism

(2017) J Piven et al.   MOLECULAR PSYCHIATRY

Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder

(2017) M V Lombardo et al.   MOLECULAR PSYCHIATRY

Prenatal fever and autism risk

(2017) M Hornig et al.   MOLECULAR PSYCHIATRY

MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling

(2017) N Mellios et al.   MOLECULAR PSYCHIATRY

Early brain development in infants at high risk for autism spectrum disorder

(2017) Heather Cody Hazlett et al.   NATURE

Reversing behavioural abnormalities in mice exposed to maternal inflammation

(2017) Yeong Shin Yim et al.   NATURE

Refining the role of de novo protein-truncating variants in neurodevelopmental disorders by using population reference samples

(2017) Jack A Kosmicki et al.   NATURE GENETICS

Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases

(2017) Holly A F Stessman et al.   NATURE GENETICS

Germline Chd8 haploinsufficiency alters brain development in mouse

(2017) Andrea L Gompers et al.   NATURE NEUROSCIENCE

SHANK proteins: roles at the synapse and in autism spectrum disorder

(2017) Patricia Monteiro et al.   NATURE REVIEWS NEUROSCIENCE

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

(2017) Michael J. McConnell et al.   SCIENCE

Autism as an adaptive common variant pathway for human brain development

(2017) Mark H. Johnson   Developmental Cognitive Neuroscience

Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment

(2017) D Mattei et al.   Translational Psychiatry

Somatic overgrowth disorders of the PI3K/AKT/mTOR pathway & therapeutic strategies

(2016) Kim M. Keppler-Noreuil et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Eye Tracking Reveals Abnormal Visual Preference for Geometric Images as an Early Biomarker of an Autism Spectrum Disorder Subtype Associated With Increased Symptom Severity

(2016) Karen Pierce et al.   BIOLOGICAL PSYCHIATRY

Diffusion Tensor Imaging Provides Evidence of Possible Axonal Overconnectivity in Frontal Lobes in Autism Spectrum Disorder Toddlers

(2016) Stephanie Solso et al.   BIOLOGICAL PSYCHIATRY

Maternal infection during pregnancy and risk of autism spectrum disorders: A systematic review and meta-analysis

(2016) Hai-yin Jiang et al.   BRAIN BEHAVIOR AND IMMUNITY

AKT in cancer: new molecular insights and advances in drug development

(2016) Prabhjot S. Mundi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The neuroanatomy of autism - a developmental perspective

(2016) Alex P. A. Donovan et al.   JOURNAL OF ANATOMY

Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis

(2016) Li Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Brain Development and Akt Signaling: the Crossroads of Signaling Pathway and Neurodevelopmental Diseases

(2016) Long Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

To Screen or Not to Screen Universally for Autism is not the Question: Why the Task Force Got It Wrong

(2016) Karen Pierce et al.   JOURNAL OF PEDIATRICS

Transgenerational transmission and modification of pathological traits induced by prenatal immune activation

(2016) U Weber-Stadlbauer et al.   MOLECULAR PSYCHIATRY

Altered proliferation and networks in neural cells derived from idiopathic autistic individuals

(2016) M C Marchetto et al.   MOLECULAR PSYCHIATRY

Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder

(2016) Arjun Krishnan et al.   NATURE NEUROSCIENCE

The Role of the Immune System in Autism Spectrum Disorder

(2016) Amory Meltzer et al.   NEUROPSYCHOPHARMACOLOGY

Neocortical neurogenesis and the etiology of autism spectrum disorder

(2016) Alan Packer   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction

(2016) Zhen-Ning Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal immune activation: Implications for neuropsychiatric disorders

(2016) M. L. Estes et al.   SCIENCE

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

(2016) G. B. Choi et al.   SCIENCE

Prenatal Neurogenesis in Autism Spectrum Disorders

(2016) Gaurav Kaushik et al.   Frontiers in Chemistry

Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling

(2016) Ya Wen et al.   PLoS One

Autistic and Rett-like features associated with 2q33.3-q34 interstitial deletion

(2015) Dae-Hyun Jang et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Developmental trajectories as autism phenotypes

(2015) Catherine Lord et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder

(2015) Haruhisa Ohta et al.   Autism Research

The role of STAT3 in autophagy

(2015) Liangkun You et al.   Autophagy

PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia

(2015) Laura A. Jansen et al.   BRAIN

Impaired synaptic development in a maternal immune activation mouse model of neurodevelopmental disorders

(2015) Pierluca Coiro et al.   BRAIN BEHAVIOR AND IMMUNITY

Maternal hospitalization with infection during pregnancy and risk of autism spectrum disorders

(2015) Brian K. Lee et al.   BRAIN BEHAVIOR AND IMMUNITY

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Maternal immune activation induces GAD1 and GAD2 promoter remodeling in the offspring prefrontal cortex

(2015) Marie Anaïs Labouesse et al.   Epigenetics

Clinical phenotype of the recurrent 1q21.1 copy-number variant

(2015) Raphael Bernier et al.   GENETICS IN MEDICINE

Mesenchymal stem cells for the treatment of neurological diseases: Immunoregulation beyond neuroprotection

(2015) Alice Laroni et al.   IMMUNOLOGY LETTERS

Constitutive activation of STAT3 in breast cancer cells: A review

(2015) Kasturi Banerjee et al.   INTERNATIONAL JOURNAL OF CANCER

Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism

(2015) K. M. Huber et al.   JOURNAL OF NEUROSCIENCE

Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated  -Catenin Signaling

(2015) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

Cell cycle networks link gene expression dysregulation, mutation, and brain maldevelopment in autistic toddlers

(2015) T. Pramparo et al.   Molecular Systems Biology

Excess of rare, inherited truncating mutations in autism

(2015) Niklas Krumm et al.   NATURE GENETICS

Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms

(2015) Alissa M. D’Gama et al.   NEURON

Review: Cortical construction in autism spectrum disorder: columns, connectivity and the subplate

(2015) Jeffrey J. Hutsler et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Head circumference and brain size in autism spectrum disorder: A systematic review and meta-analysis

(2015) Roberto Sacco et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders

(2015) M. Sahin et al.   SCIENCE

Excitatory/inhibitory imbalance in autism spectrum disorders: Implications for interventions and therapeutics

(2015) Genoveva Uzunova et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

STAT3 acts through pre-existing nucleosome-depleted regions bound by FOS during an epigenetic switch linking inflammation to cancer

(2015) Joseph D Fleming et al.   Epigenetics & Chromatin

Selective Role of the Catalytic PI3K Subunit p110β in Impaired Higher Order Cognition in Fragile X Syndrome

(2015) Christina Gross et al.   Cell Reports

Increased Expression of the PI3K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome

(2015) Christina Gross et al.   Cell Reports

Wnt Signaling Regulates Multipolar-to-Bipolar Transition of Migrating Neurons in the Cerebral Cortex

(2015) Michael Boitard et al.   Cell Reports

Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model

(2015) Jane C Naviaux et al.   Molecular Autism

Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders

(2014) Dalila Pinto et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Longitudinal Volumetric Brain Changes in Autism Spectrum Disorder Ages 6-35 Years

(2014) Nicholas Lange et al.   Autism Research

Longitudinal changes in cortical thickness in autism and typical development

(2014) Brandon A. Zielinski et al.   BRAIN

Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development

(2014) Raphael Bernier et al.   CELL

Dysregulation of the IGF-I/PI3K/AKT/mTOR signaling pathway in autism spectrum disorders

(2014) Jianling Chen et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Synaptic, transcriptional and chromatin genes disrupted in autism

(2014) Silvia De Rubeis et al.   NATURE

The contribution of de novo coding mutations to autism spectrum disorder

(2014) Ivan Iossifov et al.   NATURE

Most genetic risk for autism resides with common variation

(2014) Trent Gaugler et al.   NATURE GENETICS

Patches of Disorganization in the Neocortex of Children with Autism

(2014) Rich Stoner et al.   NEW ENGLAND JOURNAL OF MEDICINE

CHD8regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors

(2014) Aarathi Sugathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

A de novo convergence of autism genetics and molecular neuroscience

(2014) Niklas Krumm et al.   TRENDS IN NEUROSCIENCES

Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology

(2014) Lori A. Orosco et al.   Nature Communications

Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice

(2014) Wei-Qun Fang et al.   Cell Reports

Autism Spectrum Disorder Genetics

(2014) Michael E. Talkowski et al.   HARVARD REVIEW OF PSYCHIATRY

A Model for the Epigenetic Switch Linking Inflammation to Cell Transformation: Deterministic and Stochastic Approaches

(2014) Claude Gérard et al.   PLoS Computational Biology

GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation

(2014) Meghan Morgan-Smith et al.   eLife

Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy

(2014) J C Naviaux et al.   Translational Psychiatry

Maternal Inflammation Contributes to Brain Overgrowth and Autism-Associated Behaviors through Altered Redox Signaling in Stem and Progenitor Cells

(2014) Janel E. Le Belle et al.   Stem Cell Reports

Early brain enlargement and elevated extra-axial fluid in infants who develop autism spectrum disorder

(2013) Mark D. Shen et al.   BRAIN

Epigenetic changes at gene promoters in response to immune activation in utero

(2013) Bin Tang et al.   BRAIN BEHAVIOR AND IMMUNITY

Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism

(2013) A. Jeremy Willsey et al.   CELL

Integrative Functional Genomic Analyses Implicate Specific Molecular Pathways and Circuits in Autism

(2013) Neelroop N. Parikshak et al.   CELL

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

(2013) Elaine Y. Hsiao et al.   CELL

Elevated maternal C-reactive protein and autism in a national birth cohort

(2013) A S Brown et al.   MOLECULAR PSYCHIATRY

Attention to eyes is present but in decline in 2–6-month-old infants later diagnosed with autism

(2013) Warren Jones et al.   NATURE

Activity-dependent neuronal signalling and autism spectrum disorder

(2013) Daniel H. Ebert et al.   NATURE

AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development

(2013) Jianing Zhang et al.   Neural Development

The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes

(2013) Alicia Subtil-Rodríguez et al.   NUCLEIC ACIDS RESEARCH

Validation of the Modified Checklist for Autism in Toddlers, Revised With Follow-up (M-CHAT-R/F)

(2013) Diana L. Robins et al.   PEDIATRICS

WNT signaling in neuronal maturation and synaptogenesis

(2013) Silvana B. Rosso et al.   Frontiers in Cellular Neuroscience

Focal cortical dysplasias in autism spectrum disorders

(2013) Manuel F Casanova et al.   Acta Neuropathologica Communications

Decreased pyramidal neuron size in Brodmann areas 44 and 45 in patients with autism

(2012) Sarah Jacot-Descombes et al.   ACTA NEUROPATHOLOGICA

Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance

(2012) Edita Aksamitiene et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Maternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response

(2012) Devon B. Oskvig et al.   BRAIN BEHAVIOR AND IMMUNITY

Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism

(2012) Natalia V. Malkova et al.   BRAIN BEHAVIOR AND IMMUNITY

Abnormal microglial–neuronal spatial organization in the dorsolateral prefrontal cortex in autism

(2012) John T. Morgan et al.   BRAIN RESEARCH

ERK Inhibition Rescues Defects in Fate Specification of Nf1-Deficient Neural Progenitors and Brain Abnormalities

(2012) Yuan Wang et al.   CELL

Maternal Immune Activation Increases Neonatal Mouse Cortex Thickness and Cell Density

(2012) Stephen E. P. Smith et al.   Journal of Neuroimmune Pharmacology

Autism-related deficits via dysregulated eIF4E-dependent translational control

(2012) Christos G. Gkogkas et al.   NATURE

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

(2012) Stephan J. Sanders et al.   NATURE

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

De Novo Gene Disruptions in Children on the Autistic Spectrum

(2012) Ivan Iossifov et al.   NEURON

Age-Dependent Brain Gene Expression and Copy Number Anomalies in Autism Suggest Distinct Pathological Processes at Young Versus Mature Ages

(2012) Maggie L. Chow et al.   PLoS Genetics

A review of the evidence for the canonical Wnt pathway in autism spectrum disorders

(2012) Hans Kalkman   Molecular Autism

Development and Evolution of the Human Neocortex

(2011) Jan H. Lui et al.   CELL

Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner

(2011) Janel E. Le Belle et al.   Cell Stem Cell

Neuron Number and Size in Prefrontal Cortex of Children With Autism

(2011) Eric Courchesne et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Wnt Signaling Regulates Neuronal Differentiation of Cortical Intermediate Progenitors

(2011) R. N. Munji et al.   JOURNAL OF NEUROSCIENCE

Prenatal immune challenge compromises the normal course of neurogenesis during development of the mouse cerebral cortex

(2011) Hitomi Soumiya et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Detecting, Studying, and Treating Autism Early: The One-Year Well-Baby Check-Up Approach

(2011) Karen Pierce et al.   JOURNAL OF PEDIATRICS

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations

(2011) Brian J O'Roak et al.   NATURE GENETICS

Maternal infection and immune involvement in autism

(2011) Paul H. Patterson   TRENDS IN MOLECULAR MEDICINE

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

(2011) Ozlem Bozdagi et al.   Molecular Autism

The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes

(2010) Jerzy Wegiel et al.   ACTA NEUROPATHOLOGICA

Preference for Geometric Patterns Early in Life as a Risk Factor for Autism

(2010) Karen Pierce et al.   ARCHIVES OF GENERAL PSYCHIATRY

Association of Hospitalization for Infection in Childhood With Diagnosis of Autism Spectrum Disorders

(2010) Hjördís Ósk Atladóttir et al.   ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE

Abnormal cell patterning at the cortical gray–white matter boundary in autism spectrum disorders

(2010) Thomas A. Avino et al.   BRAIN RESEARCH

von Economo neurons in autism: A stereologic study of the frontoinsular cortex in children

(2010) Micaela Santos et al.   BRAIN RESEARCH

Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease

(2010) Akira Yoshii et al.   Developmental Neurobiology

Longitudinal Magnetic Resonance Imaging Study of Cortical Development through Early Childhood in Autism

(2010) C. M. Schumann et al.   JOURNAL OF NEUROSCIENCE

Neurogenic radial glia in the outer subventricular zone of human neocortex

(2010) David V. Hansen et al.   NATURE

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

(2010) Hsiao-Tuan Chao et al.   NATURE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

A de novo 1p34.2 microdeletion identifies the synaptic vesicle gene RIMS3 as a novel candidate for autism

(2009) R. A. Kumar et al.   JOURNAL OF MEDICAL GENETICS

GSK-3 is a master regulator of neural progenitor homeostasis

(2009) Woo-Yang Kim et al.   NATURE NEUROSCIENCE

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutations

(2009) Jennifer L. Larimore et al.   NEUROBIOLOGY OF DISEASE

Cytokines and CNS Development

(2009) Benjamin E. Deverman et al.   NEURON

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

(2009) Daniela Tropea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune involvement in schizophrenia and autism: Etiology, pathology and animal models

(2008) Paul H. Patterson   BEHAVIOURAL BRAIN RESEARCH

Neurons in the fusiform gyrus are fewer and smaller in autism

(2008) Imke A. J. van Kooten et al.   BRAIN

Making bigger brains-the evolution of neural-progenitor-cell division

(2008) J. L. Fish et al.   JOURNAL OF CELL SCIENCE

Deletion of ERK2 Mitogen-Activated Protein Kinase Identifies Its Key Roles in Cortical Neurogenesis and Cognitive Function

(2008) I. S. Samuels et al.   JOURNAL OF NEUROSCIENCE

Towards a neuroanatomy of autism: A systematic review and meta-analysis of structural magnetic resonance imaging studies

(2007) Andrew C. Stanfield et al.   EUROPEAN PSYCHIATRY