Journal
CELL CYCLE
Volume 11, Issue 10, Pages 1977-1987Publisher
LANDES BIOSCIENCE
DOI: 10.4161/cc.20309
Keywords
glioblastoma; ZFP36; PIM kinases; XIAP; cell death; ripoptosome; tristetraprolin; TTP
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Funding
- Boehringer Ingelheim Fonds
- The Brain Tumour Charity [8/47] Funding Source: researchfish
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RNA binding proteins belonging to the TIS11/TTP gene family regulate the stability of multiple targets. Their inactivation or deregulated expression has recently been related to cancer, and it has been suggested that they are capable of displaying tumor suppressor activities. Here we describe three new targets of ZFP36 (PIM-1, PIM-3 and XIAP) and show by different approaches that its ectopic expression is capable of impairing glioblastoma cell lines viability and invasiveness by interfering with different transduction pathways. Moreover, we provide evidence that compounds capable of inducing the expression of TIS11/TTP genes determine a comparable biological effect on the same cell contexts.
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