Induced PTF1a expression in pancreatic ductal adenocarcinoma cells activates acinar gene networks, reduces tumorigenic properties, and sensitizes cells to gemcitabine treatment

A single transcription factor is sufficient to induce and maintain secretory cell architecture

(2017) Hei-Yong G. Lo et al.   GENES & DEVELOPMENT

Activating transcription factor 3 promotes loss of the acinar cell phenotype in response to cerulein-induced pancreatitis in mice

(2017) Elena N. Fazio et al.   MOLECULAR BIOLOGY OF THE CELL

Acinar cell plasticity and development of pancreatic ductal adenocarcinoma

(2017) Peter Storz   Nature Reviews Gastroenterology & Hepatology

Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis

(2016) C. Benedikt Westphalen et al.   Cell Stem Cell

MIST1 Links Secretion and Stress as both Target and Regulator of the Unfolded Protein Response

(2016) David A. Hess et al.   MOLECULAR AND CELLULAR BIOLOGY

MIST1 and PTF1 Collaborate in Feed-Forward Regulatory Loops That Maintain the Pancreatic Acinar Phenotype in Adult Mice

(2016) Mei Jiang et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A

(2016) Chinh Q. Hoang et al.   MOLECULAR AND CELLULAR BIOLOGY

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions

(2016) Sumiyo Morita et al.   NATURE BIOTECHNOLOGY

Induced pluripotent stem cell technology: a decade of progress

(2016) Yanhong Shi et al.   NATURE REVIEWS DRUG DISCOVERY

The acinar regulator Gata6 suppressesKrasG12V-driven pancreatic tumorigenesis in mice

(2015) Paola Martinelli et al.   GUT

p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells

(2015) J M Bailey et al.   ONCOGENE

The Basic Helix-Loop-Helix Transcription Factor E47 Reprograms Human Pancreatic Cancer Cells to a Quiescent Acinar State With Reduced Tumorigenic Potential

(2015) SangWun Kim et al.   PANCREAS

Rab27A Is Present in Mouse Pancreatic Acinar Cells and Is Required for Digestive Enzyme Secretion

(2015) Yanan Hou et al.   PLoS One

Acinar cell reprogramming: a clinically important target in pancreatic disease

(2015) Christopher L Pin et al.   Epigenomics

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

(2015) Agnieszka K. Witkiewicz et al.   Nature Communications

Overcoming Multidrug Resistance in Cancer Stem Cells

(2015) Karobi Moitra   Biomed Research International

The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma

(2015) Nathan M Krah et al.   eLife

Silencing Mist1 Gene Expression Is Essential for Recovery from Acute Pancreatitis

(2015) Anju Karki et al.   PLoS One

Gemcitabine-Based Chemogene Therapy for Pancreatic Cancer Using Ad-dCK::UMK GDEPT and TS/RR siRNA Strategies

(2015) Soukaina Réjiba et al.   NEOPLASIA

Pancreatic ductal adenocarcinoma cell lines display a plastic ability to bi-directionally convert into cancer stem cells

(2014) ELISA DALLA POZZA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Epigenetic Reprogramming in Mist1−/− Mice Predicts the Molecular Response to Cerulein-Induced Pancreatitis

(2014) Rashid Mehmood et al.   PLoS One

KRAS: feeding pancreatic cancer proliferation

(2014) Kirsten L. Bryant et al.   TRENDS IN BIOCHEMICAL SCIENCES

ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours

(2013) M. Luisa Campos et al.   BIOCHEMICAL JOURNAL

MAPK Signaling Is Required for Dedifferentiation of Acinar Cells and Development of Pancreatic Intraepithelial Neoplasia in Mice

(2013) Meredith A. Collins et al.   GASTROENTEROLOGY

Nr5a2heterozygosity sensitises to, and cooperates with, inflammation inKRasG12V-driven pancreatic tumourigenesis

(2013) Marta Flandez et al.   GUT

Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation

(2013) Guido von Figura et al.   GUT

The ubiquitin ligase Mindbomb 1 coordinates gastrointestinal secretory cell maturation

(2013) Benjamin J. Capoccia et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

Induced Mist1 Expression Promotes Remodeling of Mouse Pancreatic Acinar Cells

(2012) Daniel Direnzo et al.   GASTROENTEROLOGY

Expression of cancer stem cell markers in pancreatic intraepithelial neoplasias and pancreatic ductal adenocarcinomas

(2012) SHOKO KURE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

(2012) Meredith A. Collins et al.   JOURNAL OF CLINICAL INVESTIGATION

RNA Profiling and Chromatin Immunoprecipitation-Sequencing Reveal that PTF1a Stabilizes Pancreas Progenitor Identity via the Control of MNX1/HLXB9 and a Network of Other Transcription Factors

(2012) N. Thompson et al.   MOLECULAR AND CELLULAR BIOLOGY

Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia

(2012) G Shi et al.   ONCOGENE

Scaling factors: Transcription factors regulating subcellular domains

(2011) Jason C. Mills et al.   BIOESSAYS

Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism

(2011) J. Ahnfelt-Ronne et al.   DEVELOPMENT

Extensive Pancreas Regeneration Following Acinar-Specific Disruption of Xbp1 in Mice

(2011) David A. Hess et al.   GASTROENTEROLOGY

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Motif Enrichment Analysis: a unified framework and an evaluation on ChIP data

(2010) Robert C McLeay et al.   BMC BIOINFORMATICS

Association of multi-drug resistance gene polymorphisms with pancreatic cancer outcome

(2010) Motofumi Tanaka et al.   CANCER

MIST1 regulates the pancreatic acinar cell expression of Atp2c2, the gene encoding secretory pathway calcium ATPase 2

(2010) Victoria C. Garside et al.   EXPERIMENTAL CELL RESEARCH

ABCG2: A potential marker of stem cells and novel target in stem cell and cancer therapy

(2010) Xi-wei Ding et al.   LIFE SCIENCES

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

Phenotype and Genotype of Pancreatic Cancer Cell Lines

(2010) Emily L. Deer et al.   PANCREAS

Mucins and Pancreatic Cancer

(2010) Nicolas Jonckheere et al.   Cancers

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Loss of the Acinar-Restricted Transcription Factor Mist1 Accelerates Kras-Induced Pancreatic Intraepithelial Neoplasia

(2009) Guanglu Shi et al.   GASTROENTEROLOGY

ABC Transporters, Drug Resistance, and Cancer Stem Cells

(2009) Michael Dean   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

RAB26 and RAB3D Are Direct Transcriptional Targets of MIST1 That Regulate Exocrine Granule Maturation

(2009) X. Tian et al.   MOLECULAR AND CELLULAR BIOLOGY

Characterizing DNA methylation patterns in pancreatic cancer genome

(2009) Aik Choon Tan et al.   Molecular Oncology

Acute pancreatitis: Etiology and common pathogenesis

(2009) Guo-Jun Wang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Mist1 Regulates Pancreatic Acinar Cell Proliferation Through p21CIP1/WAF1

(2008) Di Jia et al.   GASTROENTEROLOGY

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice

(2008) N. Habbe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA