Is Glioblastoma an Epigenetic Malignancy?

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas

(2015) Yuchen Jiao et al.   Oncotarget

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma

(2015) Kasthuri Kannan et al.   Oncotarget

A microarray-based DNA methylation study of glioblastoma multiforme

(2014) Ramon Martinez et al.   Epigenetics

Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism

(2013) Ya-Luen Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chromatin Remodeling Defects in Pediatric and Young Adult Glioblastoma: A Tale of a Variant Histone 3 Tail

(2013) Adam M. Fontebasso et al.   BRAIN PATHOLOGY

SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma

(2013) Eric Letouzé et al.   CANCER CELL

Chromatin Regulator PRC2 Is a Key Regulator of Epigenetic Plasticity in Glioblastoma

(2013) A. Natsume et al.   CANCER RESEARCH

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

Targeting histone modifications—epigenetics in cancer

(2013) Tanja Waldmann et al.   CURRENT OPINION IN CELL BIOLOGY

Histone 3 Lysine 9 Trimethylation Is Differentially Associated With Isocitrate Dehydrogenase Mutations in Oligodendrogliomas and High-Grade Astrocytomas

(2013) Sriram Venneti et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

DNA methylation dynamics in health and disease

(2013) Yehudit Bergman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma

(2013) P. W. Lewis et al.   SCIENCE

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Molecular pathogenesis of IDH mutations in gliomas

(2012) Koichi Ichimura   Brain Tumor Pathology

Valproic acid for the treatment of malignant gliomas: review of the preclinical rationale and published clinical results

(2012) Sharon Berendsen et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

IDH mutations in acute myeloid leukemia

(2012) Dinesh Rakheja et al.   HUMAN PATHOLOGY

Targeting the enhancer of zeste homologue 2 in medulloblastoma

(2012) Irina Alimova et al.   INTERNATIONAL JOURNAL OF CANCER

The Capicua repressor - a general sensor of RTK signaling in development and disease

(2012) G. Jimenez et al.   JOURNAL OF CELL SCIENCE

P53-dependent antiproliferative and pro-apoptotic effects of trichostatin A (TSA) in glioblastoma cells

(2012) K. Bajbouj et al.   JOURNAL OF NEURO-ONCOLOGY

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

(2012) Gang Wu et al.   NATURE GENETICS

Targeting Epigenetic Readers in Cancer

(2012) Mark A. Dawson et al.   NEW ENGLAND JOURNAL OF MEDICINE

DNMT (DNA methyltransferase) inhibitors radiosensitize human cancer cells by suppressing DNA repair activity

(2012) Hak Jae Kim et al.   Radiation Oncology

Genetically-defined metabolic reprogramming in cancer

(2012) Andrew R. Mullen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A focus on the preclinical development and clinical status of the histone deacetylase inhibitor, romidepsin (depsipeptide, Istodax®)

(2012) Simon J Harrison et al.   Epigenomics

p53 in trichostatin A induced C6 glioma cell death

(2011) Ya-Fen Hsu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

DNA Hypermethylation and Histone Modifications Downregulate the Candidate Tumor Suppressor Gene RRP22 on 22q12 in Human Gliomas

(2011) Natalie Schmidt et al.   BRAIN PATHOLOGY

POTEH hypomethylation, a new epigenetic biomarker for glioma prognosis

(2011) Xiaoping Liu et al.   BRAIN RESEARCH

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

A Developmental Taxonomy of Glioblastoma Defined and Maintained by MicroRNAs

(2011) T.-M. Kim et al.   CANCER RESEARCH

Significance of IDH mutations varies with tumor histology, grade, and genetics in Japanese glioma patients

(2011) Akitake Mukasa et al.   CANCER SCIENCE

Readers of histone modifications

(2011) Miyong Yun et al.   CELL RESEARCH

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

The Promoter Hypermethylation Status of GATA6, MGMT, and FHIT in Glioblastoma

(2011) Gulsah Cecener et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Epigenetic-Based Therapies in Cancer

(2011) Sang-Hyun Song et al.   DRUGS

DNMT3B gene amplification predicts resistance to DNA demethylating drugs

(2011) Laia Simó-Riudalbas et al.   GENES CHROMOSOMES & CANCER

HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications

(2011) Omar Khan et al.   IMMUNOLOGY AND CELL BIOLOGY

Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma From a Distinct Cell of Origin

(2011) Albert Lai et al.   JOURNAL OF CLINICAL ONCOLOGY

Epigenetic regulation of DNA methyltransferases: DNMT1 and DNMT3B in gliomas

(2011) Ganeshkumar Rajendran et al.   JOURNAL OF NEURO-ONCOLOGY

Landscape of TET2 mutations in acute myeloid leukemia

(2011) S Weissmann et al.   LEUKEMIA

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

(2011) Ryan D. Morin et al.   NATURE

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

(2011) Xiao-Jing Yan et al.   NATURE GENETICS

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Quantitative Characterization of the Interactions amongc-mycTranscriptional Regulators FUSE, FBP, and FIR

(2010) Hsin-hao Hsiao et al.   BIOCHEMISTRY

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Global Histone Modification Patterns as Prognostic Markers to Classify Glioma Patients

(2010) B.-l. Liu et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Current and Emerging Treatment Strategies for Cutaneous T-cell Lymphoma

(2010) Frederick Lansigan et al.   DRUGS

Isocitrate dehydrogenase-1 mutations: a fundamentally new understanding of diffuse glioma?

(2010) Nanne K Kloosterhof et al.   LANCET ONCOLOGY

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

(2010) Gorica Nikoloski et al.   NATURE GENETICS

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

(2010) Thomas Ernst et al.   NATURE GENETICS

Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells

(2010) F. Orzan et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas

(2009) Christian Hartmann et al.   ACTA NEUROPATHOLOGICA

Antitumor Effects of a Combined 5-Aza-2'Deoxycytidine and Valproic Acid Treatment on Rhabdomyosarcoma and Medulloblastoma in Ptch Mutant Mice

(2009) I. Ecke et al.   CANCER RESEARCH

EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance

(2009) M.-L. Suva et al.   CANCER RESEARCH

Unsupervised Analysis of Transcriptomic Profiles Reveals Six Glioma Subtypes

(2009) A. Li et al.   CANCER RESEARCH

IDH1mutations at residue p.R132 (IDH1R132) occur frequently in high-grade gliomas but not in other solid tumors

(2009) Fonnet E. Bleeker et al.   HUMAN MUTATION

HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity

(2009) Vivek Sharma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Trichostatin A Stimulates Steroid 5α-Reductase Gene Expression in Rat C6 Glioma Cells via a Mechanism Involving Sp1 and Sp3 Transcription Factors

(2009) Song Her et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors

(2009) Hemant Sarin   Journal of Translational Medicine

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS

Mutation inTET2in Myeloid Cancers

(2009) François Delhommeau et al.   NEW ENGLAND JOURNAL OF MEDICINE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

GSK3β Regulates Differentiation and Growth Arrest in Glioblastoma

(2009) Serdar Korur et al.   PLoS One

Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma

(2009) M. Berdasco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Analysis of the IDH1 codon 132 mutation in brain tumors

(2008) Jörg Balss et al.   ACTA NEUROPATHOLOGICA

Copy number alterations of the polycomb gene BMI1 in gliomas

(2008) Valtteri Häyry et al.   ACTA NEUROPATHOLOGICA

Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas

(2008) Agda KB Lucio-Eterovic et al.   BMC CANCER

Epigenetic-Mediated Dysfunction of the Bone Morphogenetic Protein Pathway Inhibits Differentiation of Glioblastoma-Initiating Cells

(2008) Jeongwu Lee et al.   CANCER CELL

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

Loss of NECL1, a novel tumor suppressor, can be restored in glioma by HDAC inhibitor-Trichostatin A through Sp1 binding site

(2008) Jing Gao et al.   GLIA

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE