Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics

Intra- and interregional coregulation of opioid genes: broken symmetry in spinal circuits

(2017) Olga Kononenko et al.   FASEB JOURNAL

Pathway- and Cell-Specific Kappa-Opioid Receptor Modulation of Excitation-Inhibition Balance Differentially Gates D1 and D2 Accumbens Neuron Activity

(2017) Hugo A. Tejeda et al.   NEURON

Antireward, compulsivity, and addiction: seminal contributions of Dr. Athina Markou to motivational dysregulation in addiction

(2017) George F. Koob   PSYCHOPHARMACOLOGY

Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels

(2016) Steve Horvath et al.   Aging-US

Impact of the Innate Immune Response in the Actions of Ethanol on the Central Nervous System

(2016) Jorge Montesinos et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Low μ-Opioid Receptor Status in Alcohol Dependence Identified by Combined Positron Emission Tomography and Post-Mortem Brain Analysis

(2016) Derik Hermann et al.   NEUROPSYCHOPHARMACOLOGY

The neuroimmune transcriptome and alcohol dependence: potential for targeted therapies

(2016) Anna Warden et al.   PHARMACOGENOMICS

Convergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protracted abstinence

(2016) Natalie Hirth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease

(2016) Corey T. Watson et al.   Genome Medicine

Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23

(2015) Cleo J. L. M. Smeets et al.   BRAIN

The Brain on Drugs: From Reward to Addiction

(2015) Nora D. Volkow et al.   CELL

Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward

(2015) Ream Al-Hasani et al.   NEURON

Sufficiency of Mesolimbic Dopamine Neuron Stimulation for the Progression to Addiction

(2015) Vincent Pascoli et al.   NEURON

A survey of human brain transcriptome diversity at the single cell level

(2015) Spyros Darmanis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refining deep brain stimulation to emulate optogenetic treatment of synaptic pathology

(2015) M. Creed et al.   SCIENCE

Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics

(2015) Daniil Sarkisyan et al.   Frontiers in Cellular Neuroscience

Kappa-Opioid Receptor Antagonism: A Mechanism for Treatment of Relief Drinking?

(2014) Markus Heilig et al.   BIOLOGICAL PSYCHIATRY

Contrasting forms of cocaine-evoked plasticity control components of relapse

(2014) Vincent Pascoli et al.   NATURE

Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn

(2014) Rita Bardoni et al.   NEURON

Aversive behavior induced by optogenetic inactivation of ventral tegmental area dopamine neurons is mediated by dopamine D2 receptors in the nucleus accumbens

(2014) T. Danjo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A systems medicine research approach for studying alcohol addiction

(2013) Rainer Spanagel et al.   ADDICTION BIOLOGY

The One-Two Punch of Alcoholism: Role of Central Amygdala Dynorphins/Kappa-Opioid Receptors

(2013) Jessica L. Kissler et al.   BIOLOGICAL PSYCHIATRY

A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression

(2013) Jerry Guintivano et al.   Epigenetics

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

(2013) Yi-an Chen et al.   Epigenetics

Long-Term Antagonism of   Opioid Receptors Prevents Escalation of and Increased Motivation for Heroin Intake

(2013) J. E. Schlosburg et al.   JOURNAL OF NEUROSCIENCE

Addiction is a Reward Deficit and Stress Surfeit Disorder

(2013) George F. Koob   Frontiers in Psychiatry

The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety

(2012) Jesse R. Schank et al.   ADDICTION BIOLOGY

Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics

(2012) Mary Jeanne Kreek et al.   JOURNAL OF CLINICAL INVESTIGATION

κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction

(2012) Eduardo R. Butelman et al.   TRENDS IN NEUROSCIENCES

Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system

(2012) Sunil Sirohi et al.   Frontiers in Molecular Neuroscience

The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction

(2011) Igor Bazov et al.   ADDICTION BIOLOGY

Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications

(2011) Rita Z. Goldstein et al.   NATURE REVIEWS NEUROSCIENCE

κ-opioid receptors are implicated in the increased potency of intra-accumbens nalmefene in ethanol-dependent rats

(2011) Kathryn A. Nealey et al.   NEUROPHARMACOLOGY

Regional mRNA expression of the endogenous opioid and dopaminergic systems in brains of C57BL/6J and 129P3/J mice: Strain and heroin effects

(2011) S.D. Schlussman et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The Striatal Balancing Act in Drug Addiction: Distinct Roles of Direct and Indirect Pathway Medium Spiny Neurons

(2011) Mary Kay Lobo et al.   Frontiers in Neuroanatomy

Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats

(2010) Brendan M. Walker et al.   ADDICTION BIOLOGY

Distinct Roles of Synaptic Transmission in Direct and Indirect Striatal Pathways to Reward and Aversive Behavior

(2010) Takatoshi Hikida et al.   NEURON

The role of the dynorphin–κ opioid system in the reinforcing effects of drugs of abuse

(2010) Sunmee Wee et al.   PSYCHOPHARMACOLOGY

Physiology and Pharmacology of Striatal Neurons

(2009) Anatol C. Kreitzer   Annual Review of Neuroscience

Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders

(2009) Jürgen Rehm et al.   LANCET

Neurocircuitry of Addiction

(2009) George F Koob et al.   NEUROPSYCHOPHARMACOLOGY

Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine

(2009) Sunmee Wee et al.   PSYCHOPHARMACOLOGY

Chronic ethanol exposure leads to divergent control of dopaminergic synapses in distinct target regions

(2008) Julie C. Healey et al.   ALCOHOL

An Australian Brain Bank: a critical investment with a high return!

(2008) D. Sheedy et al.   CELL AND TISSUE BANKING

Striatal and ventral pallidum dynorphin concentrations are markedly increased in human chronic cocaine users

(2008) Paul S. Frankel et al.   NEUROPHARMACOLOGY

A Functional Haplotype Implicated in Vulnerability to Develop Cocaine Dependence is Associated with Reduced PDYN Expression in Human Brain

(2008) Vadim Yuferov et al.   NEUROPSYCHOPHARMACOLOGY