Proteolytic Degradation of Hippocampal STEP61 in LTP and Learning

The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline

(2018) David Castonguay et al.   CURRENT BIOLOGY

Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: Regulation by BDNF

(2018) Silvia Cases et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Oleanolic acid ameliorates cognitive dysfunction caused by cholinergic blockade via TrkB-dependent BDNF signaling

(2017) Se Jin Jeon et al.   NEUROPHARMACOLOGY

Striatal-enriched phosphatase 61 inhibited the nociceptive plasticity in spinal cord dorsal horn of rats

(2017) Zhan-Wei Suo et al.   NEUROSCIENCE

A calpain-2 selective inhibitor enhances learning & memory by prolonging ERK activation

(2016) Yan Liu et al.   NEUROPHARMACOLOGY

Striatal-enriched protein tyrosine phosphatase modulates nociception

(2016) Garikoitz Azkona et al.   PAIN

Calpain-1 and Calpain-2: The Yin and Yang of Synaptic Plasticity and Neurodegeneration

(2016) Michel Baudry et al.   TRENDS IN NEUROSCIENCES

Multiple cellular cascades participate in long-term potentiation and in hippocampus-dependent learning

(2015) Michel Baudry et al.   BRAIN RESEARCH

TrkB blockade in the hippocampus after training or retrieval impairs memory: protection from consolidation impairment by histone deacetylase inhibition

(2015) Martina Blank et al.   JOURNAL OF NEURAL TRANSMISSION

Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61) levels

(2015) Jian Xu et al.   JOURNAL OF NEUROCHEMISTRY

Different Patterns of Electrical Activity Lead to Long-term Potentiation by Activating Different Intracellular Pathways

(2015) G. Zhu et al.   JOURNAL OF NEUROSCIENCE

BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome

(2015) Ana Saavedra et al.   MOLECULAR NEUROBIOLOGY

The Role of Proteases in Hippocampal Synaptic Plasticity: Putting Together Small Pieces of a Complex Puzzle

(2015) Ivan L. Salazar et al.   NEUROCHEMICAL RESEARCH

Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity

(2015) Sung-Soo Jang et al.   Molecular Brain

Ubiquitin proteasome system-mediated degradation of synaptic proteins: An update from the postsynaptic side

(2014) Nien-Pei Tsai   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of Tyrosine Phosphatase STEP61 by Protein Kinase A during Motor Skill Learning in Mice

(2014) Laure Chagniel et al.   PLoS One

A molecular brake controls the magnitude of long-term potentiation

(2014) Yubin Wang et al.   Nature Communications

Inhibitor of the Tyrosine Phosphatase STEP Reverses Cognitive Deficits in a Mouse Model of Alzheimer's Disease

(2014) Jian Xu et al.   PLOS BIOLOGY

The ubiquitin–proteasome system as a critical regulator of synaptic plasticity and long-term memory formation

(2013) Timothy J. Jarome et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Control of Synaptic Plasticity and Memory via Suppression of Poly(A)-Binding Protein

(2013) Arkady Khoutorsky et al.   NEURON

Regulation of Hippocampal cGMP Levels as a Candidate to Treat Cognitive Deficits in Huntington’s Disease

(2013) Ana Saavedra et al.   PLoS One

A Critical Role for Protein Tyrosine Phosphatase Nonreceptor Type 5 in Determining Individual Susceptibility to Develop Stress-Related Cognitive and Morphological Changes

(2012) C.-H. Yang et al.   JOURNAL OF NEUROSCIENCE

The tyrosine phosphatase STEP constrains amygdala-dependent memory formation and neuroplasticity

(2012) P. Olausson et al.   NEUROSCIENCE

Dephosphorylation of specific sites in the kinase-specificity sequence domain leads to ubiquitin-mediated degradation of the tyrosine phosphatase STEP

(2011) Saibal Mukherjee et al.   BIOCHEMICAL JOURNAL

Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease

(2011) Albert Giralt et al.   HUMAN MOLECULAR GENETICS

Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice

(2011) Maxime Cazorla et al.   JOURNAL OF CLINICAL INVESTIGATION

Striatal-Enriched Protein Tyrosine Phosphatase Expression and Activity in Huntington's Disease: A STEP in the Resistance to Excitotoxicity

(2011) A. Saavedra et al.   JOURNAL OF NEUROSCIENCE

GABAA Receptor Blockade Enhances Memory Consolidation by Increasing Hippocampal BDNF Levels

(2011) Dong Hyun Kim et al.   NEUROPSYCHOPHARMACOLOGY

Neurodevelopmental Disruption of Cortico-Striatal Function Caused by Degeneration of Habenula Neurons

(2011) Young-A Lee et al.   PLoS One

Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase

(2011) T. R. Hicklin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitination in Postsynaptic Function and Plasticity

(2010) Angela M. Mabb et al.   Annual Review of Cell and Developmental Biology

NR2B-NMDA receptor-mediated increases in intracellular Ca2+ concentration regulate the tyrosine phosphatase, STEP, and ERK MAP kinase signaling

(2010) Surojit Paul et al.   JOURNAL OF NEUROCHEMISTRY

The ubiquitin-proteasome pathway and synaptic plasticity

(2010) A. N. Hegde   LEARNING & MEMORY

The biochemistry of memory: The 26year journey of a ‘new and specific hypothesis’

(2010) Michel Baudry et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Ketamine impairs recognition memory consolidation and prevents learning-induced increase in hippocampal brain-derived neurotrophic factor levels

(2010) B.K. Goulart et al.   NEUROSCIENCE

Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model

(2010) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal Sensitivity of Protein Kinase A Activation in Late-Phase Long Term Potentiation

(2010) MyungSook Kim et al.   PLoS Computational Biology

Stimulus pattern dependence of the Alzheimer's disease amyloid-β 42 peptide's inhibition of long term potentiation in mouse hippocampal slices

(2009) Jeffrey P. Smith et al.   BRAIN RESEARCH

Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP

(2009) J. Xu et al.   JOURNAL OF NEUROSCIENCE

A Coordinated Local Translational Control Point at the Synapse Involving Relief from Silencing and MOV10 Degradation

(2009) Sourav Banerjee et al.   NEURON

A Substrate Trapping Mutant Form of Striatal-Enriched Protein Tyrosine Phosphatase Prevents Amphetamine-Induced Stereotypies and Long-Term Potentiation in the Striatum

(2008) Roman Tashev et al.   BIOLOGICAL PSYCHIATRY

Protein degradation, as with protein synthesis, is required during not only long-term spatial memory consolidation but also reconsolidation

(2008) Julien Artinian et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Tyrosine Phosphatase STEP Mediates AMPA Receptor Endocytosis after Metabotropic Glutamate Receptor Stimulation

(2008) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Proteasome inhibition enhances the induction and impairs the maintenance of late-phase long-term potentiation

(2008) C. Dong et al.   LEARNING & MEMORY

Knockout of STriatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation

(2008) Deepa V. Venkitaramani et al.   SYNAPSE