The Role of Proteases in Hippocampal Synaptic Plasticity: Putting Together Small Pieces of a Complex Puzzle

Regulation of hippocampal synaptic plasticity by BDNF

(2015) Graciano Leal et al.   BRAIN RESEARCH

An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A

(2015) Jason J. Yi et al.   CELL

The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking

(2015) Yuda Huo et al.   JOURNAL OF NEUROCHEMISTRY

PKM , But Not PKC , Is Rapidly Synthesized and Degraded at the Neuronal Synapse

(2015) S. F. Palida et al.   JOURNAL OF NEUROSCIENCE

Different Patterns of Electrical Activity Lead to Long-term Potentiation by Activating Different Intracellular Pathways

(2015) G. Zhu et al.   JOURNAL OF NEUROSCIENCE

Caspase-3 Deficiency Results in Disrupted Synaptic Homeostasis and Impaired Attention Control

(2015) S.-C. Lo et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Rapid Local RhoA Synthesis Is Required for Hippocampal Synaptic Plasticity

(2015) V. Briz et al.   JOURNAL OF NEUROSCIENCE

Differential Role of the Proteasome in the Early and Late Phases of BDNF-Induced Facilitation of LTP

(2015) A. R. Santos et al.   JOURNAL OF NEUROSCIENCE

Loss of F-box Only Protein 2 (Fbxo2) Disrupts Levels and Localization of Select NMDA Receptor Subunits, and Promotes Aberrant Synaptic Connectivity

(2015) Graham Atkin et al.   JOURNAL OF NEUROSCIENCE

GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome

(2015) J. S. Ferreira et al.   JOURNAL OF NEUROSCIENCE

Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update

(2015) Shane O’Sullivan et al.   MEDIATORS OF INFLAMMATION

Quantifying Ubiquitin Signaling

(2015) Alban Ordureau et al.   MOLECULAR CELL

A Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain

(2015) Ju Huang et al.   NEURON

The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3

(2015) Luana Fioriti et al.   NEURON

RING finger protein 121 facilitates the degradation and membrane localization of voltage-gated sodium channels

(2015) Kazutoyo Ogino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A molecular census of 26S proteasomes in intact neurons

(2015) S. Asano et al.   SCIENCE

Crystal Structure of the Human 20S Proteasome in Complex with Carfilzomib

(2015) Wayne Harshbarger et al.   STRUCTURE

Reconsolidation and the regulation of plasticity: moving beyond memory

(2015) Robert P. Bonin et al.   TRENDS IN NEUROSCIENCES

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core

(2015) Paula C.A. da Fonseca et al.   Nature Communications

Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species

(2015) Yamunadevi Subburaj et al.   Nature Communications

UBE3A Regulates Synaptic Plasticity and Learning and Memory by Controlling SK2 Channel Endocytosis

(2015) Jiandong Sun et al.   Cell Reports

Activity-Dependent Ubiquitination of GluA1 and GluA2 Regulates AMPA Receptor Intracellular Sorting and Degradation

(2015) Jocelyn Widagdo et al.   Cell Reports

Coordination between Translation and Degradation Regulates Inducibility of mGluR-LTD

(2015) Matthew E. Klein et al.   Cell Reports

Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis

(2015) Jun Hamazaki et al.   PLoS Genetics

Prion-like Mechanism in Amyotrophic Lateral Sclerosis: are Protein Aggregates the Key?

(2015) Shynrye Lee et al.   Experimental Neurobiology

Early enriched environment induces an increased conversion of proBDNF to BDNF in the adult rat's hippocampus

(2014) Wenyu Cao et al.   BEHAVIOURAL BRAIN RESEARCH

Endocytic Adaptor Epidermal Growth Factor Receptor Substrate 15 (Eps15) Is Involved in the Trafficking of Ubiquitinated α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptors

(2014) Amy Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic Strength Is Bidirectionally Controlled by Opposing Activity-Dependent Regulation of Nedd4-1 and USP8

(2014) S. L. Scudder et al.   JOURNAL OF NEUROSCIENCE

Proteasome Modulates Positive and Negative Translational Regulators in Long-Term Synaptic Plasticity

(2014) C. Dong et al.   JOURNAL OF NEUROSCIENCE

Genetic Removal of Matrix Metalloproteinase 9 Rescues the Symptoms of Fragile X Syndrome in a Mouse Model

(2014) H. Sidhu et al.   JOURNAL OF NEUROSCIENCE

Local Pruning of Dendrites and Spines by Caspase-3-Dependent and Proteasome-Limited Mechanisms

(2014) A. Erturk et al.   JOURNAL OF NEUROSCIENCE

Cytokine-Induced GAPDH Sulfhydration Affects PSD95 Degradation and Memory

(2014) Sajad Mir et al.   MOLECULAR CELL

Engineering a memory with LTD and LTP

(2014) Sadegh Nabavi et al.   NATURE

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Triad3A Regulates Synaptic Strength by Ubiquitination of Arc

(2014) Angela M. Mabb et al.   NEURON

Proteasome regulates the mediators of cytoplasmic polyadenylation signaling during late-phase long-term potentiation

(2014) Chenghai Dong et al.   NEUROSCIENCE LETTERS

Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth

(2014) H.-E. Hsia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus

(2014) Jianmin Yang et al.   Cell Reports

Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes

(2014) Christos G. Gkogkas et al.   Cell Reports

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Local ubiquitin-proteasome-mediated proteolysis and long-term synaptic plasticity

(2014) Ashok N. Hegde et al.   Frontiers in Molecular Neuroscience

Mechanisms of Generating Polyubiquitin Chains of Different Topology

(2014) Randy Suryadinata et al.   Cells

High MMP-9 activity levels in fragile X syndrome are lowered by minocycline

(2013) Magdalena Dziembowska et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Negative Regulation of 26S Proteasome Stability via Calpain-mediated Cleavage of Rpn10 Subunit upon Mitochondrial Dysfunction in Neurons

(2013) Qian Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early postnatal expression and localization of matrix metalloproteinases-2 and -9 during establishment of rat hippocampal synaptic circuitry

(2013) Paven K. Aujla et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Calpain-2-Mediated PTEN Degradation Contributes to BDNF-Induced Stimulation of Dendritic Protein Synthesis

(2013) V. Briz et al.   JOURNAL OF NEUROSCIENCE

The Fragile X Mental Retardation Protein Regulates Matrix Metalloproteinase 9 mRNA at Synapses

(2013) A. Janusz et al.   JOURNAL OF NEUROSCIENCE

Distinct Roles for  -Calpain and m-Calpain in Synaptic NMDAR-Mediated Neuroprotection and Extrasynaptic NMDAR-Mediated Neurodegeneration

(2013) Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Conditional Disruption of Calpain in the CNS Alters Dendrite Morphology, Impairs LTP, and Promotes Neuronal Survival following Injury

(2013) M. Amini et al.   JOURNAL OF NEUROSCIENCE

Electrocortical changes associated with minocycline treatment in fragile X syndrome

(2013) Andrea Schneider et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Control of Synaptic Plasticity and Memory via Suppression of Poly(A)-Binding Protein

(2013) Arkady Khoutorsky et al.   NEURON

Regulation of Axon Degeneration after Injury and in Development by the Endogenous Calpain Inhibitor Calpastatin

(2013) Jing Yang et al.   NEURON

BDNF-induced local protein synthesis and synaptic plasticity

(2013) Graciano Leal et al.   NEUROPHARMACOLOGY

Amyloid-β25–35 induces impairment of cognitive function and long-term potentiation through phosphorylation of collapsin response mediator protein 2

(2013) Toshinari Isono et al.   NEUROSCIENCE RESEARCH

Matrix Metalloproteinases Regulate the Formation of Dendritic Spine Head Protrusions during Chemically Induced Long-Term Potentiation

(2013) Zsuzsanna Szepesi et al.   PLoS One

Matrix metalloproteinase-2 and -9 as promising benefactors in development, plasticity and repair of the nervous system

(2013) Mieke Verslegers et al.   PROGRESS IN NEUROBIOLOGY

Role of the ubiquitin–proteasome system in brain ischemia: Friend or foe?

(2013) Margarida V. Caldeira et al.   PROGRESS IN NEUROBIOLOGY

LabCaS: Labeling calpain substrate cleavage sites from amino acid sequence using conditional random fields

(2013) Yong-Xian Fan et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Caspase Functions in Cell Death and Disease

(2013) D. R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

Involvement of TrkB- and p75NTR-signaling pathways in two contrasting forms of long-lasting synaptic plasticity

(2013) Shigeo Sakuragi et al.   Scientific Reports

The Ubiquitin Receptor S5a/Rpn10 Links Centrosomal Proteasomes with Dendrite Development in the Mammalian Brain

(2013) Sidharth V. Puram et al.   Cell Reports

Multiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95

(2012) Nien-Pei Tsai et al.   CELL

Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells

(2012) Shuchen Gu et al.   CELLULAR SIGNALLING

Synaptic cell adhesion molecule-2 and collapsin response mediator protein-2 are novel members of the matrix metalloproteinase-9 degradome

(2012) Malgorzata Bajor et al.   JOURNAL OF NEUROCHEMISTRY

GluN2D Subunit-Containing NMDA Receptors Control Tissue Plasminogen Activator-Mediated Spatial Memory

(2012) P. Obiang et al.   JOURNAL OF NEUROSCIENCE

Integrin Dynamics Produce a Delayed Stage of Long-Term Potentiation and Memory Consolidation

(2012) A. H. Babayan et al.   JOURNAL OF NEUROSCIENCE

Evidence for a Fragile X Mental Retardation Protein-Mediated Translational Switch in Metabotropic Glutamate Receptor-Triggered Arc Translation and Long-Term Depression

(2012) F. Niere et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of Rpt6 Regulates Synaptic Strength in Hippocampal Neurons

(2012) S. N. Djakovic et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Local Translation of Matrix Metalloproteinase-9

(2012) M. Dziembowska et al.   JOURNAL OF NEUROSCIENCE

Dephosphorylation-Induced Ubiquitination and Degradation of FMRP in Dendrites: A Role in Immediate Early mGluR-Stimulated Translation

(2012) V. C. Nalavadi et al.   JOURNAL OF NEUROSCIENCE

Synaptic Protein Ubiquitination in Rat Brain Revealed by Antibody-based Ubiquitome Analysis

(2012) Chan Hyun Na et al.   JOURNAL OF PROTEOME RESEARCH

Long term potentiation affects intracellular metalloproteinases activity in the mossy fiber — CA3 pathway

(2012) Grzegorz Wiera et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Molecular Model of the Human 26S Proteasome

(2012) Paula C.A. da Fonseca et al.   MOLECULAR CELL

GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling

(2012) Seung Min Shin et al.   NATURE NEUROSCIENCE

Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology

(2012) Bradley T. Hyman et al.   NATURE REVIEWS NEUROSCIENCE

Activity-Dependent Growth of New Dendritic Spines Is Regulated by the Proteasome

(2012) Andrew M. Hamilton et al.   NEURON

Transsynaptic Signaling by Activity-Dependent Cleavage of Neuroligin-1

(2012) Rui T. Peixoto et al.   NEURON

The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging

(2012) Iván J. Cajigas et al.   NEURON

Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission

(2012) M. P. Lussier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ubiquitin proteasome system in neurodegenerative diseases: Culprit, accomplice or victim?

(2012) F.J.A. Dennissen et al.   PROGRESS IN NEUROBIOLOGY

Serine proteases, serine protease inhibitors, and protease-activated receptors: Roles in synaptic function and behavior

(2011) Antoine G. Almonte et al.   BRAIN RESEARCH

Neuralized1 Activates CPEB3: A Function for Nonproteolytic Ubiquitin in Synaptic Plasticity and Memory Storage

(2011) Elias Pavlopoulos et al.   CELL

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

Impact of genetic insights into calpain biology

(2011) Hiroyuki Sorimachi et al.   JOURNAL OF BIOCHEMISTRY

Influence of matrix metalloproteinase MMP-9 on dendritic spine morphology

(2011) P. Michaluk et al.   JOURNAL OF CELL SCIENCE

Neuropsin—A possible modulator of synaptic plasticity

(2011) Sadao Shiosaka et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking

(2011) Amy Lin et al.   JOURNAL OF NEUROCHEMISTRY

Enhanced neuronal plasticity and elevated endogenous sAPPα levels in mice over-expressing MMP9

(2011) Apostolia Fragkouli et al.   JOURNAL OF NEUROCHEMISTRY

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Ubiquitination of the AMPA Receptor Subunit GluA2

(2011) M. P. Lussier et al.   JOURNAL OF NEUROSCIENCE

Reversible Inhibition of PSD-95 mRNA Translation by miR-125a, FMRP Phosphorylation, and mGluR Signaling

(2011) Ravi S. Muddashetty et al.   MOLECULAR CELL

Neuropsin cleaves EphB2 in the amygdala to control anxiety

(2011) Benjamin K. Attwood et al.   NATURE

Nonapoptotic Function of BAD and BAX in Long-Term Depression of Synaptic Transmission

(2011) Song Jiao et al.   NEURON

Homeostatic Regulation of AMPA Receptor Trafficking and Degradation by Light-Controlled Single-Synaptic Activation

(2011) Qingming Hou et al.   NEURON

Experience-Dependent Plasticity and Modulation of Growth Regulatory Molecules at Central Synapses

(2011) Simona Foscarin et al.   PLoS One

Calpain Cleavage Prediction Using Multiple Kernel Learning

(2011) David A. duVerle et al.   PLoS One

GPS-CCD: A Novel Computational Program for the Prediction of Calpain Cleavage Sites

(2011) Zexian Liu et al.   PLoS One

Polyglutamine diseases: The special case of ataxin-3 and Machado–Joseph disease

(2011) Carlos A. Matos et al.   PROGRESS IN NEUROBIOLOGY

Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

(2010) Zheng Li et al.   CELL

The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc

(2010) Paul L. Greer et al.   CELL

Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines

(2010) Baris Bingol et al.   CELL

Brain-Derived Neurotrophic Factor and Epidermal Growth Factor Activate Neuronal m-Calpain via Mitogen-Activated Protein Kinase-Dependent Phosphorylation

(2010) S. Zadran et al.   JOURNAL OF NEUROSCIENCE

Ubiquitination Acutely Regulates Presynaptic Neurotransmitter Release in Mammalian Neurons

(2010) G. V. Rinetti et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Ubiquitination of GluA1 Mediates a Distinct AMPA Receptor Endocytosis and Sorting Pathway

(2010) L. A. Schwarz et al.   JOURNAL OF NEUROSCIENCE

Working on a chain: E3s ganging up for ubiquitylation

(2010) Meredith B. Metzger et al.   NATURE CELL BIOLOGY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

How does PKMζ maintain long-term memory?

(2010) Todd C. Sacktor   NATURE REVIEWS NEUROSCIENCE

Long-term depression in the CNS

(2010) Graham L. Collingridge et al.   NATURE REVIEWS NEUROSCIENCE

An essential postsynaptic role for the ubiquitin proteasome system in slow homeostatic synaptic plasticity in cultured hippocampal neurons

(2010) S.K. Jakawich et al.   NEUROSCIENCE

Degradation of Postsynaptic Scaffold GKAP and Regulation of Dendritic Spine Morphology by the TRIM3 Ubiquitin Ligase in Rat Hippocampal Neurons

(2010) Albert Y. Hung et al.   PLoS One

Hippocampal long-term depression is required for the consolidation of spatial memory

(2010) Y. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coincident Pre- and Postsynaptic Activation Induces Dendritic Filopodia via Neurotrypsin-Dependent Agrin Cleavage

(2009) Kazumasa Matsumoto-Miyai et al.   CELL

Neuronal caspase-3 signaling: not only cell death

(2009) M D'Amelio et al.   CELL DEATH AND DIFFERENTIATION

Protein translation in synaptic plasticity: mGluR-LTD, Fragile X

(2009) Maggie W Waung et al.   CURRENT OPINION IN NEUROBIOLOGY

N-methyl-d-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system

(2009) Ami Citri et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Regulation of the Proteasome by Neuronal Activity and Calcium/Calmodulin-dependent Protein Kinase II

(2009) Stevan N. Djakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subcomplexes of PA700, the 19 S Regulator of the 26 S Proteasome, Reveal Relative Roles of AAA Subunits in 26 S Proteasome Assembly and Activation and ATPase Activity

(2009) David Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Activity-Dependent Secretion of Brain-Derived Neurotrophic Factor from Axon and Dendrite

(2009) N. Matsuda et al.   JOURNAL OF NEUROSCIENCE

Matrix Metalloproteinase-9 Controls NMDA Receptor Surface Diffusion through Integrin  1 Signaling

(2009) P. Michaluk et al.   JOURNAL OF NEUROSCIENCE

Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP

(2009) J. Xu et al.   JOURNAL OF NEUROSCIENCE

Translational Control of Long-Lasting Synaptic Plasticity and Memory

(2009) Mauro Costa-Mattioli et al.   NEURON

Control of extracellular cleavage of ProBDNF by high frequency neuronal activity

(2009) G. Nagappan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Arc of synaptic memory

(2009) Clive R. Bramham et al.   EXPERIMENTAL BRAIN RESEARCH

Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting Complex

(2008) Lingyan Jin et al.   CELL

Neurotrypsin cleaves agrin locally at the synapse

(2008) Alexander Stephan et al.   FASEB JOURNAL

Important role of matrix metalloproteinase 9 in epileptogenesis

(2008) Grzegorz M. Wilczynski et al.   JOURNAL OF CELL BIOLOGY

Misplacement of Purkinje Cells during Postnatal Development in Bax Knock-Out Mice: A Novel Role for Programmed Cell Death in the Nervous System?

(2008) A-r. Jung et al.   JOURNAL OF NEUROSCIENCE

Activity-Induced Synaptic Capture and Exocytosis of the Neuronal Serine Protease Neurotrypsin

(2008) R. Frischknecht et al.   JOURNAL OF NEUROSCIENCE

Neuropsin (KLK8)-Dependent and -Independent Synaptic Tagging in the Schaffer-Collateral Pathway of Mouse Hippocampus

(2008) Y. Ishikawa et al.   JOURNAL OF NEUROSCIENCE

The Tyrosine Phosphatase STEP Mediates AMPA Receptor Endocytosis after Metabotropic Glutamate Receptor Stimulation

(2008) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Proteasome inhibition enhances the induction and impairs the maintenance of late-phase long-term potentiation

(2008) C. Dong et al.   LEARNING & MEMORY

Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains

(2008) Tudor Moldoveanu et al.   NATURE

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

(2008) Chanel J. Taylor et al.   NEUROBIOLOGY OF DISEASE

High resolution in situ zymography reveals matrix metalloproteinase activity at glutamatergic synapses

(2008) M. Gawlak et al.   NEUROSCIENCE

Extracellular proteolysis by matrix metalloproteinase-9 drives dendritic spine enlargement and long-term potentiation coordinately

(2008) X.-b. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA