The Medial Septum Is Insulin Resistant in the AD Presymptomatic Phase: Rescue by Nerve Growth Factor-Driven IRS1 Activation

Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease

(2017) Ramon Velazquez et al.   NEUROBIOLOGY OF AGING

The Input-Output Relationship of the Cholinergic Basal Forebrain

(2017) Matthew R. Gielow et al.   Cell Reports

Subcortical Shape Changes, Hippocampal Atrophy and Cortical Thinning in Future Alzheimer's Disease Patients

(2017) Andrea M. Kälin et al.   Frontiers in Aging Neuroscience

Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents

(2017) Nadia Canu et al.   Frontiers in Molecular Neuroscience

NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease

(2016) Viviana Triaca et al.   AGING CELL

Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I

(2016) Ana M. Fernandez et al.   DIABETES

Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline

(2016) Elizabeth C. Ballinger et al.   NEURON

Reference and working memory deficits in the 3xTg-AD mouse between 2 and 15-months of age: A cross-sectional study

(2015) Leanne M. Stevens et al.   BEHAVIOURAL BRAIN RESEARCH

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer’s disease

(2015) Alaina Baker-Nigh et al.   BRAIN

Alterations in synaptic plasticity coincide with deficits in spatial working memory in presymptomatic 3xTg-AD mice

(2015) Jason K. Clark et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Insulin resistance-induced hyperglycemia decreased the activation of Akt/CREB in hippocampus neurons: Molecular evidence for mechanism of diabetes-induced cognitive dysfunction

(2015) Qiong Xiang et al.   NEUROPEPTIDES

Modulation of Hippocampal Neural Plasticity by Glucose-Related Signaling

(2015) Marco Mainardi et al.   NEURAL PLASTICITY

Insulin Regulates the Activity of the High-Affinity Choline Transporter CHT

(2015) Katherine J. Fishwick et al.   PLoS One

THE 3XTG-AD MOUSE MODEL OF ALZHEIMER'S DISEASE EXHIBITS AGE-DEPENDENT IMPAIRED GLUCOSE TOLERANCE

(2014) Milene Vandal et al.   Alzheimers & Dementia

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

The Temporal Pattern of cfos Activation in Hypothalamic, Cortical, and Brainstem Nuclei in Response to Fasting and Refeeding in Male Mice

(2014) Qunli Wu et al.   ENDOCRINOLOGY

GLUT2-Mediated Glucose Uptake and Availability Are Required for Embryonic Brain Development in Zebrafish

(2014) Rubén Marín-Juez et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Nerve growth factor metabolic dysfunction in Alzheimer's disease and Down syndrome

(2014) M. Florencia Iulita et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Insulin in the Brain: Its Pathophysiological Implications for States Related with Central Insulin Resistance, Type 2 Diabetes and Alzheimer’s Disease

(2014) Enrique Blázquez et al.   Frontiers in Endocrinology

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2013) Jessica Freiherr et al.   CNS DRUGS

Nerve Growth Factor Receptor TrkA, a New Receptor in Insulin Signaling Pathway in PC12 Cells

(2013) Thangiah Geetha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetyl-CoA the Key Factor for Survival or Death of Cholinergic Neurons in Course of Neurodegenerative Diseases

(2013) Andrzej Szutowicz et al.   NEUROCHEMICAL RESEARCH

Intranasal Administration of CNS Therapeutics to Awake Mice

(2013) Leah R. Hanson et al.   Jove-Journal of Visualized Experiments

Contribution of serine racemase/d-serine pathway to neuronal apoptosis

(2012) Simona Esposito et al.   AGING CELL

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of NGF-TrkA Signaling from the CNS Is Not Sufficient to Induce Cognitive Impairments in Young Adult or Intermediate-Aged Mice

(2012) M. Muller et al.   JOURNAL OF NEUROSCIENCE

Regulation of glucose transport by insulin: traffic control of GLUT4

(2012) Dara Leto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior

(2012) Marina R. Picciotto et al.   NEURON

Insulin in the brain: There and back again

(2012) William A. Banks et al.   PHARMACOLOGY & THERAPEUTICS

Cortical Neurons Develop Insulin Resistance and Blunted Akt Signaling: A Potential Mechanism Contributing to Enhanced Ischemic Injury in Diabetes

(2011) Bhumsoo Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism

(2011) V. Ott et al.   DIABETES OBESITY & METABOLISM

Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimerʼs Disease

(2011) Suzanne M. de la Monte   DRUGS

Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models

(2010) Rachel M. Nicholson et al.   BRAIN RESEARCH

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice

(2010) Sylvia E. Perez et al.   NEUROBIOLOGY OF DISEASE

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3β signaling pathways and changes in protein expression

(2008) Ana I. Duarte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

(2008) Leah R Hanson et al.   BMC NEUROSCIENCE

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications

(2008) Elliott J Mufson et al.   Expert Review of Neurotherapeutics

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING