Success and failure in replication of genotype-phenotype associations: How does replication help in understanding the genetic basis of phenotypic variation in outbred populations?

Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals

(2018) Aniek C. Bouwman et al.   NATURE GENETICS

Fifteen years of quantitative trait loci studies in fish: challenges and future directions

(2017) David T. Ashton et al.   MOLECULAR ECOLOGY

Association mapping of morphological traits in wild and captive zebra finches: reliable within, but not between populations

(2017) Ulrich Knief et al.   MOLECULAR ECOLOGY

Long-term balancing selection on chromosomal variants associated with crypsis in a stick insect

(2017) Dorothea Lindtke et al.   MOLECULAR ECOLOGY

Am I ready for CRISPR? A user's guide to genetic screens

(2017) John G. Doench   NATURE REVIEWS GENETICS

Statistical correction of the Winner’s Curse explains replication variability in quantitative trait genome-wide association studies

(2017) Cameron Palmer et al.   PLoS Genetics

The evolutionary basis of premature migration in Pacific salmon highlights the utility of genomics for informing conservation

(2017) Daniel J. Prince et al.   Science Advances

A sex-chromosome inversion causes strong overdominance for sperm traits that affect siring success

(2017) Ulrich Knief et al.   Nature Ecology & Evolution

Transitions between phases of genomic differentiation during stick-insect speciation

(2017) Rüdiger Riesch et al.   Nature Ecology & Evolution

A sex-linked supergene controls sperm morphology and swimming speed in a songbird

(2017) Kang-Wook Kim et al.   Nature Ecology & Evolution

Red Carotenoid Coloration in the Zebra Finch Is Controlled by a Cytochrome P450 Gene Cluster

(2016) Nicholas I. Mundy et al.   CURRENT BIOLOGY

Color phenotypes are under similar genetic control in two distantly related species of Timema stick insect

(2016) Aaron A. Comeault et al.   EVOLUTION

Genes that affect Atlantic salmon growth in hatchery do not have the same effect in the wild

(2016) Anti Vasemägi et al.   FUNCTIONAL ECOLOGY

CRISPR/Cas9 in locusts: Successful establishment of an olfactory deficiency line by targeting the mutagenesis of an odorant receptor co-receptor (Orco)

(2016) Yan Li et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Controlling false discoveries in genome scans for selection

(2016) Olivier François et al.   MOLECULAR ECOLOGY

Genetic basis of adult migration timing in anadromous steelhead discovered through multivariate association testing

(2016) Jon E. Hess et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Selection on a Genetic Polymorphism Counteracts Ecological Speciation in a Stick Insect

(2015) Aaron A. Comeault et al.   CURRENT BIOLOGY

Commentary: When does understanding phenotypic evolution require identification of the underlying genes?

(2015) Mark D. Rausher et al.   EVOLUTION

The genetic basis of color-related local adaptation in a ring-like colonization around the Mediterranean

(2015) Reto Burri et al.   EVOLUTION

Heterogeneity of genetic architecture of body size traits in a free-living population

(2015) Camillo Bérénos et al.   MOLECULAR ECOLOGY

Replicated analysis of the genetic architecture of quantitative traits in two wild great tit populations

(2015) Anna W. Santure et al.   MOLECULAR ECOLOGY

Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon

(2015) Nicola J. Barson et al.   NATURE

Structural genomic changes underlie alternative reproductive strategies in the ruff (Philomachus pugnax)

(2015) Sangeet Lamichhaney et al.   NATURE GENETICS

A supergene determines highly divergent male reproductive morphs in the ruff

(2015) Clemens Küpper et al.   NATURE GENETICS

Challenges and prospects in genome-wide quantitative trait loci mapping of standing genetic variation in natural populations

(2014) Holger Schielzeth et al.   Annals of the New York Academy of Sciences

Genome-wide SNP analysis reveals a genetic basis for sea-age variation in a wild population of Atlantic salmon (Salmo salar)

(2014) Susan E. Johnston et al.   MOLECULAR ECOLOGY

Sexual selection and genetic colour polymorphisms in animals

(2014) Maren Wellenreuther et al.   MOLECULAR ECOLOGY

doublesex is a mimicry supergene

(2014) K. Kunte et al.   NATURE

Targeted Mutagenesis in Atlantic Salmon (Salmo salar L.) Using the CRISPR/Cas9 System Induces Complete Knockout Individuals in the F0 Generation

(2014) Rolf B. Edvardsen et al.   PLoS One

Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations

(2014) Yun R Li et al.   Genome Medicine

Identifying the genes underlying quantitative traits: a rationale for the QTN programme

(2014) Young Wha Lee et al.   AoB Plants

Genetic mapping of the female mimic morph locus in the ruff

(2013) Lindsay L Farrell et al.   BMC GENETICS

Detection of Quantitative Trait Loci (QTL) Related to Grilsing and Late Sexual Maturation in Atlantic Salmon (Salmo salar)

(2013) Alejandro P. Gutierrez et al.   MARINE BIOTECHNOLOGY

Haplotype structure, adaptive history and associations with exploratory behaviour of theDRD4gene region in four great tit (Parus major) populations

(2013) Jakob C. Mueller et al.   MOLECULAR ECOLOGY

RAD-Seq derived markers flank the shell colour and banding loci of theCepaea nemoralissupergene

(2013) Paul M. Richards et al.   MOLECULAR ECOLOGY

QST–FST comparisons: evolutionary and ecological insights from genomic heterogeneity

(2013) Tuomas Leinonen et al.   NATURE REVIEWS GENETICS

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Challenges and opportunities in genome-wide environmental interaction (GWEI) studies

(2012) Hugues Aschard et al.   HUMAN GENETICS

Selection and microevolution of coat pattern are cryptic in a wild population of sheep

(2012) J. GRATTEN et al.   MOLECULAR ECOLOGY

QTL and quantitative genetic analysis of beak morphology reveals patterns of standing genetic variation in an Estrildid finch

(2012) ULRICH KNIEF et al.   MOLECULAR ECOLOGY

The design and cross-population application of a genome-wide SNP chip for the great tit Parus major

(2012) NIKKIE E. M. Van BERS et al.   Molecular Ecology Resources

Animal QTLdb: an improved database tool for livestock animal QTL/association data dissemination in the post-genome era

(2012) Zhi-Liang Hu et al.   NUCLEIC ACIDS RESEARCH

Bayesian variable selection regression for genome-wide association studies and other large-scale problems

(2011) Yongtao Guan et al.   Annals of Applied Statistics

A Systematic Review of Replication Studies of Prostate Cancer Susceptibility Genetic Variants in High-Risk Men Originally Identified from Genome-Wide Association Studies

(2011) M. B. Ishak et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

QTL LINKAGE MAPPING OF ZEBRA FINCH BEAK COLOR SHOWS AN OLIGOGENIC CONTROL OF A SEXUALLY SELECTED TRAIT

(2011) Holger Schielzeth et al.   EVOLUTION

Consistency of genome-wide associations across major ancestral groups

(2011) Evangelia E. Ntzani et al.   HUMAN GENETICS

BR-squared: a practical solution to the winner’s curse in genome-wide scans

(2011) Lei Sun et al.   HUMAN GENETICS

QTL linkage mapping of wing length in zebra finch using genome-wide single nucleotide polymorphisms markers

(2011) HOLGER SCHIELZETH et al.   MOLECULAR ECOLOGY

Genome-wide association mapping identifies the genetic basis of discrete and quantitative variation in sexual weaponry in a wild sheep population

(2011) SUSAN E. JOHNSTON et al.   MOLECULAR ECOLOGY

Chromosomal rearrangements maintain a polymorphic supergene controlling butterfly mimicry

(2011) Mathieu Joron et al.   NATURE

Improving Validation Practices in "Omics" Research

(2011) J. P. A. Ioannidis et al.   SCIENCE

Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies

(2010) Konstantinos C M Siontis et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The recombination landscape of the zebra finch Taeniopygia guttata genome

(2010) N. Backstrom et al.   GENOME RESEARCH

Association between DRD4 gene polymorphism and personality variation in great tits: a test across four wild populations

(2010) PETER KORSTEN et al.   MOLECULAR ECOLOGY

Variance component model to account for sample structure in genome-wide association studies

(2010) Hyun Min Kang et al.   NATURE GENETICS

New approaches to population stratification in genome-wide association studies

(2010) Alkes L. Price et al.   NATURE REVIEWS GENETICS

Association genetics of complex traits in plants

(2010) Pär K. Ingvarsson et al.   NEW PHYTOLOGIST

Convergence in pigmentation at multiple levels: mutations, genes and function

(2010) M. Manceau et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Genome mapping in intensively studied wild vertebrate populations

(2010) Jon Slate et al.   TRENDS IN GENETICS

A Widespread Chromosomal Inversion Polymorphism Contributes to a Major Life-History Transition, Local Adaptation, and Reproductive Isolation

(2010) David B. Lowry et al.   PLOS BIOLOGY

Regressive Evolution inAstyanaxCavefish

(2009) William R. Jeffery   Annual Review of Genetics

Genetic architecture of quantitative traits in mice, flies, and humans

(2009) J. Flint et al.   GENOME RESEARCH

The genetic basis of recessive self-colour pattern in a wild sheep population

(2009) J Gratten et al.   HEREDITY

Horn type and horn length genes map to the same chromosomal region in Soay sheep

(2009) S E Johnston et al.   HEREDITY

Genome-wide association studies in Alzheimer's disease

(2009) L. Bertram et al.   HUMAN MOLECULAR GENETICS

Human genetic variation and its contribution to complex traits

(2009) Kelly A. Frazer et al.   NATURE REVIEWS GENETICS

Validating, augmenting and refining genome-wide association signals

(2009) John P. A. Ioannidis et al.   NATURE REVIEWS GENETICS

The genetics of quantitative traits: challenges and prospects

(2009) Trudy F. C. Mackay et al.   NATURE REVIEWS GENETICS

Association Mapping: Critical Considerations Shift from Genotyping to Experimental Design

(2009) S. Myles et al.   PLANT CELL

Failure to Replicate a Genetic Association May Provide Important Clues About Genetic Architecture

(2009) Casey S. Greene et al.   PLoS One

Adaptive Evolution of Pelvic Reduction in Sticklebacks by Recurrent Deletion of a Pitx1 Enhancer

(2009) Y. F. Chan et al.   SCIENCE

From mutations to MAGIC: resources for gene discovery, validation and delivery in crop plants

(2008) Colin Cavanagh et al.   CURRENT OPINION IN PLANT BIOLOGY

The art and design of genetic screens: RNA interference

(2008) Michael Boutros et al.   NATURE REVIEWS GENETICS

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS

Genetic Mapping in Human Disease

(2008) D. Altshuler et al.   SCIENCE

A Localized Negative Genetic Correlation Constrains Microevolution of Coat Color in Wild Sheep

(2008) J. Gratten et al.   SCIENCE