Vacuole-mediated selective regulation of TORC1-Sch9 signaling following oxidative stress

Novel tRNA function in amino acid sensing of yeast Tor complex1

(2017) Yoshiaki Kamada   GENES TO CELLS

Localization of mTORC2 activity inside cells

(2017) Michael Ebner et al.   JOURNAL OF CELL BIOLOGY

An In Vitro TORC1 Kinase Assay That Recapitulates the Gtr-Independent Glutamine-Responsive TORC1 Activation Mechanism on Yeast Vacuoles

(2017) Mirai Tanigawa et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional mapping of yeast genomes by saturated transposition

(2017) Agnès H Michel et al.   eLife

Ste12/Fab1 phosphatidylinositol-3-phosphate 5-kinase is required for nitrogen-regulated mitotic commitment and cell size control

(2017) David Cobley et al.   PLoS One

Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot

(2016) Deborah C.I. Goberdhan et al.   Cell Metabolism

PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment

(2016) Shefali Krishna et al.   DEVELOPMENTAL CELL

Dynamic relocation of the TORC1–Gtr1/2–Ego1/2/3 complex is regulated by Gtr1 and Gtr2

(2016) Shintaro Kira et al.   MOLECULAR BIOLOGY OF THE CELL

Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation

(2016) Eisuke Itakura et al.   MOLECULAR CELL

Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling

(2015) Katie Powis et al.   CELL RESEARCH

A LAPF/phafin1-like protein regulates TORC1 and lysosomal membrane permeabilization in response to endoplasmic reticulum membrane stress

(2015) Adam Kim et al.   MOLECULAR BIOLOGY OF THE CELL

Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2

(2015) Marie-Pierre Péli-Gulli et al.   Cell Reports

Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast

(2015) James E Hughes Hallett et al.   eLife

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

(2014) Shintaro Kira et al.   Autophagy

State Transitions in the TORC1 Signaling Pathway and Information Processing in Saccharomyces cerevisiae

(2014) J. E. Hughes Hallett et al.   GENETICS

Endolysosomal Membrane Trafficking Complexes Drive Nutrient-Dependent TORC1 Signaling to Control Cell Growth inSaccharomyces cerevisiae

(2014) Joanne M. Kingsbury et al.   GENETICS

Nitrogen Source Activates TOR (Target of Rapamycin) Complex 1 via Glutamine and Independently of Gtr/Rag Proteins

(2014) Daniele Stracka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles for PI(3,5)P2 in nutrient sensing through TORC1

(2014) Natsuko Jin et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphatidylinositol 3,5-bisphosphate: Low abundance, high significance

(2013) Amber J. McCartney et al.   BIOESSAYS

Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells

(2013) Kathrin Thedieck et al.   CELL

CORVET and HOPS tethering complexes - coordinators of endosome and lysosome fusion

(2013) H. J. k. Balderhaar et al.   JOURNAL OF CELL SCIENCE

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

(2013) Zhi-Yang Tsun et al.   MOLECULAR CELL

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

(2013) S. A. Kang et al.   SCIENCE

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1

(2013) N. Panchaud et al.   Science Signaling

Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast

(2012) Dries Castermans et al.   CELL RESEARCH

Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1

(2012) Dave Bridges et al.   MOLECULAR BIOLOGY OF THE CELL

Transient Sequestration of TORC1 into Stress Granules during Heat Stress

(2012) Terunao Takahara et al.   MOLECULAR CELL

Leucyl-tRNA Synthetase Controls TORC1 via the EGO Complex

(2012) Grégory Bonfils et al.   MOLECULAR CELL

TORC1 Regulates Endocytosis via Npr1-Mediated Phosphoinhibition of a Ubiquitin Ligase Adaptor

(2011) Jason A. MacGurn et al.   CELL

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

(2011) Robbie Loewith et al.   GENETICS

Redox Regulates Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity by Modulating the TSC1/TSC2-Rheb GTPase Pathway

(2011) Sei Yoshida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Seamless Gene Tagging by Endonuclease-Driven Homologous Recombination

(2011) Anton Khmelinskii et al.   PLoS One

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Stressin' Sestrins take an aging fight

(2010) Andrei V. Budanov et al.   EMBO Molecular Medicine

Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function

(2009) Stephen K. Dove et al.   BIOCHEMICAL JOURNAL

Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis

(2009) A. Huber et al.   GENES & DEVELOPMENT

Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy

(2009) Y. Kamada et al.   MOLECULAR AND CELLULAR BIOLOGY

The Vam6 GEF Controls TORC1 by Activating the EGO Complex

(2009) Matteo Binda et al.   MOLECULAR CELL

The yeast lysosome-like vacuole: Endpoint and crossroads

(2008) Sheena Claire Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Caffeine extends yeast lifespan by targeting TORC1

(2008) Valeria Wanke et al.   MOLECULAR MICROBIOLOGY

Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9

(2008) Min Wei et al.   PLoS Genetics

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE