Article
Gastroenterology & Hepatology
Junyong Wang, Junpeng Ma, Hongyu Nie, Xiao-Jing Zhang, Peng Zhang, Zhi-Gang She, Hongliang Li, Yan-Xiao Ji, Jingjing Cai
Summary: The study found that RGS5 protects against NAFLD and nonalcoholic steatohepatitis, and that it is negatively associated with mitogen-activated protein kinase signaling cascades in response to metabolic challenges. RGS5 directly interacts with TAK1, inhibits its hyperphosphorylation, and prevents the activation of the downstream JNK/p38 signaling cascade.
Review
Immunology
Mohamed E. Shaker, Hesham A. M. Gomaa, Mohamed A. Abdelgawad, Mohamed El-Mesery, Ahmed A. Shaaban, Sara H. Hazem
Summary: This review discusses the impact of inflammation on liver diseases and the role of TLRs, such as TLR4 and TLR9, in liver diseases. It also explores the functions of tyrosine kinases (TKs) and their regulation in hepatic inflammation. The review highlights the importance of studying the role of these TKs in order to develop new therapeutic approaches for liver diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Ying Zhu, Jianguo Xu, Wei Hu, Fang Wang, Yan Zhou, Wei Gong, Wen Xu
Summary: The study found that the upregulation of USP8 in HCC patients is not associated with drug resistance, and inhibiting USP8 can suppress HCC cell growth, induce apoptosis, enhance the efficacy of doxorubicin or sorafenib, and may serve as a therapeutic target for HCC.
Review
Oncology
Chih-Hung Hsu, Yi-Hsiang Huang, Shi-Ming Lin, Chiun Hsu
Summary: AXL and MET play key roles in the progression, treatment resistance, and immunomodulation of HCC. Continued development of drugs that target these receptor tyrosine kinases appears likely to represent a useful strategy to improve outcomes for patients with HCC.
Article
Chemistry, Medicinal
Kenia Ubieta, Matthew James Thomas, Lutz Wollin
Summary: The study revealed that nintedanib blocks T-cell activation by inhibiting Lck-Y394 phosphorylation, reduces cluster formation as a marker of activation, and inhibits the release of various cytokines. These immunomodulatory effects further explain how nintedanib slows the progression of pulmonary fibrosis in different ILDs.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Wenqi Li, Shuwen Zhu, Jing Liu, Zhigang Liu, Honggang Zhou, Qianyi Zhang, Yue Yang, Li Chen, Xiaowei Guo, Tiantian Zhang, Lingxin Meng, Dan Chai, Guodong Tang, Xiaohe Li, Cheng Yang
Summary: This study demonstrates that Zanubrutinib can alleviate β-adrenergic receptor-induced cardiac fibrosis and inflammation, acting through the BTK, STAT3, NF-kappa B, and PI3K/Akt signaling pathways both in vivo and in vitro.
Review
Pharmacology & Pharmacy
Soumyadeep Dey, Jeeyoung Lee, Constance T. Noguchi
Summary: EPO, through EPOR expression, exerts protective effects in non-hematopoietic tissues, influencing metabolism in the brain, fat, and bones, especially in regulating obesity and inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dermatology
Qinqin Meng, Mei Bai, Meiliang Guo, Zhengxiao Li, Wanwen Liu, Xiaojing Fan, Rui Sun, Xinrong Yang, Dingfen Yuan, Yuling Shi, Hui Deng
Summary: The regulatory role of SGK1 in psoriasis and its underlying molecular mechanism are not well understood. This study found that SGK1 expression was decreased in macrophages from psoriasis patients. Moreover, SGK1 inhibition enhanced toll-like receptor 7/8 activation and proinflammatory cytokine production.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Fu-Ling Chang, Keng-Chang Tsai, Tsai-Yu Lin, Chen-Wei Chiang, Shiow-Lin Pan, Yu-Ching Lee
Summary: This study isolated specific antibodies using phage display and validated the therapeutic efficacy and inhibition mechanism of the antibodies against pancreatic cancer. The antibodies induced cellular endocytosis and degradation of EphA2, weakening molecular signals and inhibiting proliferation and migration of pancreatic cancer cells. The humanized antibody effectively inhibited the growth of xenograft pancreatic cancer tumor cells and showed improved tumor growth inhibition when administered with gemcitabine.
Article
Pharmacology & Pharmacy
Qian Liu, Lijuan Hua, Chen Bao, Luxia Kong, Jiannan Hu, Chao Liu, Ziling Li, Shuyun Xu, Xiansheng Liu
Summary: The Syk inhibitor R406 improves sensitivity to dexamethasone by modulating GR, providing a reference for the development of drugs to treat severe steroid-resistant asthma.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Manali Tilak, Jennifer Holborn, Laura A. New, Jasmin Lalonde, Nina Jones
Summary: Glioblastoma multiforme (GBM) is a deadly cancer with limited response to existing therapies. Subtypes of GBM with distinct genetic signatures show aberrant activation of signal transduction pathways. Current research focuses on understanding these molecular alterations to develop more efficient targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Neil Bate, James Lodge, Nicholas P. J. Brindle
Summary: This study enhanced the binding affinity of Tie2 Ectodomain trap for Ang2 using directed protein evolution and revealed different contributions of Tie2 residues to binding of Ang1 and Ang2. It also identified selectivity-determining residues that could be targeted for the design of inhibitors of Ang2 in the treatment of vascular dysfunction.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Oncology
Viola Hedrich, Kristina Breitenecker, Leila Djerlek, Gregor Ortmayr, Wolfgang Mikulits
Summary: The receptor tyrosine kinases Tyro3, Axl, and MerTK of the TAM family play a significant role in hepatocellular carcinoma progression. They exert their impact on cancer biology by modulating epithelial cell plasticity and promoting metastatic traits of neoplastic hepatocytes. By activating TAM receptors, they influence anti-inflammatory responses, vessel integrity, and resistance to chemotherapy.
Review
Gastroenterology & Hepatology
Lorenza Rimassa, Richard S. Finn, Bruno Sangro
Summary: Single-agent immune checkpoint inhibitors (ICIs) have limited efficacy in advanced hepatocellular carcinoma (HCC) patients, and approximately 30% of patients show intrinsic resistance to ICIs. Therefore, researchers are exploring combination therapies, such as anti-angiogenic agents and other ICIs. Some trials have shown promising results and potential for clinical application. However, there are still many unanswered questions that require further research.
JOURNAL OF HEPATOLOGY
(2023)
Article
Oncology
Hongli Liu, Yuzhi Li, Jing Zhang, Nan Wu, Fei Liu, Lihua Wang, Yuan Zhang, Jing Liu, Xuan Zhang, Suyang Guo, Hongtao Wang
Summary: The study revealed ERBB2 as an oncogenic protein that may promote invasiveness in cervical cancer cells, and miR-3184-5p can directly suppress ERBB2 expression. Treatment of cervical cancer cells with the p53 activator Mithramycin A, which restores miR-3184-5p levels, can decrease ERBB2 expression and attenuate proliferation and migration of cervical cancer cells.
Article
Immunology
Logan K. Smith, Giselle M. Boukhaled, Stephanie A. Condotta, Sabrina Mazouz, Jenna J. Guthmiller, Rahul Vijay, Noah S. Butler, Julie Bruneau, Naglaa H. Shoukry, Connie M. Krawczyk, Martin J. Richer
Correction
Cell Biology
Ryan A. Zander, Rahul Vijay, Angela D. Pack, Jenna J. Guthmiller, Amy C. Graham, Scott E. Lindner, Ashley M. Vaughan, Stefan H. I. Kappe, Noah S. Butler
Article
Infectious Diseases
Bethany Brunton, Kai Rogers, Elisabeth K. Phillips, Rachel B. Brouillette, Ruayda Bouls, Noah S. Butler, Wendy Maury
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Cell Biology
Kai J. Rogers, Olena Shtanko, Laura L. Stunz, Laura N. Mallinger, Tina Arkee, Megan E. Schmidt, Dana Bohan, Bethany Brunton, Judith M. White, Steve M. Varga, Noah S. Butler, Gail A. Bishop, Wendy Maury
Summary: CD40 expression in peritoneal M phi s restricts early infection of a broad range of RNA viruses. CD154/CD40 interactions stimulate IL-12 production, leading to IFN-gamma production and proinflammatory polarization of M phi s, protecting the cells from infection. These CD40-dependent events protect mice against virus challenge.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Immunology
Rahul Vijay, Jenna J. Guthmiller, Alexandria J. Sturtz, Fionna A. Surette, Kai J. Rogers, Ramakrishna R. Sompallae, Fengyin Li, Rosemary L. Pope, Jo-Anne Chan, Fabian de Labastida Rivera, Dean Andrew, Lachlan Webb, Wendy J. Maury, Hai-Hui Xue, Christian R. Engwerda, James S. McCarthy, Michelle J. Boyle, Noah S. Butler
Article
Cell Biology
Kai J. Rogers, Olena Shtanko, Rahul Vijay, Laura N. Mallinger, Chester J. Joyner, Mary R. Galinski, Noah S. Butler, Wendy Maury
Article
Immunology
Isaac J. Jensen, Patrick W. McGonagill, Noah S. Butler, John T. Harty, Thomas S. Griffith, Vladimir P. Badovinac
Summary: NK cells play a critical role in host survival during sepsis by limiting the scope and duration of the cytokine storm, with NK cell-derived IL-10 being crucial for survival in septic patients. This demonstrates the beneficial regulatory mechanisms of NK cells in controlling systemic inflammation during dysregulated infection-induced inflammatory responses.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Kai J. Rogers, Rahul Vijay, Noah S. Butler
Summary: Humoral immunity plays a critical role in limiting Plasmodium parasite infections and the severity of malaria. Naturally acquired immunity against malaria is inefficient and protection is relatively short-lived. Recent advances have been made in understanding the molecular and cellular pathways that regulate Plasmodium parasite-specific B cell responses and durable anti-malarial humoral immunity.
MICROBES AND INFECTION
(2021)
Article
Microbiology
Fionna A. Surette, Jenna J. Guthmiller, Lei Li, Alexandria J. Sturtz, Rahul Vijay, Rosemary L. Pope, Brandon L. McClellan, Angela D. Pack, Ryan A. Zander, Peng Shao, Linda Yu-Ling Lan, Daniel Fernandez-Ruiz, William R. Heath, Patrick C. Wilson, Noah S. Butler
Summary: IL-10 plays a critical role in promoting humoral immunity during blood-stage Plasmodium infection within the first 96 hours, primarily through B cell intrinsic mechanisms. This information may lead to new strategies for combating malaria.
Article
Immunology
Rahul Vijay, Jenna J. Guthmiller, Alexandria J. Sturtz, Sequoia Crooks, Jordan T. Johnson, Lei Li, Linda Yu-Ling Lan, Rosemary L. Pope, Yani Chen, Kai J. Rogers, Nirmal Dutta, Jason E. Toombs, Mary E. Wilson, Patrick C. Wilson, Wendy Maury, Rolf A. Brekken, Noah S. Butler
Summary: This study uncovers the mechanistic link between hemolysis-induced exposure of phosphatidylserine on damaged RBCs and the formation of plasmablast populations in Plasmodium-infected hosts. Additionally, it shows that virus and Trypanosoma infections triggering hemolytic anemia and inflammation also induce exuberant plasmablast responses. Furthermore, targeting polyclonal B cell activation and phosphatidylserine exposure may enhance immune responses against Plasmodium parasites and other infectious diseases associated with anemia.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Cell Biology
Angela D. Pack, Patrick Schwartzhoff, Zeb R. Zacharias, Daniel Fernandez-Ruiz, William R. Heath, Prajwal Gurung, Kevin L. Legge, Chris J. Janse, Noah S. Butler
Summary: During acute malaria, hemozoin deposition limits conventional dendritic cell function, resulting in aberrant T cell responses and impaired B cell and plasma cell formation, highlighting immune evasion mechanisms following initial Plasmodium exposure.
Article
Biology
Scott M. Anthony, Natalija Van Braeckel-Budimir, Steven J. Moioffer, Stephanie van de Wall, Qiang Shan, Rahul Vijay, Ramakrishna Sompallae, Stacey M. Hartwig, Isaac J. Jensen, Steven M. Varga, Noah S. Butler, Hai-Hui Xue, Vladimir P. Badovinac, John T. Harty
Summary: IAV infection generates Trm CD8(+)T cells in mice, while repeated antigen exposure produces 4M CD8(+)T cells with enhanced protective capacity. Enhanced protection by 4M cells is associated with increased expression of granzyme A/B and stable maintenance of CD69(+)CD103(+) 4M CD8(+)T cells, improving control of viral infections in mLN.
Article
Cell Biology
Mitchell N. Lefebvre, Fionna A. Surette, Scott M. Anthony, Rahul Vijay, Isaac J. Jensen, Lecia L. Pewe, Lisa S. Hancox, Natalija Van Braeckel-Budimir, Stephanie van de Wall, Stina L. Urban, Madison R. Mix, Samarchith P. Kurup, Vladimir P. Badovinac, Noah S. Butler, John T. Harty
Summary: The study shows that effector memory CD8 T cells rapidly infiltrate the liver after malarial infection, mediating pathogen clearance through upregulation of inflammatory genes. This highlights the crucial role of Tem in protecting against malaria infection.
Review
Immunology
Samarchith P. Kurup, Noah S. Butler, John T. Harty
NATURE REVIEWS IMMUNOLOGY
(2019)
Article
Medicine, Research & Experimental
William O. Hahn, Noah S. Butler, Scott E. Lindner, Holly M. Akilesh, D. Noah Sather, Stefan H. I. Kappe, Jessica A. Hamerman, Michael Gale, W. Conrad Liles, Marion Pepper
