Article
Immunology
Raji Balasubramanian, Katherine H. Shutta, Marta Guasch-Ferre, Tianyi Huang, Shaili C. Jha, Yiwen Zhu, Aladdin H. Shadyab, JoAnn E. Manson, Dolores Corella, Montserrat Fito, Frank B. Hu, Kathryn M. Rexrode, Clary B. Clish, Susan E. Hankinson, Laura D. Kubzansky
Summary: Chronic psychological distress is associated with increased risk of cardiovascular disease, and inflammatory factors may play a crucial role in this association. This study found that a metabolite profile linked with distress was associated with increased risk of CVD and inflammation-related risk factors.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Environmental Sciences
Farooq Ahmad, Samar A. Abubshait, Haya A. Abubshait
Summary: Engineered nanomaterials (ENM) are extensively used in various industries due to their superior properties. These materials can enter the human body through different exposure routes, causing metabolic dysregulation. Advances in metabolomics technology allow us to study the metabolic disturbances induced by ENM.
Article
Chemistry, Analytical
Jeany Delafiori, Luiz Claudio Navarro, Rinaldo Focaccia Siciliano, Gisely Cardoso de Melo, Estela Natacha Brandt Busanello, Jose Carlos Nicolau, Geovana Manzan Sales, Arthur Noin de Oliveira, Fernando Fonseca Almeida Val, Diogo Noin de Oliveira, Adriana Eguti, Luiz Augusto dos Santos, Talia Falcao Dalcoquio, Adriadne Justi Bertolin, Rebeca Linhares Abreu-Netto, Rocio Salsoso, Djane Baia-da-Silva, Fabiana G. Marcondes-Braga, Vanderson Souza Sampaio, Carla Cristina Judice, Fabio Trindade Maranhao Costa, Nelson Duran, Mauricio Wesley Perroud, Ester Cerdeira Sabino, Marcus Vinicius Guimaraes Lacerda, Leonardo Oliveira Reis, Wagner Jose Favaro, Wuelton Marcelo Monteiro, Anderson Rezende Rocha, Rodrigo Ramos Catharino
Summary: COVID-19 continues to pose a heavy burden worldwide, emphasizing the importance of patient screening and risk management. Our integration of machine learning algorithms with mass spectrometry led to the development of a rapid platform for distinguishing COVID-19 in plasma samples and providing tools for risk assessment, aiding in patient management and decision-making.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Sajedeh Rezaei Cherati, Muhammad Anas, Shijie Liu, Sudha Shanmugam, Kamal Pandey, Steven Angtuaco, Randal Shelton, Aida N. Khalfaoui, Savenka Alena, Erin Porter, Todd Fite, Huaixuan Cao, Micah J. Green, Alexei G. Basnakian, Mariya V. Khodakovskaya
Summary: This study comprehensively investigates the accumulation of multiwalled carbon nanotubes (CNTs) in tomato plant organs and the potential health risks for mice. The results show that the amount of CNTs accumulated in plant organs as a result of nanofertilization is not sufficient to induce toxicity in mice.
Article
Psychology, Multidisciplinary
Yingbo Shao, Haoyu Zhang, Xiaonan Zhang, Qian Liang, Hui Zhang, Feifei Zhang
Summary: This research conducted a large sample behavioral study to examine the reliability and validity of the Chinese version of the Exercise Dependence Scale-Revised (EDS-R) and explore the social and psychological factors related to exercise addiction.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
Zhenyan Zhang, Qi Zhang, Tingzhang Wang, Nuohan Xu, Tao Lu, Wenjie Hong, Josep Penuelas, Michael Gillings, Meixia Wang, Wenwen Gao, Haifeng Qian
Summary: The study analyzes 4572 metagenomic samples to illustrate the global patterns of antibiotic resistance gene (ARG) distribution in diverse habitats. They quantitatively evaluate the health risk to humans of 2561 ARGs by integrating human accessibility, mobility, pathogenicity, and clinical availability. With machine learning, they map the antibiotic resistance threats in global marine habitats with over 75% accuracy.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Lili Lu, Christina S. Mullins, Clemens Schafmayer, Sebastian Zeissig, Michael Linnebacher
Summary: Gastrointestinal (GI) cancers exhibit regional differences in incidence, mortality, and prevalence worldwide, with higher mortality rates in developing countries possibly due to inadequate prevention and treatment strategies. The prevalence of GI cancers is positively correlated with national human development indices and lifestyle-associated risk factors, but negatively correlated with hypertension and diabetes.
CANCER COMMUNICATIONS
(2021)
Article
Environmental Studies
Nadine Heck, Michael W. Beck, Borja Reguero, Kerstin Pfliegner, Max Ricker, Ruben Pruetz
Summary: Our study explores the variations in risks faced by fishery-dependent coastal nations due to ocean acidification, sea surface temperature change, sea level rise, and storms. We found that the risks differ based on geographical location and development status of a country. The study suggests the need for region-specific strategies to reduce risks, as well as the importance of considering national indicators for a more nuanced understanding of risk patterns.
Article
Environmental Sciences
Jin Zhang, Lu Ma, Boyan Li, Xiong Chen, Dapeng Wang, Aihua Zhang
Summary: This study identified metabolic biomarkers associated with arsenicosis using untargeted metabolomics and machine learning algorithms. A total of 143 metabolic biomarkers, mainly organic acids, were found to be closely associated with arsenicosis. The disrupted metabolisms of beta-alanine and arginine were the most significant in arsenicosis patients with different symptom severity. Metabolic biomarkers combined with machine learning algorithms can be efficient for risk assessment and early identification of arsenicosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Bethany L. Clark, Ana P. B. Carneiro, Elizabeth J. Pearmain, Marie-Morgane Rouyer, Thomas A. Clay, Win Cowger, Richard A. Phillips, Andrea Manica, Carolina Hazin, Marcus Eriksen, Jacob Gonzalez-Solis, Josh Adams, Yuri V. Albores-Barajas, Joanna Alfaro-Shigueto, Maria Saldanha Alho, Deusa Teixeira Araujo, Jose Manuel Arcos, John P. Y. Arnould, Nadito J. P. Barbosa, Christophe Barbraud, Annalea M. Beard, Jessie Beck, Elizabeth A. Bell, Della G. Bennet, Maud Berlincourt, Manuel Biscoito, Oskar K. Bjornstad, Mark Bolton, Katherine A. Booth Jones, John J. Borg, Karen Bourgeois, Vincent Bretagnolle, Joel Bried, James V. Briskie, M. de L. Brooke, Katherine C. Brownlie, Leandro Bugoni, Licia Calabrese, Letizia Campioni, Mark J. Carey, Ryan D. Carle, Nicholas Carlile, Ana R. Carreiro, Paulo Catry, Teresa Catry, Jacopo G. Cecere, Filipe R. Ceia, Yves Cherel, Chang-Yong Choi, Marco Cianchetti-Benedetti, Rohan H. Clarke, Jaimie B. Cleeland, Valentina Colodro, Bradley C. Congdon, Johannis Danielsen, Federico De Pascalis, Zoe Deakin, Nina Dehnhard, Giacomo Dell'Omo, Karine Delord, Sebastien Descamps, Ben J. Dilley, Herculano A. Dinis, Jerome Dubos, Brendon J. Dunphy, Louise M. Emmerson, Ana Isabel Fagundes, Annette L. Fayet, Jonathan J. Felis, Johannes H. Fischer, Amanda N. D. Freeman, Aymeric Fromant, Giorgia Gaibani, David Garcia, Carina Gjerdrum, Ivandra Soeli Goncalves Correia Gomes, Manuela G. Forero, Jose P. Granadeiro, W. James Grecian, David Gremillet, Tim Guilford, Gunnar Thor Hallgrimsson, Luke R. Halpin, Erpur Snaer Hansen, April Hedd, Morten Helberg, Halfdan H. Helgason, Leeann M. Henry, Hannah F. R. Hereward, Marcos Hernandez-Montero, Mark A. Hindell, Peter J. Hodum, Simona Imperio, Audrey Jaeger, Mark Jessopp, Patrick G. R. Jodice, Carl G. Jones, Christopher W. Jones, Jon Einar Jonsson, Adam Kane, Sven Kapelj, Yuna Kim, Holly Kirk, Yann Kolbeinsson, Philipp L. Kraemer, Lucas Krueger, Paulo Lago, Todd J. Landers, Jennifer L. Lavers, Matthieu Le Corre, Andreia Leal, Maite Louzao, Jeremy Madeiros, Maria Magalhaes, Mark L. Mallory, Juan F. Masello, Bruno Massa, Sakiko Matsumoto, Fiona McDuie, Laura McFarlane Tranquilla, Fernando Medrano, Benjamin J. Metzger, Teresa Militao, William A. Montevecchi, Rosalinda C. Montone, Leia Navarro-Herrero, Veronica C. Neves, David G. Nicholls, Malcolm A. C. Nicoll, Ken Norris, Steffen Oppel, Daniel Oro, Ellie Owen, Oliver Padget, Vitor H. Paiva, David Pala, Jorge M. Pereira, Clara Peron, Maria V. Petry, Admilton de Pina, Ariete T. Moreira Pina, Patrick Pinet, Pierre A. Pistorius, Ingrid L. Pollet, Benjamin J. Porter, Timothee A. Poupart, Christopher D. L. Powell, Carolina B. Proano, Julia Pujol-Casado, Petra Quillfeldt, John L. Quinn, Andre F. Raine, Helen Raine, Ivan Ramirez, Jaime A. Ramos, Rauel Ramos, Andreas Ravache, Matt J. Rayner, Timothy A. Reid, Gregory J. Robertson, Gerard J. Rocamora, Dominic P. Rollinson, Robert A. Ronconi, Andreu Rotger, Diego Rubolini, Kevin Ruhomaun, Asuncion Ruiz, James C. Russell, Peter G. Ryan, Sarah Saldanha, Ana Sanz-Aguilar, Mariona Sarda-Serra, Yvan G. Satge, Katsufumi Sato, Wiebke C. Schaefer, Stefan Schoombie, Scott A. Shaffer, Nirmal Shah, Akiko Shoji, Dave Shutler, Ingvar A. Sigurosson, Monica C. Silva, Alison E. Small, Cecilia Soldatini, Hallvard Strom, Christopher A. Surman, Akinori Takahashi, Vikash R. V. Tatayah, Graeme A. Taylor, Robert J. Thomas, David R. Thompson, Paul M. Thompson, Thorkell L. Thorarinsson, Diego Vicente-Sastre, Eric Vidal, Ewan D. Wakefield, Susan M. Waugh, Henri Weimerskirch, Heiko U. Wittmer, Takashi Yamamoto, Ken Yoda, Carlos B. Zavalaga, Francis J. Zino, Maria P. Dias
Summary: Plastic pollution and vulnerable marine organisms have uneven distributions. This study combines plastic density estimates and bird movement data to estimate exposure risk. The Mediterranean, Black seas, northeast Pacific, northwest Pacific, South Atlantic, and southwest Indian oceans are high-risk areas. Threatened species have disproportionately high exposure risk. Outside the Mediterranean and Black seas, the high seas and Exclusive Economic Zones of the USA, Japan, and the UK have the highest exposure risk. International collaboration is crucial for addressing marine plastic impacts.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Julian M. Gaitan, Hyo Youl Moon, Matthew Stremlau, Dena B. Dubal, Dane B. Cook, Ozioma C. Okonkwo, Henriette van Praag
Summary: Research suggests that aerobic exercise training can increase plasma CTSB levels, and changes in CTSB are correlated with cognitive performance. BDNF levels decreased with exercise training, while klotho levels remained unchanged but were closely related to changes in VO(2)peak. Metabolomic analysis showed an increase in PUFAs, reductions in ceramides, sphingo- and phospholipids, as well as changes in gut microbiome metabolites and redox homeostasis with exercise training.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katherine A. Glass, Arnaud Germain, Yuhsin V. Huang, Maureen R. Hanson
Summary: The aim of this pilot study was to investigate the changes in urine metabolome between ME/CFS patients and healthy subjects following exertion. The results showed that there were no significant changes in urine metabolome of ME/CFS patients during recovery, while significant changes were observed in healthy subjects, suggesting a lack of adaptation to severe stress in ME/CFS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Meteorology & Atmospheric Sciences
Hossein Tabari, Patrick Willems
Summary: Compound hot-dry events have the potential to overwhelm natural and human systems, leading to significant damages and socioeconomic tipping points. Climate change amplifies the impacts of these events, and their future risk and role are poorly understood. By the end of the 21st century, an additional 0.7-1.7 billion people will be exposed to compound events globally, with cropland exposure increasing by 2-5.7 million km(2). Countries with weak governance will experience a larger increase in risk compared to those with good governance, highlighting the importance of effective governance in managing and mitigating compound events.
NPJ CLIMATE AND ATMOSPHERIC SCIENCE
(2023)
Article
Critical Care Medicine
Lindsay M. Forbes, Todd M. Bull, Tim Lahm, Barry J. Make, William K. Cornwell III
Summary: Right ventricular dysfunction in pulmonary hypertension has negative implications for exercise capacity, morbidity, and mortality. During exercise, right ventricular afterload may increase disproportionately, impairing right ventricular contractility and limiting cardiac output. Abnormal pulmonary vascular response to exercise can signal early disease and increased mortality. Exercise testing can evaluate pulmonary vascular response and right ventricular contractile reserve. More research is needed to determine the role of exercise stress testing in the management of pulmonary vascular disease.
Article
Medicine, General & Internal
Christina Magnussen, Francisco M. Ojeda, Darryl P. Leong, Jesus Alegre-Diaz, Philippe Amouyel, Larissa Aviles-Santa, Dirk De Bacquer, Christie M. Ballantyne, Antonio Bernabe-Ortiz, Martin Bobak, Hermann Brenner, Rodrigo M. Carrillo-Larco, James de Lemos, Annette Dobson, Marcus Dorr, Chiara Donfrancesco, Wojciech Drygas, Robin P. Dullaart, Gunnar Engstrom, Marco M. Ferrario, Jean Ferrieres, Giovanni de Gaetano, Uri Goldbourt, Clicerio Gonzalez, Guido Grassi, Allison M. Hodge, Kristian Hveem, Licia Iacoviello, M. Kamran Ikram, Vilma Irazola, Modou Jobe, Pekka Jousilahti, Pontiano Kaleebu, Maryam Kavousi, Frank Kee, Davood Khalili, Wolfgang Koenig, Anna Kontsevaya, Kari Kuulasmaa, Karl J. Lackner, David M. Leistner, Lars Lind, Allan Linneberg, Thiess Lorenz, Magnus Nakrem Lyngbakken, Reza Malekzadeh, Sofia Malyutina, Ellisiv B. Mathiesen, Olle Melander, Andres Metspalu, J. Jaime Miranda, Marie Moitry, Joseph Mugisha, Mahdi Nalini, Vijay Nambi, Toshiharu Ninomiya, Karen Oppermann, Eleonora d'Orsi, Andrzej Pajak, Luigi Palmieri, Demosthenes Panagiotakos, Arokiasamy Perianayagam, Annette Peters, Hossein Poustchi, Andrew M. Prentice, Eva Prescott, Ulf Riserus, Veikko Salomaa, Susana Sans, Satoko Sakata, Ben Schottker, Aletta E. Schutte, Sadaf G. Sepanlou, Sanjib Kumar Sharma, Jonathan E. Shaw, Leon A. Simons, Stefan Soderberg, Abdonas Tamosiunas, Barbara Thorand, Hugh Tunstall-Pedoe, Raphael Twerenbold, Diego Vanuzzo, Giovanni Veronesi, Julia Waibel, S. Goya Wannamethee, Masafumi Watanabe, Philipp S. Wild, Yao Yao, Yi Zeng, Andreas Ziegler, Stefan Blankenberg
Summary: This study provides evidence that five modifiable risk factors are associated with cardiovascular disease and death, and their prevalence varies by geographic region and sex.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Yash R. Patel, Jeremy M. Robbins, Katherine E. Kurgansky, Tasnim Imran, Ariela R. Orkaby, Robert R. McLean, Yuk-Lam Ho, Kelly Cho, J. Michael Gaziano, Luc Djousse, David R. Gagnon, Jacob Joseph
BMC CARDIOVASCULAR DISORDERS
(2018)
Article
Cardiac & Cardiovascular Systems
Jeremy M. Robbins, Matthew Herzig, Jordan Morningstar, Mark A. Sarzynski, Daniel E. Cruz, Thomas J. Wang, Yan Gao, James G. Wilson, Claude Bouchard, Tuomo Rankinen, Robert E. Gerszten
Article
Endocrinology & Metabolism
Zsu-Zsu Chen, Jinxi Liu, Jordan Morningstar, Brandy M. Heckman-Stoddard, Christine G. Lee, Samuel Dagogo-Jack, Jane F. Ferguson, Richard F. Hamman, William C. Knowler, Kieren J. Mather, Leigh Perreault, Jose C. Florez, Thomas J. Wang, Clary Clish, Marinella Temprosa, Robert E. Gerszten
Article
Biochemistry & Molecular Biology
Jocelyn R. Farmer, Hugues Allard-Chamard, Na Sun, Maimuna Ahmad, Alice Bertocchi, Vinay S. Mahajan, Toby Aicher, Johan Arnold, Mark D. Benson, Jordan Morningstar, Sara Barmettler, Grace Yuen, Samuel J. H. Murphy, Jolan E. Walter, Musie Ghebremichael, Alex K. Shalek, Facundo Batista, Robert Gerszten, Shiv Pillai
Editorial Material
Gastroenterology & Hepatology
Jordan E. Morningstar, Wing-Kin Syn, Sheldon E. Litwin
DIGESTIVE DISEASES AND SCIENCES
(2020)
Article
Nutrition & Dietetics
Yash R. Patel, Jeremy M. Robbins, J. Michael Gaziano, Luc Djousse
Summary: The study showed that Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Alternate Healthy Eating Index (AHEI) diets were inversely associated with total mortality. Specifically, the Mediterranean and AHEI scores were associated with a lower risk of cardiovascular disease mortality, while AHEI and Mediterranean scores were associated with a lower risk of cancer mortality.
Article
Cardiac & Cardiovascular Systems
Daniel H. Katz, Usman A. Tahir, Alexander G. Bick, Akhil Pampana, Debby Ngo, Mark D. Benson, Zhi Yu, Jeremy M. Robbins, Zsu-Zsu Chen, Daniel E. Cruz, Shuliang Deng, Laurie Farrell, Sumita Sinha, Alec A. Schmaier, Dongxiao Shen, Yan Gao, Michael E. Hall, Adolfo Correa, Russell P. Tracy, Peter Durda, Kent D. Taylor, Yongmei Liu, W. Craig Johnson, Xiuqing Guo, Jie Yao, Yii-Der Ida Chen, Ani W. Manichaikul, Deepti Jain, Claude Bouchard, Mark A. Sarzynski, Stephen S. Rich, Jerome I. Rotter, Thomas J. Wang, James G. Wilson, Pradeep Natarajan, Robert E. Gerszten
Summary: This study used whole genome sequencing to analyze the plasma proteome in individuals with greater African ancestry, identifying novel genetic determinants of cardiovascular diseases and uncovering new biological mechanisms specific to African ancestry.
Editorial Material
Cardiac & Cardiovascular Systems
Jennifer E. Ho, Jeremy M. Robbins
Summary: The staging classification of heart failure aims to highlight disease progression and the potential for early prevention. Currently, the role of exercise training in high-risk patients with early stage heart failure is unclear. Previous studies have shown links between obesity, cardiometabolic disease, physical inactivity, and heart failure risk, particularly for HF with preserved ejection fraction. Modifiable lifestyle efforts, including increased physical activity, weight loss, and regular exercise, may play a crucial role in the prevention and treatment of HFpEF, given the lack of effective pharmacotherapies.
JACC-HEART FAILURE
(2022)
Article
Multidisciplinary Sciences
Daniel H. Katz, Jeremy M. Robbins, Shuliang Deng, Usman A. Tahir, Alexander G. Bick, Akhil Pampana, Zhi Yu, Debby Ngo, Mark D. Benson, Zsu-Zsu Chen, Daniel E. Cruz, Dongxiao Shen, Yan Gao, Claude Bouchard, Mark A. Sarzynski, Adolfo Correa, Pradeep Natarajan, James G. Wilson, Robert E. Gerszten
Summary: This study compared the performance of three proteomic profiling techniques, SomaScan1.3K, SomaScan5K, and Olink Explore, in terms of precision, accuracy, analytic breadth, and phenotypic associations. The results showed that Olink platform had more reliable protein target specificity and a higher number of phenotypic associations, while Soma platforms had greater measurement precision and analytic breadth across the proteome.
Article
Medicine, Research & Experimental
Jeremy M. Robbins, Prashant Rao, Shuliang Deng, Michelle J. Keyes, Usman A. Tahir, Daniel H. Katz, Pierre M. Jean Beltran, Francois Marchildon, Jacob L. Barber, Bennet Peterson, Yan Gao, Adolfo Correa, James G. Wilson, J. Gustav Smith, Paul Cohen, Robert Ross, Claude Bouchard, Mark A. Sarzynski, Robert E. Gerszten
Summary: Regular exercise leads to beneficial effects on health, and this study aims to investigate the proteomic changes that occur in the plasma after regular exercise. The researchers conducted a large-scale analysis on 654 healthy individuals before and after a 20-week endurance exercise training. They identified numerous circulating proteins that are modulated, highlighting proteins involved in angiogenesis, iron homeostasis, and the extracellular matrix, including a novel increase in fibroblast activation protein (FAP) related to body composition homeostasis.
Correction
Endocrinology & Metabolism
Jeremy M. Robbins, Bennet Peterson, Daniela Schranner, Usman A. Tahir, Theresa Rienmuller, Shuliang Deng, Michelle J. Keyes, Daniel H. Katz, Pierre M. Jean Beltran, Jacob L. Barber, Christian Baumgartner, Steven A. Carr, Sujoy Ghosh, Changyu Shen, Lori L. Jennings, Robert Ross, Mark A. Sarzynski, Claude Bouchard, Robert E. Gerszten
Article
Endocrinology & Metabolism
Jeremy M. Robbins, Bennet Peterson, Daniela Schranner, Usman A. Tahir, Theresa Rienmueller, Shuliang Deng, Michelle J. Keyes, Daniel H. Katz, Pierre M. Jean Beltran, Jacob L. Barber, Christian Baumgartner, Steven A. Carr, Sujoy Ghosh, Changyu Shen, Lori L. Jennings, Robert Ross, Mark A. Sarzynski, Claude Bouchard, Robert E. Gerszten
Summary: The study analyzed plasma protein levels and identified proteins associated with individual oxygen consumption and increase in oxygen consumption after exercise training, which improved the prediction of individual oxygen consumption. The findings were validated in separate exercise cohorts and linked some proteins to all-cause mortality in a community-based cohort. The study also reproduced the specificity of key findings using antibody-based assays.
Article
Medicine, Research & Experimental
Soravis Osataphan, Chiara Macchi, Garima Singhal, Jeremy Chimene-Weiss, Vicencia Sales, Chisayo Kozuka, Jonathan M. Dreyfuss, Hui Pan, Yanin Tangcharoenpaisan, Jordan Morningstar, Robert Gerszten, Mary-Elizabeth Patti
Article
Biochemistry & Molecular Biology
Jordan Morningstar, Jangwoen Lee, Tara Hendry-Hofer, Alyssa Witeof, Tiffany Lyle, Gregg Knipp, Calum A. MacRae, Gerry R. Boss, Randall T. Peterson, Vincent J. Davisson, Robert E. Gerszten, Vikhyat S. Bebarta, Sari Mahon, Matt Brenner, Anjali K. Nath
