Induction of metabolic quiescence defines the transitional to follicular B cell switch

Germline-activating mutations inPIK3CDcompromise B cell development and function

(2018) Danielle T. Avery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Second signals rescue B cells from activation-induced mitochondrial dysfunction and death

(2018) Munir Akkaya et al.   NATURE IMMUNOLOGY

Common Variable Immunodeficiency Non-Infectious Disease Endotypes Redefined Using Unbiased Network Clustering in Large Electronic Datasets

(2018) Jocelyn R. Farmer et al.   Frontiers in Immunology

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

(2018) Anne-Katrien Stark et al.   Nature Communications

Novel PIK3CD mutations affecting N-terminal residues of p110δ cause activated PI3Kδ syndrome (APDS) in humans

(2017) Andrew J. Takeda et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study

(2017) Tanya I. Coulter et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4

(2017) Yeonwoo Park et al.   Cell Reports

Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination

(2016) Robert K. Abbott et al.   JOURNAL OF IMMUNOLOGY

Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system

(2016) Sung Hoon Cho et al.   NATURE

Expansion of the Gene Ontology knowledgebase and resources

(2016)   NUCLEIC ACIDS RESEARCH

A comparison of human and mouse gene co-expression networks reveals conservation and divergence at the tissue, pathway and disease levels

(2015) Gianni Monaco et al.   BMC EVOLUTIONARY BIOLOGY

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Transcription factors regulating B cell fate in the germinal centre

(2015) T. Recaldin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones

(2015) Sandrine Sander et al.   IMMUNITY

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus

(2015) Christopher M Tipton et al.   NATURE IMMUNOLOGY

TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation

(2015) Xinxin Ci et al.   PLoS One

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Identification of a human splenic marginal zone B cell precursor with NOTCH2-dependent differentiation properties

(2014) Marc Descatoire et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Purinergic signalling and immune cells

(2014) Geoffrey Burnstock et al.   Purinergic Signalling

mTORC1 signaling controls multiple steps in ribosome biogenesis

(2014) Valentina Iadevaia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experiments

(2013) Ning Leng et al.   BIOINFORMATICS

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

(2013) Carrie L Lucas et al.   NATURE IMMUNOLOGY

Smart-seq2 for sensitive full-length transcriptome profiling in single cells

(2013) Simone Picelli et al.   NATURE METHODS

Phosphoinositide 3-Kinase   Gene Mutation Predisposes to Respiratory Infection and Airway Damage

(2013) I. Angulo et al.   SCIENCE

Dependence of Immunoglobulin Class Switch Recombination in B Cells on Vesicular Release of ATP and CD73 Ectonucleotidase Activity

(2013) Francesca Schena et al.   Cell Reports

The establishment of early B cell tolerance in humans: lessons from primary immunodeficiency diseases

(2012) Eric Meffre   Annals of the New York Academy of Sciences

ABCA1 increases extracellular ATP to mediate cholesterol efflux to ApoA-I

(2011) Jee Yeon Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Direct activation of mTOR in B lymphocytes confers impairment in B-cell maturation andloss of marginal zone B cells

(2011) Sandrine Benhamron et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Foxo1 regulates marginal zone B-cell development

(2010) Jing Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Novel Human Transitional B Cell Populations Revealed by B Cell Depletion Therapy

(2009) Arumugam Palanichamy et al.   JOURNAL OF IMMUNOLOGY

Direct control of mitochondrial function by mTOR

(2009) Arvind Ramanathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression

(2008) Carolyn L. Buller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes.

(2008) X. M. Luo et al.   BLOOD

Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

(2008) Hart S Dengler et al.   NATURE IMMUNOLOGY