Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional

DNA damage-induced S phase arrest in human breast cancer depends on Chk1, but G2arrest can occur independently of Chk1, Chk2 or MAPKAPK2

(2011) Wen-Hui Zhang et al.   CELL CYCLE

14-3-3σ and p21 synergize to determine DNA damage response following Chk2 inhibition

(2011) Shasha Meng et al.   CELL CYCLE

p21Cip1/WAF1mediates cyclin B1 degradation in response to DNA damage

(2011) Laura D. Gillis et al.   CELL CYCLE

Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy

(2010) Teresa Davoli et al.   CELL

Targeting the checkpoint kinase Chk1 in cancer therapy

(2010) Callie Merry et al.   CELL CYCLE

Cell cycle re-entry mechanisms after DNA damage checkpoints: Giving it some gas to shut off the breaks!

(2010) Marcel A.T.M. van Vugt et al.   CELL CYCLE

New Insights into Checkpoint Kinase 1 in the DNA Damage Response Signaling Network

(2010) Y. Dai et al.   CLINICAL CANCER RESEARCH

Activation of cyclin B1–Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis

(2010) Olivier Gavet et al.   JOURNAL OF CELL BIOLOGY

Role of ATM and the Damage Response Mediator Proteins 53BP1 and MDC1 in the Maintenance of G2/M Checkpoint Arrest

(2010) A. Shibata et al.   MOLECULAR AND CELLULAR BIOLOGY

A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint

(2010) Marcel A. T. M. van Vugt et al.   PLOS BIOLOGY

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2

(2009) H Christian Reinhardt et al.   CURRENT OPINION IN CELL BIOLOGY

Tumor protein 53 mutations and inherited cancer: beyond Li-Fraumeni syndrome

(2009) Edenir I Palmero et al.   CURRENT OPINION IN ONCOLOGY

Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells

(2009) Nozomi Tomimatsu et al.   EMBO REPORTS

DNA Damage Triggers p21WAF1-dependent Emi1 Down-Regulation That Maintains G2 Arrest

(2009) Jinho Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct mechanisms act in concert to mediate cell cycle arrest

(2009) Jared E. Toettcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Posttranslational Modification of p53: Cooperative Integrators of Function

(2009) D. W. Meek et al.   Cold Spring Harbor Perspectives in Biology

DNA Protein Kinase Dependent G2 Checkpoint Revealed following Knockdown of Ataxia-Telangiectasia Mutated in Human Mammary Epithelial Cells

(2008) S. J.H. Arlander et al.   CANCER RESEARCH

Chk1 Is a Histone H3 Threonine 11 Kinase that Regulates DNA Damage-Induced Transcriptional Repression

(2008) Midori Shimada et al.   CELL

Differential Roles for Checkpoint Kinases in DNA Damage-dependent Degradation of the Cdc25A Protein Phosphatase

(2008) Jianping Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

(2008) Martin F. Lavin   NATURE REVIEWS MOLECULAR CELL BIOLOGY