Reduced Cell-Associated DNA and Improved Viral Control in Macaques following Passive Transfer of a Single Anti-V2 Monoclonal Antibody and Repeated Simian/Human Immunodeficiency Virus Challenges

Use of broadly neutralizing antibodies for HIV-1 prevention

(2017) Amarendra Pegu et al.   IMMUNOLOGICAL REVIEWS

Monoclonal Antibodies Specific for the V2, V3, CD4-Binding Site, and gp41 of HIV-1 Mediate Phagocytosis in a Dose-Dependent Manner

(2017) Thomas Musich et al.   JOURNAL OF VIROLOGY

Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer

(2017) Yuhang Liu et al.   JOURNAL OF VIROLOGY

Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

(2017) Marina Caskey et al.   NATURE MEDICINE

Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection

(2017) Geetha H. Mylvaganam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

(2017) Ling Xu et al.   SCIENCE

Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge

(2017) Boris Julg et al.   Science Translational Medicine

Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies

(2017) Constantinos Petrovas et al.   Science Translational Medicine

Non-neutralizing Antibodies Targeting the V1V2 Domain of HIV Exhibit Strong Antibody-Dependent Cell-mediated Cytotoxic Activity

(2017) Luzia M. Mayr et al.   Scientific Reports

Neutralizing antibody affords comparable protection against vaginal and rectal simian/human immunodeficiency virus challenge in macaques

(2016) Brian Moldt et al.   AIDS

Multiple Origins of Virus Persistence during Natural Control of HIV Infection

(2016) Eli A. Boritz et al.   CELL

Rationally Designed Vaccines Targeting the V2 Region of HIV-1 gp120 Induce a Focused, Cross-Clade-Reactive, Biologically Functional Antibody Response

(2016) Susan Zolla-Pazner et al.   JOURNAL OF VIROLOGY

Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition

(2016) Monica Vaccari et al.   NATURE MEDICINE

Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques

(2016) Ann J Hessell et al.   NATURE MEDICINE

Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus

(2016) Jinyan Liu et al.   SCIENCE

In Vivo HIV-1 Cell-to-Cell Transmission Promotes Multicopy Micro-compartmentalized Infection

(2016) Kenneth M. Law et al.   Cell Reports

Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort

(2016) Elise Landais et al.   PLoS Pathogens

Modeling Viral Spread

(2016) Frederik Graw et al.   Annual Review of Virology

The V1V2 Region of HIV-1 gp120 Forms a Five-Stranded Beta Barrel

(2015) Ruimin Pan et al.   JOURNAL OF VIROLOGY

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

(2015) Yoshinori Fukazawa et al.   NATURE MEDICINE

Mucosal B Cells Are Associated with Delayed SIV Acquisition in Vaccinated Female but Not Male Rhesus Macaques Following SIVmac251 Rectal Challenge

(2015) Iskra Tuero et al.   PLoS Pathogens

Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques

(2015) Sampa Santra et al.   PLoS Pathogens

Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity

(2014) Stylianos Bournazos et al.   CELL

Cytomegalovirus pp65 limits dissemination but is dispensable for persistence

(2014) Daniel Malouli et al.   JOURNAL OF CLINICAL INVESTIGATION

Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques

(2014) Masashi Shingai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of in vitro antibody-dependent cell-mediated cytotoxicity activity of therapeutic antibodies — Impact of effector cells

(2014) Shan Chung et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Envelope Variants Circulating as Initial Neutralization Breadth Developed in Two HIV-Infected Subjects Stimulate Multiclade Neutralizing Antibodies in Rabbits

(2014) D. C. Malherbe et al.   JOURNAL OF VIROLOGY

HIV-1 Vaccine-Induced C1 and V2 Env-Specific Antibodies Synergize for Increased Antiviral Activities

(2014) Justin Pollara et al.   JOURNAL OF VIROLOGY

Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo

(2014) R. S. Rudicell et al.   JOURNAL OF VIROLOGY

Vaccine-Induced IgG Antibodies to V1V2 Regions of Multiple HIV-1 Subtypes Correlate with Decreased Risk of HIV-1 Infection

(2014) Susan Zolla-Pazner et al.   PLoS One

Lack of Protection following Passive Transfer of Polyclonal Highly Functional Low-Dose Non-Neutralizing Antibodies

(2014) Anne-Sophie Dugast et al.   PLoS One

Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor

(2014) A. Pegu et al.   Science Translational Medicine

Vaccine-Induced Env V1-V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination

(2014) N. L. Yates et al.   Science Translational Medicine

Fc Receptor-Mediated Immune Responses: New Tools But Increased Complexity in HIV Prevention

(2013) Diego Vargas-Inchaustegui et al.   CURRENT HIV RESEARCH

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

(2013) Hua-Xin Liao et al.   IMMUNITY

Protective effect of vaginal application of neutralizing and nonneutralizing inhibitory antibodies against vaginal SHIV challenge in macaques

(2013) C Moog et al.   Mucosal Immunology

Immune clearance of highly pathogenic SIV infection

(2013) Scott G. Hansen et al.   NATURE

Analysis of V2 Antibody Responses Induced in Vaccinees in the ALVAC/AIDSVAX HIV-1 Vaccine Efficacy Trial

(2013) Susan Zolla-Pazner et al.   PLoS One

Epitope Mapping of Conformational V2-specific Anti-HIV Human Monoclonal Antibodies Reveals an Immunodominant Site in V2

(2013) Luzia M. Mayr et al.   PLoS One

Plasma IgG to Linear Epitopes in the V2 and V3 Regions of HIV-1 gp120 Correlate with a Reduced Risk of Infection in the RV144 Vaccine Efficacy Trial

(2013) Raphael Gottardo et al.   PLoS One

A Novel Assay for Antibody-Dependent Cell-Mediated Cytotoxicity against HIV-1- or SIV-Infected Cells Reveals Incomplete Overlap with Antibodies Measured by Neutralization and Binding Assays

(2012) M. D. Alpert et al.   JOURNAL OF VIROLOGY

Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2

(2012) Morgane Rolland et al.   NATURE

Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys

(2012) Dan H. Barouch et al.   NATURE

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo

(2012) B. Moldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional and immunochemical cross-reactivity of V2-specific monoclonal antibodies from HIV-1-infected individuals

(2012) Miroslaw K. Gorny et al.   VIROLOGY

ADCC Develops Over Time during Persistent Infection with Live-Attenuated SIV and Is Associated with Complete Protection against SIVmac251 Challenge

(2012) Michael D. Alpert et al.   PLoS Pathogens

Cell-Cell Transmission Enables HIV-1 to Evade Inhibition by Potent CD4bs Directed Antibodies

(2012) Irene A. Abela et al.   PLoS Pathogens

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

(2011) Jason S. McLellan et al.   NATURE

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody

(2011) D. R. Burton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccine-elicited SIV and HIV envelope-specific IgA and IgG memory B cells in rhesus macaque peripheral blood correlate with functional antibody responses and reduced viremia

(2011) Egidio Brocca-Cofano et al.   VACCINE

Neutralizing Antibody Titers Conferring Protection to Macaques from a Simian/Human Immunodeficiency Virus Challenge Using the TZM-bl Assay

(2010) Ronald Willey et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples

(2010) Margaret E. Ackerman et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Relative Transmissibility of an R5 Clade C Simian‐Human Immunodeficiency Virus Across Different Mucosae in Macaques Parallels the Relative Risks of Sexual HIV‐1 Transmission in Humans via Different Routes

(2010) Agnès L. Chenine et al.   JOURNAL OF INFECTIOUS DISEASES

Multiple Vaccine-Elicited Nonneutralizing Antienvelope Antibody Activities Contribute to Protective Efficacy by Reducing both Acute and Chronic Viremia following Simian/Human Immunodeficiency Virus SHIV89.6P Challenge in Rhesus Macaques

(2010) P. Xiao et al.   JOURNAL OF VIROLOGY

B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection

(2010) Kuan-Hsiang G. Huang et al.   Nature Communications

Contribution of Nonneutralizing Vaccine-Elicited Antibody Activities to Improved Protective Efficacy in Rhesus Macaques Immunized with Tat/Env Compared with Multigenic Vaccines

(2009) R. H. Florese et al.   JOURNAL OF IMMUNOLOGY

Viral Sanctuaries during Highly Active Antiretroviral Therapy in a Nonhuman Primate Model for AIDS

(2009) T. W. North et al.   JOURNAL OF VIROLOGY

Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques

(2009) Ann J Hessell et al.   NATURE MEDICINE

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Visualizing Antigen-Specific and Infected Cells in Situ Predicts Outcomes in Early Viral Infection

(2009) Q. Li et al.   SCIENCE

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

Correlation of Vaccine-Elicited Systemic and Mucosal Nonneutralizing Antibody Activities with Reduced Acute Viremia following Intrarectal Simian Immunodeficiency Virus SIVmac251 Challenge of Rhesus Macaques

(2008) R. Hidajat et al.   JOURNAL OF VIROLOGY