Mxd1 mediates hypoxia-induced cisplatin resistance in osteosarcoma cells by repression of the PTEN tumor suppressor gene

New Treatment Options for Osteosarcoma – Inactivation of Osteosarcoma Cells by Cold Atmospheric Plasma

(2016) DENIS GÜMBEL et al.   ANTICANCER RESEARCH

Hypoxia promotes chemoresistance in acute lymphoblastic leukemia cell lines by modulating death signaling pathways

(2016) C. Petit et al.   BMC CANCER

Hypoxia-induced modulation of PTEN activity and EMT phenotypes in lung cancers

(2016) Takashi Kohnoh et al.   Cancer Cell International

Hypoxia-induced resistance to cisplatin-mediated apoptosis in osteosarcoma cells is reversed by gambogic acid independently of HIF-1α

(2016) Wei Zhao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Update on Survival in Osteosarcoma

(2016) Megan E. Anderson   ORTHOPEDIC CLINICS OF NORTH AMERICA

MicroRNA-421 regulated by HIF-1α promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer

(2016) Xiaoxiao Ge et al.   Oncotarget

Down regulation of miR-202 modulates Mxd1 and Sin3A repressor complexes to induce apoptosis of pancreatic cancer cells

(2015) Lulu Farhana et al.   CANCER BIOLOGY & THERAPY

Berberine Sensitizes Human Ovarian Cancer Cells to Cisplatin Through miR-93/PTEN/Akt Signaling Pathway

(2015) Qiaoyun Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Phosphatase and Tensin Homolog (PTEN) Represses Colon Cancer Progression through Inhibiting Paxillin Transcription via PI3K/AKT/NF-κB Pathway

(2015) Ling-Li Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteosarcoma: Current Treatment and a Collaborative Pathway to Success

(2015) Michael S. Isakoff et al.   JOURNAL OF CLINICAL ONCOLOGY

microRNA-93 promotes cell proliferation via targeting of PTEN in Osteosarcoma cells

(2015) Masanori Kawano et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Osteosarcoma: better treatment through better trial design

(2015) Robert S Benjamin   LANCET ONCOLOGY

Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1α destabilization

(2015) Carina Fischer et al.   Molecular Cancer

Hypoxia upregulates Rab11-family interacting protein 4 through HIF-1α to promote the metastasis of hepatocellular carcinoma

(2015) F Hu et al.   ONCOGENE

PTEN and PI3K/AKT in non-small-cell lung cancer

(2015) Cristina Pérez-Ramírez et al.   PHARMACOGENOMICS

MicroRNA-221 targets PTEN to reduce the sensitivity of cervical cancer cells to gefitinib through the PI3K/Akt signaling pathway

(2015) Juan Du et al.   TUMOR BIOLOGY

RY-2f, an isoflavone analog, overcomes cisplatin resistance to inhibit ovarian tumorigenesis via targeting the PI3K/AKT/mTOR signaling pathway

(2015) Mingming Liu et al.   Oncotarget

MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway

(2015) Changjun He et al.   Oncotarget

PTEN overexpression improves cisplatin-resistance of human ovarian cancer cells through upregulating KRT10 expression

(2014) Huijuan Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PTEN inhibits the invasion and metastasis of gastric cancer via downregulation of FAK expression

(2014) Ling-Li Zhang et al.   CELLULAR SIGNALLING

Resveratrol abrogates the effects of hypoxia on cell proliferation, invasion and EMT in osteosarcoma cells through downregulation of the HIF-1α protein

(2014) YONGMING SUN et al.   Molecular Medicine Reports

Downregulation of galectin-3 causes a decrease in uPAR levels and inhibits the proliferation, migration and invasion of hepatocellular carcinoma cells

(2014) DATONG ZHENG et al.   ONCOLOGY REPORTS

Effect of the PTEN gene on adhesion, invasion and metastasis of osteosarcoma cells

(2014) YONG HU et al.   ONCOLOGY REPORTS

MiR-19a/b modulate the metastasis of gastric cancer cells by targeting the tumour suppressor MXD1

(2014) Q Wu et al.   Cell Death & Disease

Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance

(2013) Mohan Singh et al.   BMC CANCER

SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non-Small Cell Lung Cancers to Cisplatin and Doxorubicin

(2013) D. H. Shin et al.   CANCER RESEARCH

Mad1 mediates hypoxia-induced doxorubicin resistance in colon cancer cells by inhibiting mitochondrial function

(2013) Kumsun Cho et al.   FREE RADICAL BIOLOGY AND MEDICINE

miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN

(2013) Shou-mei Yang et al.   TOXICOLOGY

Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors

(2012) Xia Ke et al.   CARCINOGENESIS

Downregulation of galectin-3 by EGF mediates the apoptosis of HepG2 cells

(2012) Zhenzhen Hu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Vitamin D receptor as a master regulator of the c-MYC/MXD1 network

(2012) R. Salehi-Tabar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF-1  Mediates Tumor Hypoxia to Confer a Perpetual Mesenchymal Phenotype for Malignant Progression

(2011) Y.-G. Yoo et al.   Science Signaling

The proliferation, apoptosis, invasion of endothelial-like epithelial ovarian cancer cells induced by hypoxia

(2010) Pengfei Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Involvement of the PTEN–AKT–FOXO3a Pathway in Neuronal Apoptosis in Developing Rat Brain after Hypoxia–Ischemia

(2009) Deyuan Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1

(2008) J. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of apoptosis by MAD1 is mediated by repression of the PTEN tumor suppressor gene

(2007) Sabine Rottmann et al.   FASEB JOURNAL