The double life of KLF5: Opposing roles in regulation of gene-expression, cellular function, and transformation

Methylation ofKLF5contributes to reduced expression in acute myeloid leukaemia and is associated with poor overall survival

(2013) Sonya M. Diakiw et al.   BRITISH JOURNAL OF HAEMATOLOGY

Different Expression Patterns and Functions of Acetylated and Unacetylated Klf5 in the Proliferation and Differentiation of Prostatic Epithelial Cells

(2013) Changsheng Xing et al.   PLoS One

Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking

(2013) E. Taniguchi Ishikawa et al.   Nature Communications

YAP Promotes Breast Cell Proliferation and Survival Partially through Stabilizing the KLF5 Transcription Factor

(2012) Xu Zhi et al.   AMERICAN JOURNAL OF PATHOLOGY

RAS signalling in the colorectum in health and disease

(2012) George Poulogiannis et al.   CELL COMMUNICATION AND ADHESION

p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation

(2012) Yizeng Yang et al.   CELL CYCLE

KLF5 and hhLIM cooperatively promote proliferation of vascular smooth muscle cells

(2012) Hui-jing Shi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Krüppel-Like Factor 5 Protects against Murine Colitis and Activates JAK-STAT Signaling In Vivo

(2012) Marie-Pier Tetreault et al.   PLoS One

Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells

(2011) Ke-Wen Zhao et al.   BIOCHEMICAL JOURNAL

Loss of Transcription Factor KLF5 in the Context of p53 Ablation Drives Invasive Progression of Human Squamous Cell Cancer

(2011) Y. Yang et al.   CANCER RESEARCH

TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis

(2011) Dong Zhao et al.   CARCINOGENESIS

HDAC2 phosphorylation-dependent Klf5 deacetylation and RARα acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs

(2011) Bin Zheng et al.   CELL RESEARCH

Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells

(2011) Doreswamy Kenchegowda et al.   DEVELOPMENTAL BIOLOGY

Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium

(2011) Sheila M. Bell et al.   DEVELOPMENTAL BIOLOGY

Krüppel-Like Factor 5 Is Important for Maintenance of Crypt Architecture and Barrier Function in Mouse Intestine

(2011) Beth B. McConnell et al.   GASTROENTEROLOGY

The E3 Ubiquitin Ligase SMAD Ubiquitination Regulatory Factor 2 Negatively Regulates Krüppel-like Factor 5 Protein

(2011) James X. Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Renal collecting duct epithelial cells regulate inflammation in tubulointerstitial damage in mice

(2011) Katsuhito Fujiu et al.   JOURNAL OF CLINICAL INVESTIGATION

Deregulated expression of Kruppel-like factors in acute myeloid leukemia

(2011) Magali Humbert et al.   LEUKEMIA RESEARCH

The granulocyte-associated transcription factor Krüppel-like factor 5 is silenced by hypermethylation in acute myeloid leukemia

(2011) Sonya M. Diakiw et al.   LEUKEMIA RESEARCH

The Induction of KLF5 Transcription Factor by Progesterone Contributes to Progesterone-Induced Breast Cancer Cell Proliferation and Dedifferentiation

(2011) Rong Liu et al.   MOLECULAR ENDOCRINOLOGY

Overexpression of angiotensin II type 2 receptor suppresses neointimal hyperplasia in a rat carotid arterial balloon injury model

(2011) Li   Molecular Medicine Reports

Association of Expression of Kruppel-Like Factor 4 and Kruppel-Like Factor 5 with the Clinical Manifestations of Breast Cancer

(2011) Chih-Jung Chen et al.   PATHOLOGY & ONCOLOGY RESEARCH

Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF)

(2011) C. Mas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estrogen Regulates Tumor Growth Through a Nonclassical Pathway that Includes the Transcription Factors ER  and KLF5

(2011) Y. Nakajima et al.   Science Signaling

Krüppel-Like Factor 5 Is Not Required for K-RasG12D Lung Tumorigenesis, but Represses ABCG2 Expression and Is Associated with Better Disease-Specific Survival

(2010) Sara E. Meyer et al.   AMERICAN JOURNAL OF PATHOLOGY

Phenotypic Modulation of Vascular Smooth Muscle Cells

(2010) RYOZO NAGAI et al.   Annals of the New York Academy of Sciences

Direct targets of Klf5 transcription factor contribute to the maintenance of mouse embryonic stem cell undifferentiated state

(2010) Silvia Parisi et al.   BMC BIOLOGY

Krüppel-like transcription factors and control of pluripotency

(2010) Pierre-Yves Bourillot et al.   BMC BIOLOGY

The Fbw7 Tumor Suppressor Targets KLF5 for Ubiquitin-Mediated Degradation and Suppresses Breast Cell Proliferation

(2010) Dong Zhao et al.   CANCER RESEARCH

Krüppel-Like Factor 5 Protects Against Dextran Sulfate Sodium−Induced Colonic Injury in Mice by Promoting Epithelial Repair

(2010) Beth B. McConnell et al.   GASTROENTEROLOGY

The Fbw7/Human CDC4 Tumor Suppressor Targets Proproliferative Factor KLF5 for Ubiquitination and Degradation through Multiple Phosphodegron Motifs

(2010) Ning Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations

(2010) Mandayam O Nandan et al.   Molecular Cancer

Mammalian Krüppel-Like Factors in Health and Diseases

(2010) Beth B. McConnell et al.   PHYSIOLOGICAL REVIEWS

Krüppel-like factor (KLF) 5 mediates cyclin D1 expression and cell proliferation via interaction with c-Jun in Ang II-induced VSMCs

(2009) Yu Liu et al.   ACTA PHARMACOLOGICA SINICA

Haploinsufficiency of Kruppel-Like Factor 5 Rescues the Tumor-Initiating Effect of the ApcMin Mutation in the Intestine

(2009) B. B. McConnell et al.   CANCER RESEARCH

Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases

(2009) Jin-Tang Dong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Synthetic retinoid Am80 inhibits interaction of KLF5 with RARα through inducing KLF5 dephosphorylation mediated by the PI3K/Akt signaling in vascular smooth muscle cells

(2009) Xin-hua Zhang et al.   FEBS LETTERS

Estrogen-induced interaction between KLF5 and estrogen receptor (ER) suppresses the function of ER in ER-positive breast cancer cells

(2009) Peng Guo et al.   INTERNATIONAL JOURNAL OF CANCER

Angiotensin II Stimulates KLF5 Phosphorylation and its Interaction with c-Jun Leading to Suppression of p21 Expression in Vascular Smooth Muscle Cells

(2009) M. He et al.   JOURNAL OF BIOCHEMISTRY

KLF5 Promotes Breast Cell Survival Partially through Fibroblast Growth Factor-binding Protein 1-pERK-mediated Dual Specificity MKP-1 Protein Phosphorylation and Stabilization

(2009) Rong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation of KLF5 Alters the Assembly of p15 Transcription Factors in Transforming Growth Factor-β-mediated Induction in Epithelial Cells

(2009) Peng Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Opposing Effects of KLF5 on the Transcription ofMYCin Epithelial Proliferation in the Context of Transforming Growth Factor β

(2009) Peng Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Krüppel-like Factor 5 Shows Proliferation-specific Roles in Vascular Remodeling, Direct Stimulation of Cell Growth, and Inhibition of Apoptosis

(2009) Toru Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Up-Regulation of Kruppel-Like Factor 5 in Pancreatic Cancer Is Promoted by Interleukin-1  Signaling and Hypoxia-Inducible Factor-1 

(2009) A. Mori et al.   MOLECULAR CANCER RESEARCH

Induction of Krüppel-Like Factor 5 Expression by Androgens Results in Increased CXCR4-Dependent Migration of Prostate Cancer Cellsin Vitro

(2009) Daniel E. Frigo et al.   MOLECULAR ENDOCRINOLOGY

Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1

(2009) H -Q Zheng et al.   ONCOGENE

KLF5 enhances SREBP-1 action in androgen-dependent induction of fatty acid synthase in prostate cancer cells

(2008) Min-Young Lee et al.   BIOCHEMICAL JOURNAL

Kruppel-like factor 5 is required for perinatal lung morphogenesis and function

(2008) H. Wan et al.   DEVELOPMENT

Acyclic retinoid inhibits functional interaction of transcription factors Krüppel-like factor 5 and retinoic acid receptor-alpha

(2008) Nanae Kada et al.   FEBS LETTERS

Krüppel-Like Factor 5 Mediates Transmissible Murine Colonic Hyperplasia Caused by Citrobacter rodentium Infection

(2008) Beth B. McConnell et al.   GASTROENTEROLOGY

Pro-proliferative Factor KLF5 Becomes Anti-proliferative in Epithelial Homeostasis upon Signaling-mediated Modification

(2008) Peng Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Krüppel-like Factor 5 Causes Cartilage Degradation through Transactivation of Matrix Metalloproteinase 9

(2008) Yusuke Shinoda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Krüppel-like Factor 5 Controls Keratinocyte Migration via the Integrin-linked Kinase

(2008) Yizeng Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMOylation Regulates Nuclear Localization of Krüppel-like Factor 5

(2008) James X. Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A core Klf circuitry regulates self-renewal of embryonic stem cells

(2008) Jianming Jiang et al.   NATURE CELL BIOLOGY

SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-δ

(2008) Yumiko Oishi et al.   NATURE MEDICINE

Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizophrenia

(2008) Masaya Yanagi et al.   SCHIZOPHRENIA RESEARCH

Krüppel-Like Factor 5 Mediates Cellular Transformation During Oncogenic KRAS-Induced Intestinal Tumorigenesis

(2007) Mandayam O. Nandan et al.   GASTROENTEROLOGY