Secukinumab treatment in new-onset psoriasis: aiming to understand the potential for disease modification - rationale and design of the randomized, multicenter STEPIn study

Characterization of disease burden, comorbidities, and treatment use in a large, US-based cohort: Results from the Corrona Psoriasis Registry

(2018) Bruce Strober et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Granzyme A potentiates chemokine production in IL-17-stimulated keratinocytes

(2017) Stanley Cheuk et al.   EXPERIMENTAL DERMATOLOGY

Functional and phenotypic heterogeneity of group 3 innate lymphoid cells

(2017) Felipe Melo-Gonzalez et al.   IMMUNOLOGY

β-Defensin 2 is a responsive biomarker of IL-17A–driven skin pathology in patients with psoriasis

(2017) Frank Kolbinger et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinically resolved psoriatic lesions contain psoriasis-specific IL-17–producing αβ T cell clones

(2017) Tiago R. Matos et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamic Changes in Resident and Infiltrating Epidermal Dendritic Cells in Active and Resolved Psoriasis

(2017) Elisa Martini et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate-to-severe plaque psoriasis up to 1 year: Results from the CLEAR study

(2017) Andrew Blauvelt et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The journey of adult psoriasis patients towards biologics: past and present - Results from the BioCAPTURE registry

(2017) J.M.P.A. van den Reek et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Inflammatory memory sensitizes skin epithelial stem cells to tissue damage

(2017) Shruti Naik et al.   NATURE

Ultraviolet B Phototherapy for Psoriasis: Review of Practical Guidelines

(2016) Dhwani Mehta et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Dermal γδ T cells – What have we learned?

(2015) Rebecca L. O’Brien et al.   CELLULAR IMMUNOLOGY

Real-World Outcome Analysis of Continuously and Intermittently Treated Patients with Moderate to Severe Psoriasis after Switching to a Biologic Agent

(2015) Frida Hjalte et al.   DERMATOLOGY

Skin-resident memory CD4+T cells enhance protection againstLeishmania majorinfection

(2015) Nelson D. Glennie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efficacy and Safety of Systemic Long-Term Treatments for Moderate-to-Severe Psoriasis: A Systematic Review and Meta-Analysis

(2015) Alexander Nast et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe plaque psoriasis: CLEAR, a randomized controlled trial

(2015) Diamant Thaçi et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials

(2015) Christopher E M Griffiths et al.   LANCET

The emerging role of resident memory T cells in protective immunity and inflammatory disease

(2015) Chang Ook Park et al.   NATURE MEDICINE

Resident memory T cells in human health and disease

(2015) R. A. Clark   Science Translational Medicine

Phototherapy in Psoriasis: A Review of Mechanisms of Action

(2015) Tami Wong et al.   JOURNAL OF CUTANEOUS MEDICINE AND SURGERY

Immunology of Psoriasis

(2014) Michelle A. Lowes et al.   Annual Review of Immunology

Comparison of long-term drug survival and safety of biologic agents in patients with psoriasis vulgaris

(2014) R. Gniadecki et al.   BRITISH JOURNAL OF DERMATOLOGY

Early intervention in psoriasis and immune-mediated inflammatory diseases: A hypothesis paper

(2014) G. Girolomoni et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

Epidermal Th22 and Tc17 Cells Form a Localized Disease Memory in Clinically Healed Psoriasis

(2014) S. Cheuk et al.   JOURNAL OF IMMUNOLOGY

Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials

(2014) Richard G. Langley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert

(2014) S. Ariotti et al.   SCIENCE

Efficacy and safety of infliximab as continuous or intermittent therapy in patients with moderate-to-severe plaque psoriasis: results of a randomized, long-term extension trial (RESTORE2)

(2013) K. Reich et al.   BRITISH JOURNAL OF DERMATOLOGY

Reduction of inflammatory slan (6-sulfo LacNAc) dendritic cells in psoriatic skin of patients treated with etanercept

(2013) Claudia Günther et al.   EXPERIMENTAL DERMATOLOGY

Dermal γδ T cells — A new player in the pathogenesis of psoriasis

(2013) Yihua Cai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Sensing and alarm function of resident memory CD8+ T cells

(2013) Jason M Schenkel et al.   NATURE IMMUNOLOGY

Significant delay in the introduction of systemic treatment of moderate to severe psoriasis: a prospective multicentre observational study in outpatients from hospital dermatology departments in France

(2012) A. Maza et al.   BRITISH JOURNAL OF DERMATOLOGY

Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study

(2012) K.A. Papp et al.   BRITISH JOURNAL OF DERMATOLOGY

Old and New: Recent Innovations in Vaccine Biology and Skin T Cells

(2012) Thomas S. Kupper   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Emerging Role of IL-17 in the Pathogenesis of Psoriasis: Preclinical and Clinical Findings

(2012) David A. Martin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Meta-Analysis Derived (MAD) Transcriptome of Psoriasis Defines the “Core” Pathogenesis of Disease

(2012) Suyan Tian et al.   PLoS One

The Multitasking Organ: Recent Insights into Skin Immune Function

(2011) Paola Di Meglio et al.   IMMUNITY

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

(2011) Yihua Cai et al.   IMMUNITY

Gone but Not Forgotten: Lesional Memory in Psoriatic Skin

(2011) Rachael A. Clark   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Subset of Methylated CpG Sites Differentiate Psoriatic from Normal Skin

(2011) Elisha D.O. Roberson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Patients with RA in remission on TNF blockers: when and in whom can TNF blocker therapy be stopped?

(2010) B. Saleem et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease

(2010) Reiko M. Onishi et al.   IMMUNOLOGY

Effective Narrow-Band UVB Radiation Therapy Suppresses the IL-23/IL-17 Axis in Normalized Psoriasis Plaques

(2010) Leanne M. Johnson-Huang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Resolved Psoriasis Lesions Retain Expression of a Subset of Disease-Related Genes

(2010) Mayte Suárez-Fariñas et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

(2010) W. Hueber et al.   Science Translational Medicine

Real-life impact of early interferonβ therapy in relapsing multiple sclerosis

(2009) M. Trojano et al.   ANNALS OF NEUROLOGY

The good initial response to therapy with a combination of traditional disease-modifying antirheumatic drugs is sustained over time: The eleven-year results of the Finnish rheumatoid arthritis combination therapy trial

(2009) Vappu Rantalaiho et al.   ARTHRITIS AND RHEUMATISM

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

Th17 Cytokines Stimulate CCL20 Expression in Keratinocytes In Vitro and In Vivo: Implications for Psoriasis Pathogenesis

(2009) Erin G. Harper et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

European S3-Guidelines on the systemic treatment of psoriasis vulgaris

(2009) D Pathirana et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Clinical and radiological efficacy of initial vs delayed treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis

(2008) S M van der Kooij et al.   ANNALS OF THE RHEUMATIC DISEASES

The prevalence of previously diagnosed and undiagnosed psoriasis in US adults: Results from NHANES 2003-2004

(2008) Shanu Kohli Kurd et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial

(2008) Geert D'Haens et al.   LANCET

Dendritic Cell-Induced Memory T Cell Activation in Nonlymphoid Tissues

(2008) L. M. Wakim et al.   SCIENCE

Adalimumab therapy for moderate to severe psoriasis: A randomized, controlled phase III trial

(2007) Alan Menter et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY