Review
Biology
Beatriz Butron-Bris, Esteban Dauden, Pedro Rodriguez-Jimenez
Summary: Studies have shown that patients with psoriasis may have a higher risk of developing cutaneous malignancies, especially non-melanoma skin cancer (NMSC), compared to those without psoriasis. The reasons for this increased risk are not yet fully understood, but factors such as high dose PUVA therapy, immunosuppressive treatments, and common comorbidities and habits in these patients may play a role in the pathogenesis of these tumors. Periodic screening for skin cancer is recommended for this population.
Article
Biochemistry & Molecular Biology
Aina Akmal Mohd Noor, Maryam Azlan, Norhanani Mohd Redzwan
Summary: Psoriasis is an autoimmune disease mediated by disturbed T cells and other immune cells. The use of biologics to target specific immune components is the most advanced therapy for psoriasis. By inhibiting pro-inflammatory cytokines, cellular signaling can be altered to alleviate cellular inflammation.
Review
Dentistry, Oral Surgery & Medicine
Elodie Courtois, Wafa Bouleftour, Jean-Baptiste Guy, Safa Louati, Rene-Jean Bensadoun, Claire Rodriguez-Lafrasse, Nicolas Magne
Summary: This review discusses the mechanisms of photobiomodulation (PBM) in the prevention and treatment of oral mucositis, focusing on its effects on tumor and healthy cells. There is controversy regarding the carcinogenic effect of PBM, with studies reporting that it may enhance malignant cell proliferation, suggesting a lack of protective effect. More prospective studies are needed to assess the impact of PBM on cancer cells for improving its use in oral mucositis prevention and treatment.
Article
Biochemistry & Molecular Biology
Belen Fatas-Lalana, Joaquin Canton-Sandoval, Lola Rodriguez-Ruiz, Raul Corbalan-Velez, Teresa Martinez-Menchon, Ana B. Perez-Oliva, Victoriano Mulero
Summary: A retrospective study in a Spanish cohort of 200 psoriasis patients and 100 healthy donors investigated the comorbidities associated with psoriasis and their impact on phototherapy response. The study found a higher incidence of various comorbidities in psoriasis patients, particularly in those over 40 years old. Phototherapy was effective in treating moderate-severe psoriasis, with narrow-band ultraviolet B being the most effective type. However, comorbidities such as liver disease, hypertension, heart disease, vascular disease, and diabetes were associated with a lower response to phototherapy. Liver disease and anemia comorbidities were found to favor treatment failure. Additionally, zebrafish and human 3D organotypic models suggested the potential therapeutic benefit of inhibiting GLUT1 and dipeptidyl peptidase 4 for psoriasis. Identifying specific comorbidities is crucial when planning treatment for psoriasis patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Nyshadham S. N. Chaitanya, Arpita Devi, Sibani Sahu, Phaniendra Alugoju
Summary: This review focuses on the multifunctional roles of Trehalose in cancer treatment, highlighting its ability to target various cellular processes and proteins within the cell, with potential therapeutic value against cancer.
Review
Pharmacology & Pharmacy
Wan Azmira Wan Saidin, Ibrahim Jantan, Siti Mariam Abdul Wahab, Juriyati Jalil, Mazlina Mohd Said, Syaratul Dalina Yusoff, Khairana Husain
Summary: The objective of this study is to compile up-to-date data on the pharmacological actions and mechanisms of hypophyllanthin. The compound has shown potential as a lead molecule for drug discovery, especially for inflammatory and immune-related disorders. However, further animal studies are needed to analyze its bioavailability, pharmacokinetics, pharmacodynamics, and toxicity before clinical investigations.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Lin Chen, Jie Li, Ying Yao, Shanlong Wang, Shuangjin Zheng, Xinggang Ju, Bin Zhang
Summary: The study found that after treatment with acitretin, the expression levels of three miRNAs (miR-146a-5p, miR-122-5p, and miR-21-5p) in the plasma of 12 patients with psoriasis vulgaris were significantly decreased. These miRNAs have the potential to serve as molecular markers to evaluate the therapeutic effect of acitretin, with high AUC values. Target genes of the miRNAs were mainly involved in MAPK, JAK-STAT, and NF-kappa B signaling pathways, which were validated through in vitro experiments.
Review
Medicine, Research & Experimental
Ghader Babaei, Shiva Gholizadeh-Ghaleh Aziz, Masoumeh Rajabi Bazl, Mohammad Hassan Khadem Ansari
Summary: Cancer is a major challenge for human societies, with natural products like Alantolactone (ALT) being studied for their anti-cancer properties by inhibiting signaling pathways and generating free radicals. These studies aim to introduce the latest molecular mechanisms of ALT proposed by researchers in recent years.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Dermatology
Alan Menter, Gerald G. Krueger, So Yeon Paek, Dario Kivelevitch, Iannis E. Adamopoulos, Richard G. Langley
Summary: Psoriasis is an immune-mediated inflammatory skin disease associated with inflammatory comorbidities, including increased cardiovascular risk. The IL-23/IL-17 axis plays a central role in the immunopathogenesis of psoriasis and related comorbidities, and selectively inhibiting these cytokines has significant therapeutic benefits for patients with moderate to severe plaque psoriasis.
DERMATOLOGY AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Yaeko Hashimoto, Takuji Suzuki, Kenji Hashimoto
Summary: The ongoing COVID-19 pandemic has sparked interest in drug repurposing, particularly in the use of antidepressants. Clinical data suggest that early-stage COVID-19 patients who take antidepressants may have a lower risk of intubation or death. Fluvoxamine, among antidepressants, is the most attractive drug for mild to moderate COVID-19 cases. Additionally, there may be a possible link between maternal COVID-19 infection and a risk for neuropsychiatric disorders in offspring, such as autism spectrum disorder and schizophrenia.
MOLECULAR PSYCHIATRY
(2022)
Review
Pharmacology & Pharmacy
Qiang Cao, Qi Wang, Xinyan Wu, Qi Zhang, Jinghan Huang, Yuquan Chen, Yanwei You, Yi Qiang, Xufeng Huang, Ronggao Qin, Guangzhu Cao
Summary: Leonurine, an alkaloid found in the aerial portion of a plant in the Labiatae family, has shown significant therapeutic efficacy in the treatment of gynecological disorders and has broad-spectrum antineoplastic capabilities. It exerts its anticancer potential through various mechanisms, including inhibiting neoplastic cell proliferation, inducing apoptosis and autophagy, and suppressing oncogenic cell invasion and migration. Key signal transduction pathways involved in these processes include TRAIL, PI3K/AKT, STAT3, and MAP/ERK.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Ploysyne Rattanakaemakorn, Korn Triyangkulsri, Wimolsiri Iamsumang, Poonkiat Suchonwanit
Summary: A study comparing the efficacy and safety of 308-nm excimer lamp monotherapy and a combination of 308-nm excimer lamp and 10% liquor carbonis detergens in scalp psoriasis treatment found that the combination therapy was more effective in reducing PSSI scores and achieving PSSI75, suggesting that liquor carbonis detergens can enhance the efficacy of excimer lamp treatment in patients with scalp psoriasis.
FRONTIERS IN MEDICINE
(2021)
Review
Engineering, Biomedical
Pezhman Mahmoudi, Mohammad Reza Akbarpour, Hengame Babaei Lakeh, Fengjuan Jing, Mohammad Reza Hadidi, Behnam Akhavan
Summary: Titanium implants are widely used in bone surgery due to their mechanical properties, biological compatibility, and corrosion resistance. However, they are prone to bacterial infection, which can be addressed by incorporating copper into the alloy system. This review provides insight into the mechanisms and engineering strategies behind the antibacterial activity of Ti-Cu implants.
MATERIALS TODAY BIO
(2022)
Review
Dermatology
Megan Mosca, Julie Hong, Edward Hadeler, Nicholas Brownstone, Tina Bhutani, Wilson Liao
Summary: This review highlights the efficacy of various treatment modalities for scalp psoriasis, including topical therapies, phototherapy, systemic agents, and complementary therapy, demonstrating significant improvements in patients' quality of life.
DERMATOLOGY AND THERAPY
(2021)
Review
Materials Science, Multidisciplinary
Jiaozhong Cai, Jiushuai Deng, Liang Wang, Mingzhen Hu, Hongxiang Xu, Xiaoan Hou, Bozeng Wu, Shimei Li
Summary: Ilmenite is an essential mineral for titanium extraction. Flotation has been applied in dressing plants for the recovery of fine ilmenite. The interactions between reagent groups and Ti/Fe sites on the ilmenite surface play a critical role in ilmenite flotation. Activators, mostly metal ions including lead ions, promote ilmenite flotation by increasing active sites on the surface. Combined reagents show better selectivity in ilmenite separation due to their synergistic effect. This study discusses reagent types and action mechanisms in ilmenite flotation and proposes a future outlook based on previous research.
INTERNATIONAL JOURNAL OF MINERALS METALLURGY AND MATERIALS
(2022)
