Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics

The Cardiac Electrophysiology Web Lab

(2016) Jonathan Cooper et al.   BIOPHYSICAL JOURNAL

Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation

(2016) Robert A. Pearlstein et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?

(2016) Ross H. Johnstone et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Uncertainty and variability in computational and mathematical models of cardiac physiology

(2016) Gary R. Mirams et al.   JOURNAL OF PHYSIOLOGY-LONDON

In silico assessment of kinetics and state dependent binding properties of drugs causing acquired LQTS

(2016) William Lee et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Arrhythmia risk stratification of patients after myocardial infarction using personalized heart models

(2016) Hermenegild J. Arevalo et al.   Nature Communications

hERG1 channels drive tumour malignancy and may serve as prognostic factor in pancreatic ductal adenocarcinoma

(2015) E Lastraioli et al.   BRITISH JOURNAL OF CANCER

Uncertainty quantification of fast sodium current steady-state inactivation for multi-scale models of cardiac electrophysiology

(2015) Pras Pathmanathan et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Cell-Specific Cardiac Electrophysiology Models

(2015) Willemijn Groenendaal et al.   PLoS Computational Biology

Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women

(2014) Helena C. Parkington et al.   Nature Communications

hERG channel function: beyond long QT

(2013) Joseph J Babcock et al.   ACTA PHARMACOLOGICA SINICA

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

Wavelet-based protocols for ion channel electrophysiology

(2013) Armin Kargol   BMC Biophysics

Ensuring reliability of safety-critical clinical applications of computational cardiac models

(2013) Pras Pathmanathan et al.   Frontiers in Physiology

High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment

(2012) Giovanni Y. Di Veroli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

MCMC Can Detect Nonidentifiable Models

(2012) Ivo Siekmann et al.   BIOPHYSICAL JOURNAL

Models of Electrical Activity: Calibration and Prediction Testing on the Same Cell

(2012) Maurizio Tomaiuolo et al.   BIOPHYSICAL JOURNAL

hERG K+ Channels: Structure, Function, and Clinical Significance

(2012) Jamie I. Vandenberg et al.   PHYSIOLOGICAL REVIEWS

Models of HERG Gating

(2011) Glenna C.L. Bett et al.   BIOPHYSICAL JOURNAL

MCMC Estimation of Markov Models for Ion Channels

(2011) Ivo Siekmann et al.   BIOPHYSICAL JOURNAL

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

Managing structural uncertainty in health economic decision models: a discrepancy approach

(2011) Mark Strong et al.   JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS

Novel roles for hERG K+ channels in cell proliferation and apoptosis

(2011) J Jehle et al.   Cell Death & Disease

An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk

(2010) CE Pollard et al.   BRITISH JOURNAL OF PHARMACOLOGY

Markov models for ion channels: versatility versus identifiability and speed

(2009) M. Fink et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Using Complicated, Wide Dynamic Range Driving to Develop Models of Single Neurons in Single Recording Sessions

(2008) Kevin H. Hobbs et al.   JOURNAL OF NEUROPHYSIOLOGY