Article
Chemistry, Medicinal
Nissrine Ballout, Agnes Boullier, Walaa Darwiche, Katia Ait-Mohand, Eric Trecherel, Theo Gallego, Cathy Gomila, Linda Yaker, Isabelle Gennero, Jose Kovensky, Jerome Ausseil, Sylvestre Toumieux
Summary: Bone fracture healing is a complex process involving hematoma formation, tissue formation, bony callus formation, and bone remodeling. Current therapeutic strategies for fracture repair include autografts, allografts, and tissue engineering. This study suggests that DP2, a disaccharide compound, may enhance fracture healing by promoting osteoblast differentiation and earlier mineralization in vitro. DP2 might serve as a potential therapeutic candidate for bone fracture repair.
Review
Agriculture, Dairy & Animal Science
Agata Wawrzyniak, Krzysztof Balawender
Summary: This article examines the development, structure, and remodeling of bone tissue. As an essential component of the skeleton, bone provides support and protection and maintains the concentration of calcium and phosphate in body fluids. Bone metabolism involves the balance of bone formation and resorption, regulated by various factors. Secretion of biologically active substances in bone tissue also influences bone function and metabolism.
Article
Biochemistry & Molecular Biology
Hong Chen, Fangfang Song, Fanxin Long
Summary: Glucocorticoids are a common cause for osteoporosis and fractures, but current treatments are not effective due to side effects. This study shows that WNT7B can restore bone mass after glucocorticoid-induced bone loss by increasing osteoblast number and function. However, WNT7B overexpression does not improve abnormal fat accumulation.
Review
Chemistry, Medicinal
Sophia Ogechi Ekeuku, Kok-Lun Pang, Kok-Yong Chih
Summary: Caffeic acid, a metabolite of hydroxycinnamate and phenylpropanoid, acts as an antioxidant to reduce osteoclastogenesis and bone resorption. However, in some cases, it may have no effect on bone resorption or even impair bone mechanical properties in normal rats.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Chemistry, Medicinal
Anirban Sardar, Alisha Ansari, Sampa Gupta, Shradha Sinha, Shubham Pandey, Divya Rai, Mukesh Kumar, Rabi Sankar Bhatta, Ritu Trivedi, Koneni Sashidhara
Summary: A series of compounds were designed and synthesized using molecular hybridization approach. Among them, compound 47 was identified as the most potent osteoanabolic agent, promoting osteogenesis via the non-canonical p38 pathway mediated by RUNX2 and BMP2. It has the potential to be used as a lead for future bone metabolic disorder treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Sumin Lee, Jae-Hyun Kim, Minsun Kim, Sooyeon Hong, Hoyeon Park, Eom Ji Kim, Eun-Young Kim, Chungho Lee, Youngjoo Sohn, Hyuk Sang Jung, Jose Luis Perez-Castrillon
Summary: This study investigated the potential of a natural compound called daucosterol (DC) as a treatment for osteoporosis. The results showed that DC effectively inhibited osteoclast differentiation, promoted osteoblast activity, and prevented bone density loss caused by LPS. These findings suggest that DC may be a new therapeutic alternative for osteoporosis patients in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Yi-Fan Guo, Tian Su, Mi Yang, Chang-jun Li, Qi Guo, Ye Xiao, Yan Huang, Ya Liu, Xiang-Hang Luo
Summary: Autophagy is a crucial intracellular process that recovers nutrients and energy, serving as an anti-aging mechanism. It plays a significant role in cellular homeostasis and is essential in the pathogenesis of bone diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yoon-Hee Cheon, Chang Hoon Lee, Soojin Kim, Gyeong Do Park, Sung Chul Kwak, Hae Joong Cho, Ju-Young Kim, Myeung Su Lee
Summary: Pitavastatin shows potential as a candidate for treating osteoporosis by enhancing osteoblast differentiation and bone growth, as well as inhibiting osteoclast differentiation and bone resorption. Its mechanisms include inhibiting signaling pathways and downregulating transcription factors to regulate osteoclast activity, and stimulating osteoblast differentiation and mineralization to promote bone formation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Yi Wang, Ying Gan, Yuan Dong, Jie Zhou, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: Tax1bp3 is a PDZ domain-containing protein that is overexpressed in cancer and can regulate the differentiation of mesenchymal progenitor cells into osteoblasts and adipocytes. It inhibits osteogenic differentiation and promotes adipogenic differentiation by inhibiting the activation of Wnt/beta-catenin and BMPs/Smads signaling pathways.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Xinwei Chen, Xuzhuo Chen, Rui Chao, Yexin Wang, Yi Mao, Baoting Fan, Yaosheng Zhang, Weifeng Xu, An Qin, Shanyong Zhang
Summary: This study demonstrates the important role of Dlk2 in osteoclast development and bone homeostasis, as well as the interaction between Dlk2 and the Syap1 signaling pathway. The results indicate that Dlk2 deletion inhibits osteoclast formation and leads to a high-bone-mass phenotype, with increased bone mass observed in ovariectomized mice.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Kathryn Frost, Amy J. Naylor, Helen M. McGettrick
Summary: Bone remodelling is a dynamically regulated process involving osteoblasts, osteoclasts, and their progenitors. Dysregulation of bone remodelling can lead to disorders like osteoporosis and Paget's disease. The sphingosine-1-phosphate (S1P) signaling pathway has been identified as an important regulator of bone remodelling and inflammatory responses. This review discusses the role of S1P in bone homeostasis and disease, highlighting its potential as a biomarker and therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yoshimi Niwano, Hidetsugu Kohzaki, Midori Shirato, Shunichi Shishido, Keisuke Nakamura
Summary: Polyphenols, including resveratrol, have antioxidant and anti-inflammatory properties that can regulate the balance between bone formation and resorption, making them a potentially safe and effective treatment for postmenopausal osteoporosis.
Article
Biology
Eunjin Cho, Xiangguo Che, Mary Jasmin Ang, Seongmin Cheon, Jinkyung Lee, Kwang Soo Kim, Chang Hoon Lee, Sang-Yeop Lee, Hee-Young Yang, Changjong Moon, Chungoo Park, Je-Yong Choi, Tae-Hoon Lee
Summary: Peroxiredoxin 5 (Prdx5) plays a significant role in regulating bone resorption and bone formation, and its deficiency leads to osteoporosis. Through immunoprecipitation and LC-MS/MS analysis, hnRNPK was identified as an interacting partner of Prdx5, and Prdx5 negatively regulates the expression of osteocalcin mediated by hnRNPK. Additionally, the loss of Prdx5 enhances the expression of osteoclast-related genes during the differentiation of bone marrow-derived macrophages into multinucleated osteoclasts. These findings suggest that Prdx5 plays an important role in maintaining bone homeostasis by regulating bone cell differentiation.
Article
Biochemistry & Molecular Biology
Liangcong Hu, Xudong Xie, Hang Xue, Tiantian Wang, Adriana C. Panayi, Ze Lin, Yuan Xiong, Faqi Cao, Chengcheng Yan, Lang Chen, Peng Cheng, Kangkang Zha, Yun Sun, Guodong Liu, Chenyan Yu, Yiqiang Hu, Ranyang Tao, Wu Zhou, Bobin Mi, Guohui Liu
Summary: miR-1224-5p is a key regulator of bone osteogenesis, which is associated with fracture healing and osteoporosis development. By targeting ADCY2 and the Rap1 signaling pathway, miR-1224-5p can slow down osteoclast differentiation and promote osteoblast differentiation. In vivo experiments showed that overexpression of miR-1224-5p can promote fracture healing and ameliorate the progression of osteoporosis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Xia Li, Ruisheng Xu, Jun-Xing Ye, Feng-Lai Yuan
Summary: Oral bisphosphonates (BPs) are commonly used for the treatment of osteoporosis. This study found that long-term BP treatment can modulate the expression of specific microRNAs (miRNAs), specifically miR-30a-5p, which is negatively correlated with bone formation. In vitro and in vivo experiments demonstrated that miR-30a-5p inhibits osteoblastic differentiation and bone formation. This research provides important insights into the regulatory mechanisms of long-term BP treatment in postmenopausal osteoporosis.
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)