Article
Pharmacology & Pharmacy
Chen-Mei Chen, Pei-Yu Gung, Yen-Chun Ho, Candra D. D. Hamdin, Shaw-Fang Yet
Summary: This study found that probucol can improve functional recovery and cognitive impairment after traumatic brain injury (TBI) by promoting neuroregeneration and neuronal remodeling. In addition, probucol exerts its neuroregenerative effects by increasing the expression of BDNF and activation of TrkB. Therefore, probucol may be a promising new drug for the treatment of TBI.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Clinical Neurology
Brian E. Powers, Son T. Ton, Robert G. Farrer, Suhani Chaudhary, Russ P. Nockels, Gwendolyn L. Kartje, Shih-Yen Tsai
Summary: This study suggests that anti-Nogo-A antibody treatment may improve functional recovery by promoting axonal growth and neuronal plasticity in individuals with traumatic brain injury. The experiments conducted on rats showed significant improvement in motor deficits after receiving the treatment, indicating the potential efficacy of anti-Nogo-A Ab therapy for patients with TBI.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Neurosciences
Matija Milosevic, Tomoya Nakanishi, Atsushi Sasaki, Akiko Yamaguchi, Taishin Nomura, Milos R. Popovic, Kimitaka Nakazawa
Summary: The study demonstrated that FEST can effectively improve motor function and increase cortical activations in individuals with chronic TBI. Short-term and long-term assessments indicated increased M1 activation after FEST intervention, which remained stable during follow-ups, suggesting a promising rehabilitation approach for TBI patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Orli Thau-Zuchman, Linda Svendsen, Simon C. Dyall, Ursula Paredes-Esquivel, Molly Rhodes, John Priestley, Rene G. Feichtinger, Barbara Kofler, Susanne Lotstra, J. Martin Verkuyl, Robert J. Hageman, Laus M. Broersen, Nick van Wijk, Jose P. Silva, Jordi L. Tremoleda, Adina T. Michael-Titus
Summary: The new ketogenic diet (KD) with a ratio of 2:1 of fat to carbohydrate plus protein showed neuroprotective potential in adult traumatic brain injury (TBI). It significantly improved sensorimotor deficits and spatial memory, reduced lesion size, inflammation, oxidation, and oligodendrocyte loss. The new formulation demonstrated therapeutic potential in adult TBI by enhancing the mTOR pathway and histone modifications.
Review
Biochemistry & Molecular Biology
Alice Jacquens, Edward J. Needham, Elisa R. Zanier, Vincent Degos, Pierre Gressens, David Menon
Summary: Head trauma is a common cause of disability in young adults, and cranial trauma in children has particularities in terms of epidemiology, mechanism, and physiopathology. The long-term repercussions of head trauma can be attributed to chronic neuroinflammation, a complex process involving various actors. Numerous studies have explored different anti-inflammatory therapies for traumatic brain injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Marta Celorrio, Kirill Shumilov, Camryn Payne, Sangeetha Vadivelu, Stuart H. Friess
Summary: This study examined the neuroprotective effects of administering minocycline, an inhibitor of microglial activation, at a clinically feasible time point in a model of TBI plus delayed hypoxemia. Short-course minocycline treatment reduced acute neuronal damage and showed long-term improvements in neurodegeneration, synapse loss, and cognitive performance. Timing and duration of minocycline treatment may play a crucial role in neuroprotection following TBI.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Tiange Chen, Yuguo Xia, Liyang Zhang, Tao Xu, Yan Yi, Jianwei Chen, Ziyuan Liu, Liting Yang, Siming Chen, Xiaoxi Zhou, Xin Chen, Haiyu Wu, Jinfang Liu
Summary: Neural stem cells (NSCs) have potential therapeutic effects in treating traumatic brain injury (TBI) due to their ability to replenish dysfunctional neurons and stimulate neurorestorative processes. However, their efficacy is hindered by low cell retention rates after transplantation into the brain. This study found that cerebrospinal fluid (CSF) flow after TBI is a crucial factor in NSC loss post-transplantation. Hydrogel scaffolds, particularly the GelMA/Alg scaffold, can promote NSC adherence, growth, and differentiation while preventing CSF flow-induced cell loss.
MATERIALS TODAY BIO
(2023)
Review
Pharmacology & Pharmacy
Clement Delage, Toufik Taib, Celia Mamma, Dominique Lerouet, Valerie C. Besson
Summary: Traumatic brain injury (TBI) is a major cause of death and disability worldwide, leading to inflammatory responses, white matter injuries, and neurodegenerative pathologies. The consequences of TBI and pharmacological responses vary with age, emphasizing the need for age-specific approaches in therapy development.
Review
Biochemistry & Molecular Biology
Sana Javaid, Talha Farooq, Zohabia Rehman, Ammara Afzal, Waseem Ashraf, Muhammad Fawad Rasool, Faleh Alqahtani, Sary Alsanea, Fawaz Alasmari, Mohammed Mufadhe Alanazi, Metab Alharbi, Imran Imran
Summary: The increasing incidences of traumatic brain injuries globally due to population growth and reliance on motorized vehicles and machines have resulted in higher socio-economic burden on healthcare systems. Choline-containing phospholipids play a crucial role in TBIs and can be used to evaluate injury severity and mitigate neuro-degradation, serving as a potential biomarker for predicting prognosis. The therapeutic potential of choline phospholipids provides new insights for the management of TBIs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Anesthesiology
Federico Moro, Francesca Fossi, Aurora Magliocca, Rosaria Pascente, Eliana Sammali, Federico Baldini, Daniele Tolomeo, Edoardo Micotti, Giuseppe Citerio, Nino Stocchetti, Francesca Fumagalli, Sandra Magnoni, Roberto Latini, Giuseppe Ristagno, Elisa R. Zanier
Summary: In a mouse model, acute administration of argon gas (iAr) significantly accelerates sensorimotor recovery, improves cognitive deficits, and reduces white matter damage after TBI. iAr also decreases brain edema and neuroinflammation, while increasing ramified cells and the M2-like marker YM1 in microglia.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Clinical Neurology
Ouada Nebie, Kevin Carvalho, Lassina Barro, Liling Delila, Emilie Faivre, Ting-Yi Renn, Ming-Li Chou, Yu-Wen Wu, Ariunjargal Nyam-Erdene, Szu-Yi Chou, Luc Buee, Chaur-Jong Hu, Chih-Wei Peng, David Devos, David Blum, Thierry Burnouf
Summary: TBI causes significant brain anatomopathological damages which can be addressed by a synergistic biotherapy such as human platelet lysate. Its therapeutic potential was tested in in vitro and in vivo TBI models, showing promising results in improving motor function and mitigating neuroinflammation and oxidative stress. The data strongly support that human platelet lysate is a reliable and effective source of neurorestorative factors for brain trauma treatment.
Review
Chemistry, Medicinal
Julio J. Secades
Summary: Citicoline, a neuroprotective drug, has the potential to accelerate recovery of consciousness and improve the outcomes of patients with TBI. It could play a role in the management of TBI with its excellent safety profile.
Review
Biochemistry & Molecular Biology
David Gustafsson, Andrea Klang, Sebastian Thams, Elham Rostami
Summary: BDNF plays a crucial role in neural repair and regeneration, making it a focus of TBI research. Studies have shown varied effects on BDNF expression based on different experimental setups and interventions. Clinical research emphasizes the significance of BDNF polymorphism in outcomes, highlighting its protective role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Chanon Srihagulang, Jirapong Vongsfak, Tanat Vaniyapong, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide, characterized by immediate neuronal destruction and secondary brain injury mechanisms. Vagus nerve stimulation (VNS) shows potential for neuroprotection in TBI through various mechanisms, providing beneficial effects in animal models and patients. Further research is needed to fully understand the therapeutic potential of VNS in treating TBI.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Clinical Neurology
Daniel T. Laskowitz, David W. Van Wyck
Summary: The lack of targeted therapies for traumatic brain injury (TBI) is due to difficulties in animal modeling and clinical trial design. A reverse translational approach that focuses on translating endogenous mechanisms known to influence outcomes after TBI to develop druggable targets is proposed.
Article
Nutrition & Dietetics
Isabell Nessel, Laura De Rooy, Minesh Khashu, Jane L. Murphy, Simon C. Dyall
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2020)
Article
Chemistry, Multidisciplinary
Ines Borges, Patricia C. Henriques, Rita N. Gomes, Artur M. Pinto, Manuel Pestana, Fernao D. Magalhaes, Ines C. Goncalves
Correction
Chemistry, Multidisciplinary
Ines Borges, Patricia C. Henriques, Rita. N. Gomes, Artur M. Pinto, Manuel Pestana, Fernao D. Magalhaes, Ines C. Goncalves
Article
Nutrition & Dietetics
I. Nessel, M. Khashu, S. C. Dyall
Summary: The study found that storage conditions of preterm formula milk do not support in utero accretion rates for LCPUFAs. Although it is clear that powdered formula is more susceptible to lipid peroxidation during refrigeration, specific recommendations still require further research.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2021)
Article
Cell Biology
Tiago L. Laundos, Francisco Vasques-Novoa, Rita N. Gomes, Vasco Sampaio-Pinto, Pedro Cruz, Helder Cruz, Jorge M. Santos, Rita N. Barcia, Perpetua Pinto-do-O, Diana S. Nascimento
Summary: Research indicates that mesenchymal stem cells derived from the umbilical cord show strong potential in treating myocardial infarction by improving cardiac function and limiting adverse cardiac remodeling. While some variability was found among donors, these cell products exhibited similar functionality and transcriptome characteristics in in vitro experiments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell & Tissue Engineering
Rita N. Gomes, Filipa Manuel, Diana S. Nascimento
Summary: Fibrosis is a pathological process characterized by tissue replacement with extracellular matrix, but fibroblasts have been found to play a pro-regenerative role in different organs by maintaining stem cell niches or promoting cell adhesion, migration, and proliferation through secreted molecules.
NPJ REGENERATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Christos F. Kelaiditis, E. Leigh Gibson, Simon C. Dyall
Summary: This study aims to investigate the effects of a high eicosapentaenoic acid multinutrient supplement on anxiety and depression in healthy university students through a randomized double-blind placebo-controlled trial. The primary outcome is improvement in anxiety assessed via the Generalised Anxiety Disorder Assessment-7 scale. The study will last for 24 weeks with participants receiving active treatment or placebo.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2021)
Review
Nutrition & Dietetics
Paul Fairbairn, Simon C. Dyall, Fotini Tsofliou
Summary: There is evidence to suggest that increasing intake of both B vitamins and n-3 PUFA may benefit cognition in older adults. This systematic review found that a combination of n-3 PUFA and B vitamins as part of a multi-nutrient formula improves cognitive function in older adults compared to a placebo.
BRITISH JOURNAL OF NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Simon C. Dyall, Laurence Balas, Nicolas G. Bazan, J. Thomas Brenna, Nan Chiang, Felipe da Costa Souza, Jesmond Dalli, Thierry Durand, Jean-Marie Galano, Pamela J. Lein, Charles N. Serhan, Ameer Y. Taha
Summary: Polyunsaturated fatty acids are important components of cell membranes and play a role in cellular function. They can also serve as precursors for lipid mediators called oxylipins. Oxylipins are formed through enzymatic or non-enzymatic pathways and include eicosanoids and other lipid mediators. This review summarizes current knowledge about the structure and functions of nonclassical oxylipins.
PROGRESS IN LIPID RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Christos F. Kelaiditis, E. Leigh Gibson, Simon C. Dyall
Summary: This study conducted a systematic review and meta-analysis of ten randomized controlled trials with a total of 1426 participants. The results showed that EPA-enriched interventions with proportions > 60% of total EPA + DHA and doses between > 1 g/day and < 2 g/day significantly reduced the severity of depression. However, EPA doses > 2 g/day did not show significant therapeutic effects. The efficacy of EPA, DHA, and DPAn-3 in reducing anxiety severity was uncertain. More high-quality trials are needed to further explore the therapeutic potential of these omega-3 PUFAs.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2023)
Article
Cardiac & Cardiovascular Systems
Luis Raposo, Rui. J. J. Cerqueira, Sara Leite, Liliana Moreira-Costa, Tiago. L. L. Laundos, Joana. O. O. Miranda, Pedro Mendes-Ferreira, Joao Almeida Coelho, Rita. N. N. Gomes, Perpetua Pinto-do-O, Diana. S. S. Nascimento, Andre P. Lourenco, Nuno Cardim, Adelino Leite-Moreira
Summary: This study investigated the efficacy of intracoronary delivery of human umbilical cord matrix-mesenchymal stromal cells (hUCM-MSC) as reperfusion-adjuvant therapy in a translational model of acute myocardial infarction (AMI). The results showed that hUCM-MSC could significantly improve left ventricular systolic function compared to the control group.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Physics, Multidisciplinary
Michael A. Crawford, Andrew J. Sinclair, Yiqun Wang, Walter F. Schmidt, C. Leigh Broadhurst, Simon C. Dyall, Larry Horn, J. Thomas Brenna, Mark R. Johnson
Summary: In George Wald's Nobel Prize acceptance speech, he proposed a hypothesis that docosahexaenoic acid (DHA) traps the energy released during the visual process and carries it to the brain, explaining the previously unresolved issues of information transfer speed and photon wavelength conservation.
Article
Cell Biology
Rui Ribeiro, Joana C. Macedo, Madalena Costa, Vladimir Ustiyan, Anastasia Shindyapina, Alexander Tyshkovskiy, Rita N. Gomes, Jose Pedro Castro, Tanya Kalin, Francisco Vasques-Novoa, Diana S. Nascimento, Sergey E. Dmitriev, Vadim N. Gladyshev, Vladimir V. Kalinichenko, Elsa Logarinho
Summary: The FOXM1 gene plays a crucial role in maintaining cellular homeostasis and has the potential to delay cellular and organismal aging, thereby mitigating aging-related pathologies.
Article
Medicine, Research & Experimental
Orli Thau-Zuchman, Linda Svendsen, Simon C. Dyall, Ursula Paredes-Esquivel, Molly Rhodes, John Priestley, Rene G. Feichtinger, Barbara Kofler, Susanne Lotstra, J. Martin Verkuyl, Robert J. Hageman, Laus M. Broersen, Nick van Wijk, Jose P. Silva, Jordi L. Tremoleda, Adina T. Michael-Titus
Summary: The new ketogenic diet (KD) with a ratio of 2:1 of fat to carbohydrate plus protein showed neuroprotective potential in adult traumatic brain injury (TBI). It significantly improved sensorimotor deficits and spatial memory, reduced lesion size, inflammation, oxidation, and oligodendrocyte loss. The new formulation demonstrated therapeutic potential in adult TBI by enhancing the mTOR pathway and histone modifications.