Journal
NPJ REGENERATIVE MEDICINE
Volume 6, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41536-021-00153-z
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Funding
- European Structural and Investment Funds (ESIF), under Lisbon Portugal Regional Operational Programme
- National Funds through Fundacao para a Ciencia e Tecnologia (FCT) [POCI-01-0145-FEDER-030985, POCI-01-0145-FEDER-031120]
- FCT/Ministerio da Ciencia, Tecnologia e Inovacao [CEECINST/00091/2018, SFRH/BD/144490/2019]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/144490/2019] Funding Source: FCT
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Fibrosis is a pathological process characterized by tissue replacement with extracellular matrix, but fibroblasts have been found to play a pro-regenerative role in different organs by maintaining stem cell niches or promoting cell adhesion, migration, and proliferation through secreted molecules.
Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by large amounts of extracellular matrix, which may lead to organ dysfunction and even death. Fibroblasts are classically associated to fibrosis and tissue repair, and seldom to regeneration. However, accumulating evidence supports a pro-regenerative role of fibroblasts in different organs. While some organs rely on fibroblasts for maintaining stem cell niches, others depend on fibroblast activity, particularly on secreted molecules that promote cell adhesion, migration, and proliferation, to guide the regenerative process. Herein we provide an up-to-date overview of fibroblast-derived regenerative signaling across different organs and discuss how this capacity may become compromised with aging. We further introduce a new paradigm for regenerative therapies based on reverting adult fibroblasts to a fetal/neonatal-like phenotype.
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