Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson’s disease: possible involvement of different binding sites at the PPARγ receptor
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson’s disease: possible involvement of different binding sites at the PPARγ receptor
Authors
Keywords
Cannabinoids, VCE-003.2, PPARγ receptors, Inflammation, Microglial activation, LPS, Parkinson’s disease
Journal
Journal of Neuroinflammation
Volume 15, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-01-16
DOI
10.1186/s12974-018-1060-5
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Neuroinflammation in Synucleinopathies
- (2016) Somin Lim et al. BRAIN PATHOLOGY
- Biological characterization of PM226, a chromenoisoxazole, as a selective CB 2 receptor agonist with neuroprotective profile
- (2016) M. Gómez-Cañas et al. PHARMACOLOGICAL RESEARCH
- Potential of the cannabinoid CB2 receptor as a pharmacological target against inflammation in Parkinson's disease
- (2016) Yolanda Gómez-Gálvez et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- VCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington’s disease
- (2016) Javier Díaz-Alonso et al. Scientific Reports
- Differential upregulation of the cannabinoid CB2 receptor in neurotoxic and inflammation-driven rat models of Parkinson's disease
- (2015) Ruth M. Concannon et al. EXPERIMENTAL NEUROLOGY
- Supplementation of omega 3 fatty acids improves oxidative stress in activated BV2 microglial cell line
- (2015) Lorenzo Corsi et al. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
- The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-γ in human macrophage polarization
- (2015) Gaetano Zizzo et al. Journal of Inflammation-London
- Cannabinoid Signaling and Neuroinflammatory Diseases: A Melting pot for the Regulation of Brain Immune Responses
- (2015) Valerio Chiurchiù et al. Journal of Neuroimmune Pharmacology
- Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications
- (2015) Javier Fernández-Ruiz et al. Neurotherapeutics
- PPARγand the Innate Immune System Mediate the Resolution of Inflammation
- (2015) Amanda Croasdell et al. PPAR Research
- Neuroprotective Properties of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) and its Lipid Ligands
- (2014) Marco Fidaleo et al. CURRENT MEDICINAL CHEMISTRY
- Thiazolidinediones under preclinical and early clinical development for the treatment of Parkinson’s disease
- (2014) Anna R Carta et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- A Cannabigerol Derivative Suppresses Immune Responses and Protects Mice from Experimental Autoimmune Encephalomyelitis
- (2014) Francisco J. Carrillo-Salinas et al. PLoS One
- Rosiglitazone promotes neurite outgrowth and mitochondrial function in N2A cells via PPARgamma pathway
- (2013) Ming-Chang Chiang et al. MITOCHONDRION
- Peroxisome proliferator-activated receptor (PPAR)β/δ, a possible nexus of PPARα- and PPARγ-dependent molecular pathways in neurodegenerative diseases: Review and novel hypotheses
- (2013) Stepan Aleshin et al. NEUROCHEMISTRY INTERNATIONAL
- Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?
- (2012) Javier Fernández-Ruiz et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Pharmacological manipulation of peroxisome proliferator-activated receptor γ (PPARγ) reveals a role for anti-oxidant protection in a model of Parkinson's disease
- (2012) Heather L. Martin et al. EXPERIMENTAL NEUROLOGY
- A Cannabigerol Quinone Alleviates Neuroinflammation in a Chronic Model of Multiple Sclerosis
- (2012) Aitor G. Granja et al. Journal of Neuroimmune Pharmacology
- Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists
- (2012) Marcelo Vizoná Liberato et al. PLoS One
- Ligand and Receptor Dynamics Contribute to the Mechanism of Graded PPARγ Agonism
- (2012) Travis S. Hughes et al. STRUCTURE
- Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ9-THCV in animal models of Parkinson's disease
- (2011) C García et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cannabinoid Receptor Type 1 Protects Nigrostriatal Dopaminergic Neurons against MPTP Neurotoxicity by Inhibiting Microglial Activation
- (2011) Y. C. Chung et al. JOURNAL OF IMMUNOLOGY
- Real-Time PyMOL Visualization for Rosetta and PyRosetta
- (2011) Evan H. Baugh et al. PLoS One
- From Surface to Nuclear Receptors: The Endocannabinoid Family Extends its Assets
- (2010) M. Pistis et al. CURRENT MEDICINAL CHEMISTRY
- The nuclear receptor PPARγ individually responds to serotonin- and fatty acid-metabolites
- (2010) Tsuyoshi Waku et al. EMBO JOURNAL
- Overexpression of CB2 cannabinoid receptors results in neuroprotection against behavioral and neurochemical alterations induced by intracaudate administration of 6-hydroxydopamine
- (2010) Alexander Ternianov et al. NEUROBIOLOGY OF AGING
- Oleamide suppresses lipopolysaccharide-induced expression of iNOS and COX-2 through inhibition of NF-κB activation in BV2 murine microglial cells
- (2010) Young Taek Oh et al. NEUROSCIENCE LETTERS
- WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease
- (2009) David A. Price et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Cannabinoid activation of peroxisome proliferator-activated receptors: Potential for modulation of inflammatory disease
- (2009) S.E. O'Sullivan et al. IMMUNOBIOLOGY
- AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
- (2009) Garrett M. Morris et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice
- (2009) Randy L. Hunter et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Neuroinflammation in Parkinson's disease: a target for neuroprotection?
- (2009) Etienne C Hirsch et al. LANCET NEUROLOGY
- Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
- (2009) Malú G. Tansey et al. NEUROBIOLOGY OF DISEASE
- Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
- (2009) Angelo A. Izzo et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Formyl-methionyl-leucyl-phenylalanine–Induced Dopaminergic Neurotoxicity via Microglial Activation: A Mediator between Peripheral Infection and Neurodegeneration?
- (2008) Xi Gao et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor γ and nuclear factor-κB in macrophages
- (2008) Brian M. Necela et al. IMMUNOLOGY
- Structural basis for the activation of PPARγ by oxidized fatty acids
- (2008) Toshimasa Itoh et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Potential of Peroxisome Proliferator-Activated Receptor Gamma Antagonist Compounds as Therapeutic Agents for a Wide Range of Cancer Types
- (2008) Jack D. Burton et al. PPAR Research
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started