Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation

Regulatory T cells promote myelin regeneration in the central nervous system

(2017) Yvonne Dombrowski et al.   NATURE NEUROSCIENCE

T cells upon activation promote endothelin 1 production in monocytes via IFN-γ and TNF-α

(2017) Shoshi Shinagawa et al.   Scientific Reports

Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2017) Han Gao et al.   Cell Reports

Secondary Progressive Multiple Sclerosis: Definition and Measurement

(2016) Domenico Plantone et al.   CNS DRUGS

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

(2016) Martin Chopra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis

(2016) Alice Valentin-Torres et al.   Journal of Neuroinflammation

Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination

(2016) Pernille M. Madsen et al.   JOURNAL OF NEUROSCIENCE

Astrocytes in multiple sclerosis

(2016) Samuel K Ludwin et al.   Multiple Sclerosis Journal

The pathophysiological role of astrocytic endothelin-1

(2016) Stéphanie Hostenbach et al.   PROGRESS IN NEUROBIOLOGY

Secondary Progression in Multiple Sclerosis: Neuronal Exhaustion or Distinct Pathology?

(2016) Catherine Larochelle et al.   TRENDS IN NEUROSCIENCES

Astrocytes in multiple sclerosis

(2016) Samuel K Ludwin et al.   Multiple Sclerosis Journal

Alternatively Activated (M2) Macrophage Phenotype Is Inducible by Endothelin-1 in Cultured Human Macrophages

(2016) Stefano Soldano et al.   PLoS One

Interleukin-10 is a critical regulator of white matter lesion containment following viral induced demyelination

(2015) Shweta S. Puntambekar et al.   GLIA

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis

(2015) Carine Savarin et al.   Journal of Neuroinflammation

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects

(2015) L. Probert   NEUROSCIENCE

Endothelin-B Receptor Activation in Astrocytes Regulates the Rate of Oligodendrocyte Regeneration during Remyelination

(2015) Timothy R. Hammond et al.   Cell Reports

The Role of Astrocytes in Multiple Sclerosis Progression

(2015) Jorge Correale et al.   Frontiers in Neurology

Tumor necrosis factor-α impairs oligodendroglial differentiation through a mitochondria-dependent process

(2014) M Bonora et al.   CELL DEATH AND DIFFERENTIATION

Tumour necrosis factor-alpha participates on the endothelin-1/nitric oxide imbalance in small arteries from obese patients: role of perivascular adipose tissue

(2014) Agostino Virdis et al.   EUROPEAN HEART JOURNAL

Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis

(2014) Yawei Guo et al.   JOURNAL OF NEUROIMMUNOLOGY

Astrocyte-Derived Endothelin-1 Inhibits Remyelination through Notch Activation

(2014) Timothy R. Hammond et al.   NEURON

Oligodendrogenesis in the normal and pathological central nervous system

(2014) Bilal El Waly et al.   Frontiers in Neuroscience

Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models

(2013) Amanda Boyd et al.   ACTA NEUROPATHOLOGICA

Blockade of tumour necrosis factor-α in experimental autoimmune encephalomyelitis reveals differential effects on the antigen-specific immune response and central nervous system histopathology

(2013) H. Batoulis et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Promoting Remyelination in Multiple Sclerosis—Recent Advances

(2013) E. Jolanda Münzel et al.   DRUGS

Using EAE to better understand principles of immune function and autoimmune pathology

(2013) Manu Rangachari et al.   JOURNAL OF AUTOIMMUNITY

TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment

(2013) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Elevation of Tumor Necrosis Factor Alpha in Dorsal Root Ganglia and Spinal Cord is Associated with Neuroimmune Modulation of Pain in an Animal Model of Multiple Sclerosis

(2013) F. Begum et al.   Journal of Neuroimmune Pharmacology

Different actions of endothelin-1 on chemokine production in rat cultured astrocytes: reduction of CX3CL1/fractalkine and an increase in CCL2/MCP-1 and CXCL1/CINC-1

(2013) Yutaka Koyama et al.   Journal of Neuroinflammation

Pathology and disease mechanisms in different stages of multiple sclerosis

(2013) Hans Lassmann   JOURNAL OF THE NEUROLOGICAL SCIENCES

White matter astrocytes in health and disease

(2013) I. Lundgaard et al.   NEUROSCIENCE

Early Proliferation Does Not Prevent the Loss of Oligodendrocyte Progenitor Cells during the Chronic Phase of Secondary Degeneration in a CNS White Matter Tract

(2013) Sophie C. Payne et al.   PLoS One

Cerebral hypoperfusion in multiple sclerosis is reversible and mediated by endothelin-1

(2013) M. D'haeseleer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling the heterogeneity of multiple sclerosis in animals

(2013) Sarah B. Simmons et al.   TRENDS IN IMMUNOLOGY

Oligodendroglia are limited in type I interferon induction and responsiveness in vivo

(2012) Parul Kapil et al.   GLIA

Progressive multiple sclerosis: pathology and pathogenesis

(2012) Hans Lassmann et al.   Nature Reviews Neurology

IFN-γ Signaling to Astrocytes Protects from Autoimmune Mediated Neurological Disability

(2012) Claudia Hindinger et al.   PLoS One

Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination

(2011) Roberta Brambilla et al.   BRAIN

Astrocytes promote TNF-mediated toxicity to oligodendrocyte precursors

(2010) SunJa Kim et al.   JOURNAL OF NEUROCHEMISTRY

Functions of astrocytes and their potential as therapeutic targets

(2010) Harold K. Kimelberg et al.   Neurotherapeutics

Reactive astrocytes as therapeutic targets for CNS disorders

(2010) Mary E. Hamby et al.   Neurotherapeutics

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Axonal and neuronal pathology in multiple sclerosis: What have we learnt from animal models

(2009) Hans Lassmann   EXPERIMENTAL NEUROLOGY