Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinson’s disease (PD): historical overview and future prospects

The Incidence of Parkinson's Disease: A Systematic Review and Meta-Analysis

(2016) Lauren Hirsch et al.   NEUROEPIDEMIOLOGY

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

(2016) Patrick P. Michel et al.   NEURON

Viral Vectors for Gene Therapy: Translational and Clinical Outlook

(2015) Melissa A. Kotterman et al.   Annual Review of Biomedical Engineering

Modulation of monoamine oxidase (MAO) expression in neuropsychiatric disorders: genetic and environmental factors involved in type A MAO expression

(2015) Makoto Naoi et al.   JOURNAL OF NEURAL TRANSMISSION

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Mitochondrial Alterations by PARKIN in Dopaminergic Neurons Using PARK2 Patient-Specific and PARK2 Knockout Isogenic iPSC Lines

(2015) Atossa Shaltouki et al.   Stem Cell Reports

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Complex molecular regulation of tyrosine hydroxylase

(2014) Izel Tekin et al.   JOURNAL OF NEURAL TRANSMISSION

A vesicular sequestration to oxidative deamination shift in myocardial sympathetic nerves in Parkinson's disease

(2014) David S. Goldstein et al.   JOURNAL OF NEUROCHEMISTRY

Peripheral and cognitive signs: delineating the significance of impaired catecholamine metabolism in Parkinson's disease progression

(2014) Michael F. Salvatore et al.   JOURNAL OF NEUROCHEMISTRY

Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum

(2014) C. Pifl et al.   JOURNAL OF NEUROSCIENCE

Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial

(2014) Stéphane Palfi et al.   LANCET

Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial

(2014) PD MED Collaborative Group   LANCET

The medical treatment of Parkinson disease from James Parkinson to George Cotzias

(2014) Stanley Fahn   MOVEMENT DISORDERS

iPS cell technologies: significance and applications to CNS regeneration and disease

(2014) Hideyuki Okano et al.   Molecular Brain

Isolation of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation

(2014) Daisuke Doi et al.   Stem Cell Reports

Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease

(2013) David S. Goldstein et al.   JOURNAL OF NEUROCHEMISTRY

Aldehyde dehydrogenase 2 in sporadic Parkinson's disease

(2013) Tanja Maria Michel et al.   PARKINSONISM & RELATED DISORDERS

Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman Primate

(2013) Asuka Morizane et al.   Stem Cell Reports

Considerations for measuring iron in post-mortem tissue of Parkinson’s disease patients

(2012) Dominic J. Hare et al.   JOURNAL OF NEURAL TRANSMISSION

Prolonged Maturation Culture Favors a Reduction in the Tumorigenicity and the Dopaminergic Function of Human ESC-Derived Neural Cells in a Primate Model of Parkinson's Disease

(2012) Daisuke Doi et al.   STEM CELLS

Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases

(2011) David S. Goldstein et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

Tyrosine hydroxylase and regulation of dopamine synthesis

(2010) S. Colette Daubner et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Early Addition of Selegiline to L-Dopa Treatment is Beneficial for Patients With Parkinson Disease

(2010) Yoshikuni Mizuno et al.   CLINICAL NEUROPHARMACOLOGY

Human DJ-1-specific Transcriptional Activation of Tyrosine Hydroxylase Gene

(2010) Shizuma Ishikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

The relevance of iron in the pathogenesis of Parkinson’s disease

(2010) Jeswinder Sian-Hülsmann et al.   JOURNAL OF NEUROCHEMISTRY

A Phase I Study of Aromatic L-Amino Acid Decarboxylase Gene Therapy for Parkinson's Disease

(2010) Shin-ichi Muramatsu et al.   MOLECULAR THERAPY

Neuroprotective effects of zonisamide target astrocyte

(2009) Masato Asanuma et al.   ANNALS OF NEUROLOGY

Aromatic l-amino acid decarboxylase-immunoreactive structures in human midbrain, pons, and medulla

(2009) Kunio Kitahama et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines

(2009) A. Nakashima et al.   JOURNAL OF NEURAL TRANSMISSION

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

L-dopa therapy for Parkinson's disease: Past, present, and future

(2009) Toshiharu Nagatsu et al.   PARKINSONISM & RELATED DISORDERS

Catecholaminergic Systems in Stress: Structural and Molecular Genetic Approaches

(2009) Richard Kvetnansky et al.   PHYSIOLOGICAL REVIEWS

Simple Photometric Assay of Dopamine- -Hydroxylase Activity in Human Blood: Useful in Clinical Chemistry

(2008) T. Nagatsu   CLINICAL CHEMISTRY

Results from a phase I safety trial of hAADC gene therapy for Parkinson disease

(2008) J. L. Eberling et al.   NEUROLOGY

Genomic aspects of sporadic Parkinson's disease

(2008) P. Riederer et al.   PARKINSONISM & RELATED DISORDERS