Proteasome-mediated degradation of tyrosine hydroxylase triggered by its phosphorylation: a new question as to the intracellular location at which the degradation occurs

Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells

(2016) Akira Nakashima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Monomeric Species of the Regulatory Domain of Tyrosine Hydroxylase Has a Low Conformational Stability

(2016) José L. Neira et al.   BIOCHEMISTRY

Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication

(2016) Kristijan Ramadan et al.   CHROMOSOMA

Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme

(2016) Maria T. Bezem et al.   Scientific Reports

Dopamine or biopterin deficiency potentiates phosphorylation at 40 Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system

(2015) Ichiro Kawahata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nuclear localization signals for four distinct karyopherin-β nuclear import systems

(2015) Michael Soniat et al.   BIOCHEMICAL JOURNAL

Rotenone decreases intracellular aldehyde dehydrogenase activity: implications for the pathogenesis of Parkinson's disease

(2015) David S. Goldstein et al.   JOURNAL OF NEUROCHEMISTRY

Tyrosine Hydroxylase Is Short-Term Regulated by the Ubiquitin-Proteasome System in PC12 Cells and Hypothalamic and Brainstem Neurons from Spontaneously Hypertensive Rats: Possible Implications in Hypertension

(2015) Nadia A. Longo Carbajosa et al.   PLoS One

Tyrosine hydroxylase expression and activity in nigrostriatal dopaminergic neurons of MPTP-treated mice at the presymptomatic and symptomatic stages of parkinsonism

(2014) Elena A. Kozina et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders

(2014) David S. Goldstein et al.   PHARMACOLOGY & THERAPEUTICS

Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights

(2013) Gergely Róna et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Cytoplasmic proteasomes are not indispensable for cell growth in Saccharomyces cerevisiae

(2013) Hikaru Tsuchiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proteasome dynamics

(2013) Cordula Enenkel   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The N-Terminal Sequence of Tyrosine Hydroxylase Is a Conformationally Versatile Motif That Binds 14-3-3 Proteins and Membranes

(2013) Åge Aleksander Skjevik et al.   JOURNAL OF MOLECULAR BIOLOGY

The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase

(2013) Shengnan Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease

(2013) David S. Goldstein et al.   JOURNAL OF NEUROCHEMISTRY

Similar temporal and spatial recruitment of native 19S and 20S proteasome subunits to transcriptionally active chromatin

(2012) F. Geng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-β

(2011) Jonathan F. Soderholm et al.   ACS Chemical Biology

Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme

(2011) Akira Nakashima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

gp130 cytokines stimulate proteasomal degradation of tyrosine hydroxylase via extracellular signal regulated kinases 1 and 2

(2011) Xiao Shi et al.   JOURNAL OF NEUROCHEMISTRY

Nuclear import of an intact preassembled proteasome particle

(2011) Anca F. Savulescu et al.   MOLECULAR BIOLOGY OF THE CELL

Defining the geometry of the two-component proteasome degron

(2011) Tomonao Inobe et al.   Nature Chemical Biology

Modeling of presymptomatic and symptomatic stages of parkinsonism in mice

(2011) M.V. Ugrumov et al.   NEUROSCIENCE

Rad23 escapes degradation because it lacks a proteasome initiation region

(2011) Susan Fishbain et al.   Nature Communications

Molecular characterization of dopamine-derived quinones reactivity toward NADH and glutathione: Implications for mitochondrial dysfunction in Parkinson disease

(2010) Marco Bisaglia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Molecular basis for specificity of nuclear import and prediction of nuclear localization

(2010) Mary Marfori et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Accumulation of phosphorylated tyrosine hydroxylase into insoluble protein aggregates by inhibition of an ubiquitin–proteasome system in PC12D cells

(2009) Ichiro Kawahata et al.   JOURNAL OF NEURAL TRANSMISSION

Angiotensin-(1-7) through AT2receptors mediates tyrosine hydroxylase degradation via the ubiquitin-proteasome pathway

(2009) María A. Lopez Verrilli et al.   JOURNAL OF NEUROCHEMISTRY

Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs

(2009) S. Kosugi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Six Classes of Nuclear Localization Signals Specific to Different Binding Grooves of Importin α

(2008) Shunichi Kosugi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY