Article
Food Science & Technology
Tingting Wang, Lin Zheng, Xiaoling Liu, Mouming Zhao
Summary: Sea cucumber hydrolysates (SCH) showed renoprotective effects in diabetic rats by enhancing antioxidant activity and activating Akt/Nrf2 pathway.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Endocrinology & Metabolism
Wan Zhou, Jie Li, Xiaojing Yuan, Wei Wang, Huanran Zhou, Haoqiang Zhang, Shandong Ye
Summary: UCPCR can be used to evaluate islets beta Cell function in T2DM patients with different renal function status. Patients with eGFR>60 ml center dot min(-1)center dot 1.73 m(-2) showed increased levels of UCPCR, FCP, modified HOMA-IR(CP), and HOMA-islet (CP-DM), as well as decreased concentrations of HbA1C, FPG, and creatinine. It was found that UCPCR was positively correlated with FCP and HOMA-IR(CP) in T2DM patients with different levels of renal function, and a cut-off value of UCPCR <= 1.13 nmol/g had high sensitivity and specificity for identifying severe insulin deficiency in these patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Chan-Hee Moon, Ah-Jun Lee, Hye-Yoon Jeon, Eun-Bin Kim, Kwon -Soo Ha
Summary: Neovascularization is a major issue in the late stages of diabetic retinopathy (DR) leading to blindness, and current anti-DR drugs have limitations. In this study, we explored the use of a proinsulin C-peptide molecule with long-lasting delivery characteristics to prevent retinal neovascularization in PDR. A strategy for ultra-long intraocular delivery of human C-peptide was developed and tested in HRECs and PDR mice, showing promising results in inhibiting hyperglycemia-induced retinal neovascularization.
Article
Chemistry, Multidisciplinary
Hongliang He, Troy A. Halseth, Ling Mei, Chuanhong Shen, Lisha Liu, Anna Schwendeman
Summary: Dyslipidemia plays a crucial role in the progression of diabetic nephropathy (DN). The study developed a renal-targeting therapeutic strategy by modifying synthetic high-density lipoprotein (sHDL) nanodiscs with a kidney targeting ligand and encapsulating a liver X receptor agonist. The modified sHDL effectively reduced dyslipidemia and inflammation, showing promise for future clinical translation in DN treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Peripheral Vascular Disease
Kenan Toprak
Summary: This study found that C-peptide level is an independent predictor of CIN in patients with diabetes. Low levels of C-peptide are associated with a greater risk of CIN.
Article
Pharmacology & Pharmacy
Yan Yang, Haiming Xiao, Zeyuan Lin, Rui Chen, Shanshan Li, Chuting Li, Xiaohong Sun, Ziqing Hei, Wenyan Gong, Heqing Huang
Summary: CKIP-1 plays a nephroprotective role in diabetic nephropathy by regulating inflammation and its down-regulation exacerbates renal inflammatory fibrosis. Src kinase interacts with CKIP-1 and promotes its ubiquitination and protein degradation.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Tadesse Asmamaw Dejenie, Endeshaw Chekol Abebe, Misganaw Asmamaw Mengstie, Mohammed Abdu Seid, Natnael Atnafu Gebeyehu, Getachew Asmare Adella, Gizchew Ambaw Kassie, Amanuel Yosef Gebrekidan, Molalegn Mesele Gesese, Kirubel Dagnaw Tegegne, Denekew Tenaw Anley, Sefineh Fenta Feleke, Melkamu Aderajew Zemene, Anteneh Mengist Dessie, Natnael Moges, Yenealem Solomon Kebede, Berihun Bantie, Dagnew Getnet Adugna
Summary: This study investigated the value of serum cystatin C levels and dyslipidemia in detecting diabetic nephropathy in patients with type 2 diabetes mellitus. The results showed significant lipoprotein abnormalities and increased serum cystatin C levels in type 2 diabetes patients with nephropathy. The study also found a significant correlation between dyslipidemia and serum cystatin C levels. Therefore, serum cystatin C and dyslipidemia may serve as sensitive and non-invasive biomarkers for diabetic nephropathy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Baiyu Feng, Yu Lu, Lin Ye, Lijun Yin, Yingjun Zhou, Anqun Chen
Summary: This study used Mendelian randomization analysis to determine the causal relationship between cystatin C and diabetic nephropathy. The study found that cystatin C is an independent risk factor for diabetic nephropathy in patients with diabetes, regardless of BMI and SBP.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Dong-Yuan Chang, Meng-Rui Li, Xiao-Juan Yu, Su-Xia Wang, Min Chen, Ming-Hui Zhao
Summary: In this study, it was found that compared to proteinuric DN patients, nonproteinuric DN patients had lower frequency of diabetic retinopathy (DR) and better renal outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Rajiv Rana, Jayakumar Manoharan, Anubhuti Gupta, Dheerendra Gupta, Ahmed Elwakiel, Hamzah Khawaja, Sameen Fatima, Silke Zimmermann, Kunal Singh, Saira Ambreen, Ihsan Gadi, Ronald Biemann, Shihai Jiang, Khurrum Shahzad, Shrey Kohli, Berend Isermann
Summary: Diabetic kidney disease (DKD) is a growing pandemic associated with obesity and diabetes mellitus. DKD is now the leading cause of end-stage renal disease and is linked to increased risk of cardiovascular morbidity and mortality. This study demonstrates that the cytoprotective coagulation protease activated protein C (aPC) reduces mitochondrial ROS generation in tubular cells and mitigates renal sterile inflammation in DKD, supporting the potential therapeutic use of aPC in DKD treatment.
Article
Environmental Sciences
Ibrahim M. Alhazza, Hossam Ebaid, Mohamed S. Omar, Iftekhar Hassan, Mohamed A. Habila, Jameel Al-Tamimi, Mohamed Sheikh
Summary: The study found that selenium nanoparticles (SeNPs) have a protective effect against kidney injury in streptozocin-induced diabetic rats, improving symptoms such as polyuria, delayed gestation, and abnormal pancreatic beta-cells.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Daiki Hayashi, Yasuhito Shirai
Summary: The drastic increase in the number of patients with diabetes and its complications is a global issue. Diabetic nephropathy, the leading cause of chronic kidney disease, significantly affects patients' quality of life and medical expenses. The activation of DGK to inhibit PKC activation shows potential therapeutic effect in ameliorating diabetic nephropathy.
Article
Biochemistry & Molecular Biology
Yukihisa Suzuki, Motohiro Kiyosawa
Summary: This study examined the relationship between diabetic retinopathy (DR) and systemic factors in 261 patients with type 2 diabetes. Logistic regression analyses revealed that the duration of diabetes, average and highest HbA1c levels, and grade of diabetic nephropathy (DN) significantly correlated with the development of DR. Additionally, the severity of DR was significantly correlated with the duration of diabetes, average HbA1c level, and severity of DN. Logistic regression analyses also showed a significant correlation between the development of diabetic macular edema (DME) and the grade of DN. DN grade is associated with the development of DR and DME, and decreased renal function predicts the onset of DR.
Article
Cell Biology
Wenting Hou, Lihong Lu, Xue Li, Minli Sun, Minmin Zhu, Changhong Miao
Summary: This study found that c-Myc and KMT5A are involved in regulating IRAK1 expression and contribute to hyperglycemia-mediated endothelial inflammation in diabetic nephropathy. The findings provide insights into the pathogenesis of diabetic nephropathy and potential therapeutic targets.
CELLULAR SIGNALLING
(2022)
Article
Endocrinology & Metabolism
Shanshan Li, Zeyuan Lin, Haiming Xiao, Zhanchi Xu, Chuting Li, Jingran Zeng, Xi Xie, Li Deng, Heqing Huang
Summary: This study investigated the role of Fyn in diabetic nephropathy and its regulatory mechanism. The results showed that Fyn was up-regulated under high glucose conditions and its knockdown reduced oxidative stress, improving diabetic renal fibrosis. On the other hand, Fyn overexpression increased oxidative stress and led to renal damage. Mechanistically, Fyn facilitated the degradation of Sirt1 by promoting its ubiquitination, impairing the antioxidant effects of Foxo3a.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Public, Environmental & Occupational Health
Christopher A. Martin, David R. Jenkins, Prashanth Patel, Charles Goss, Arthur Price, Linda Barton, Pankaj Gupta, Francesco Zaccardi, Nigel J. Brunskill, Pranab Haldar, Kamlesh Khunti, Manish Pareek
Summary: In the context of high community transmission rates in Leicester, voluntary testing of asymptomatic healthcare workers showed low uptake and yield, suggesting the need to reconsider its premise and cost-effectiveness.
JOURNAL OF PUBLIC HEALTH
(2022)
Article
Transplantation
Rupert W. Major, David Shepherd, James F. Medcalf, Gang Xu, Laura J. Gray, Nigel J. Brunskill
Summary: South Asian individuals with chronic kidney disease are younger and have more advanced disease compared to White individuals, with a higher risk of end-stage renal disease but a lower mortality rate. Specific interventions tailored to the South Asian population, including the use of the CKD-EPI-PK formula, should be considered.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Cardiac & Cardiovascular Systems
Susil Pallikadavath, Leah Ashton, Nigel J. Brunskill, James O. Burton, Laura J. Gray, Rupert W. Major
Summary: This study assessed the risks and benefits of aspirin in the primary prevention of cardiovascular disease (CVD) in individuals with chronic kidney disease (CKD). The results showed that aspirin did not significantly reduce the incidence of CVD events, all-cause mortality, coronary heart disease, or stroke in CKD patients. However, it increased the risk of bleeding events.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Physiology
Patrick J. Highton, Daniel S. March, Darren R. Churchward, Charlotte E. Grantham, Hannah M. L. Young, Matthew P. M. Graham-Brown, Seila Estruel, Naomi Martin, Nigel J. Brunskill, Alice C. Smith, James O. Burton, Nicolette C. Bishop
Summary: This study investigated the impact of regular, moderate-intensity intradialytic cycling on circulating microparticles and inflammatory markers in unit-based HD patients. Results showed that six months of exercise did not have any effect on microparticles, cytokines, or chemokines. Further functional assays are needed to confirm these findings.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chelsy L. Cliff, Bethany M. Williams, Christos E. Chadjichristos, Ulrik Mouritzen, Paul E. Squires, Claire E. Hills
Summary: Diabetes is a chronic disease characterized by elevated blood glucose and inflammation, leading to kidney and eye complications. Clinical interventions that can delay and prevent disease progression are in high demand. Connexins, membrane bound proteins that can open under pathological conditions and release danger signals, have shown positive outcomes in models of diabetes complications. Blocking connexin-43 specific hemichannels can improve tissue health and function in diabetic eye and kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Peter W. Horby, Guilherme Pessoa-Amorim, Natalie Staplin, Jonathan R. Emberson, Mark Campbell, Enti Spata, Leon Peto, Nigel J. Brunskill, Simon Tiberi, Victor Chew, Thomas Brown, Hasan Tahir, Beate Ebert, David Chadwick, Tony Whitehouse, Rahuldeb Sarkar, Clive Graham, J. Kenneth Baillie, Buddha Basnyat, Maya H. Buch, Lucy C. Chappell, Jeremy Day, Saul N. Faust, Raph L. Hamers, Thomas Jaki, Edmund Juszczak, Katie Jeffery, Wei Shen Lim, Alan Montgomery, Andrew Mumford, Kathryn Rowan, Guy Thwaites, Marion Mafham, Richard Haynes, Martin J. Landray
Summary: In patients hospitalized with COVID-19, aspirin was not associated with reductions in 28-day mortality or in the risk of progressing to invasive mechanical ventilation or death, but was associated with a small increase in the rate of being discharged alive within 28 days.
Article
Infectious Diseases
Christopher A. Martin, Daniel Pan, George Hills, Deborah Modha, Prashanth Patel, Laura J. Gray, David R. Jenkins, Linda Barton, William Jones, Nigel J. Brunskill, Pranab Haldar, Kamlesh Khunti, Manish Pareek
Summary: This study examined the prognosis of COVID-19 patients from different ethnic groups in the UK between the first and second waves. The findings suggest that in the second wave, mortality risk was lower overall but higher for Black patients compared to White patients. This indicates that risk factors for death in ethnic minority groups may be modifiable.
THERAPEUTIC ADVANCES IN INFECTIOUS DISEASE
(2022)
Article
Endocrinology & Metabolism
Morgan E. Grams, Nigel J. Brunskill, Shoshana H. Ballew, Yingying Sang, Josef Coresh, Kunihiro Matsushita, Aditya Surapaneni, Samira Bell, Juan J. Carrero, Gabriel Chodick, Marie Evans, Hiddo J. L. Heerspink, Lesley A. Inker, Kunitoshi Iseki, Philip A. Kalra, H. Lester Kirchner, Brian J. Lee, Adeera Levin, Rupert W. Major, James Medcalf, Girish N. Nadkarni, David M. J. Naimark, Ana C. Ricardo, Simon Sawhney, Manish M. Sood, Natalie Staplin, Nikita Stempniewicz, Benedicte Stengel, Keiichi Sumida, Jamie P. Traynor, Jan van den Brand, Chi-Pang Wen, Mark Woodward, Jae Won Yang, Angela Yee-Moon Wang, Navdeep Tangri
Summary: This study aims to predict adverse kidney outcomes and improve medical management and clinical trial design. By developing and validating models using various factors, the risk of a significant decline in glomerular filtration rate or kidney failure can be successfully predicted. These models are applicable to individuals with or without diabetes, as well as those with high or low eGFR.
Article
Medicine, General & Internal
Valentijn M. T. de Jong, Rebecca Z. Rousset, Neftali Eduardo Antonio-Villa, Arnoldus G. Buenen, Ben Van Calster, Omar Yaxmehen Bello-Chavolla, Nigel J. Brunskill, Vasa Curcin, Johanna A. A. Damen, Carlos A. Fermin-Martinez, Luisa Fernandez-Chirino, Davide Ferrari, Robert C. Free, Rishi K. Gupta, Pranabashis Haldar, Pontus Hedberg, Steven Kwasi Korang, Steef Kurstjens, Ron Kusters, Rupert W. Major, Lauren Maxwell, Rajeshwari Nair, Pontus Naucler, Tri-Long Nguyen, Mahdad Noursadeghi, Rossana Rosa, Felipe Soares, Toshihiko Takada, Florien S. van Royen, Maarten van Smeden, Laure Wynants, Martin Modrak, Folkert W. Asselbergs, Marijke Linschoten, Karel G. M. Moons, Thomas P. A. Debray
Summary: This study externally validated various prognostic models and scoring rules for predicting short term mortality in COVID-19 patients. The results showed significant differences in the predictive abilities of the models and the need for recalibration before implementation in routine care.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Kunihiro Matsushita, Stephen Kaptoge, Steven H. J. Hageman, Yingying Sang, Shoshana H. Ballew, Morgan E. Grams, Aditya Surapaneni, Luanluan Sun, Johan Arnlov, Milica Bozic, Hermann Brenner, Nigel J. Brunskill, Alex R. Chang, Rajkumar Chinnadurai, Massimo Cirillo, Adolfo Correa, Natalie Ebert, Kai Uwe Eckardt, Ron T. Gansevoort, Orlando Gutierrez, Farzad Hadaegh, Jiang He, Shih Jen Hwang, Tazeen H. Jafar, Simerjot K. Jassal, Takamasa Kayama, Csaba P. Kovesdy, Gijs W. Landman, Andrew S. Levey, Donald M. Lloyd-Jones, Rupert W. Major, Katsuyuki Miura, Paul Muntner, Girish N. Nadkarni, Christoph Nowak, Takayoshi Ohkubo, Michelle J. Pena, Kevan R. Polkinghorne, Toshimi Sairenchi, Elke Schaeffner, Markus P. Schneider, Varda Shalev, Michael G. Shlipak, Marit D. Solbu, Nikita Stempniewicz, James Tollitt, Jose M. Valdivielso, Joep van der Leeuw, Angela Yee Moon Wang, Chi Pang Wen, Mark Woodward, Kazumasa Yamagishi, Hiroshi Yatsuya, Luxia Zhang, Jannick A. N. Dorresteijn, Emanuele Di Angelantonio, Frank L. J. Visseren, Lisa Pennells, Josef Coresh
Summary: This study developed an "Add-on" method to incorporate chronic kidney disease (CKD) measures into cardiovascular disease (CVD) risk prediction algorithms, which improved the predictive accuracy. This approach will assist clinicians and patients in more precise risk assessment and personalized preventive therapies for CKD.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Engineering, Biomedical
Eleftherios Siamantouras, Charlie Woodrow, Emine Celiker, Darron A. Cullen, Claire E. Hills, Paul E. Squires, Fernando Montealegre-Z
Summary: This study introduces a new Atomic Force Microscopy Force Spectroscopy (AFM-FS) approach to investigate the mechanical properties of taenidia in bush-crickets. The research reveals that resilin significantly affects the mechanical properties of taenidia fibers, and the distribution of elastic modulus is sensitive to the composition and configuration of resilin and chitin. The findings suggest a sophisticated evolution of taenidia fibers with elasticity playing a crucial role in optimization.
ACTA BIOMATERIALIA
(2022)
Article
Health Care Sciences & Services
Claire Blackmore, Gareth W. W. Hall, Rebecca C. C. Allsopp, Anna L. L. Hansell, Caroline M. M. Cowley, Ruth C. C. Barber, Christopher W. W. Holmes, Martin D. D. Tobin, Jacqui A. A. Shaw, Nigel J. J. Brunskill, Philip N. N. Baker
Summary: This study aims to investigate the effectiveness of setting up and implementing a COVID-19 testing program using RT-LAMP technology and quantify the prevalence of asymptomatic infection on a university campus. The results show that it is possible to rapidly establish a universal testing program for COVID-19 using RT-LAMP testing in collaboration with local healthcare providers. The positive results were comparable to those in the local population, though with a different peak of infection.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Patrick B. Mark, Juan J. Carrero, Kunihiro Matsushita, Yingying Sang, Shoshana H. Ballew, Morgan E. Grams, Josef Coresh, Aditya Surapaneni, Nigel J. Brunskill, John Chalmers, Lili Chan, Alex R. Chang, Rajkumar Chinnadurai, Gabriel Chodick, Massimo Cirillo, Dick de Zeeuw, Marie Evans, Amit X. Garg, Orlando M. Gutierrez, Hiddo J. L. Heerspink, Gunnar H. Heine, William G. Herrington, Junichi Ishigami, Florian Kronenberg, Jun Young Lee, Adeera Levin, Rupert W. Major, Angharad Marks, Girish N. Nadkarni, David M. J. Naimark, Christoph Nowak, Mahboob Rahman, Charumathi Sabanayagam, Mark Sarnak, Simon Sawhney, Markus P. Schneider, Varda Shalev, Jung-Im Shin, Moneeza K. Siddiqui, Nikita Stempniewicz, Keiichi Sumida, Jose M. Valdivielso, Jan van den Brand, Angela Yee-Moon Wang, David C. Wheeler, Lihua Zhang, Frank L. J. Visseren, Benedicte Stengel
Summary: This study investigated the association between cardiovascular disease (CVD) and future risk of kidney failure with replacement therapy (KFRT). It found that both prevalent and incident CVD were strongly associated with KFRT risk, with incident HF showing the strongest association.
EUROPEAN HEART JOURNAL
(2023)
Article
Urology & Nephrology
Morgan E. Grams, Nigel J. Brunskill, Shoshana H. Ballew, Yingying Sang, Josef Coresh, Kunihiro Matsushita, Aditya Surapaneni, Samira Bell, Juan J. Carrero, Gabriel Chodick, Marie Evans, Hiddo J. L. Heerspink, Lesley A. Inker, Kunitoshi Iseki, Philip A. Kalra, H. Lester Kirchner, Brian J. Lee, Adeera Levin, Rupert W. Major, James Medcalf, Girish N. Nadkarni, David M. J. Naimark, Ana C. Ricardo, Simon Sawhney, Manish M. Sood, Natalie Staplin, Nikita Stempniewicz, Benedicte Stengel, Keiichi Sumida, Jamie P. Traynor, Jan van den Brand, Chi-Pang Wen, Mark Woodward, Jae Won Yang, Angela Yee-Moon Wang, Navdeep Tangri
Summary: The kidney failure risk equation (KFRE) accurately predicts kidney failure risk in people with GFR < 60 ml/min per 1.73 m(2) when using the CKD-EPI 2021 creatinine equation. Other modifications to the KFRE did not improve its performance.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Immunology
Yuanyuan Wu, Lili Huang, Weili Sai, Fei Chen, Yu Liu, Cheng Han, Joanna M. Barker, Zinah D. Zwaini, Mark P. Lowe, Nigel J. Brunskill, Bin Yang
Summary: The regulation of neutrophil phagocytosis in renal ischemia-reperfusion (IR) injury by properdin and innate repair receptor is still unknown. A peptide derived from erythropoietin receptor (EPOR) and beta common receptor (beta cR) can improve functional and structural damage in both wild-type and properdin knockout mice. This study demonstrates that the peptide can enhance the phagocytic function of tubular epithelial cells and promote kidney repair through upregulation of EPOR/beta cR triggered by IR and properdin deficiency.
FRONTIERS IN IMMUNOLOGY
(2023)
