Article
Multidisciplinary Sciences
Mingchen Xu, Chenghe Zhao, Haiming Song, Chunmei Wang, He Li, Xudong Qiu, He Jing, Wenyue Zhuang
Summary: The ingredient Sch C in schisandra has been found to have significant therapeutic effects on pulmonary fibrosis by reducing extracellular matrix accumulation and inhibiting the production of lysyl oxidase. This study provides valuable insights into the pathogenesis of pulmonary fibrosis and potential therapeutic approaches.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Kim Santerre, Sergio Cortez Ghio, Stephanie Proulx
Summary: The study found that TGF-beta 2 can promote cell-cell and cell-substrate adhesion in corneal endothelial cells, enhance barrier integrity establishment, and improve CEC functionality.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Cell Biology
Tim Hammersen, Justyna Buchert, Severin Zietzschmann, Solvig Diederichs, Wiltrud Richter
Summary: Increasing extracellular calcium levels can enhance cartilage neogenesis from human articular chondrocytes and bone marrow-derived mesenchymal stromal cells, but the effect is opposite for the two cell types.
Article
Cardiac & Cardiovascular Systems
Andreas Edsfeldt, Pratibha Singh, Frank Matthes, Christoffer Tengryd, Michele Cavalera, Eva Bengtsson, Pontus Duner, Petr Volkov, Glykeria Karadimou, Anton Gistera, Marju Orho-Melander, Jan Nilsson, Jiangming Sun, Isabel Goncalves
Summary: This study investigated the association of TGF-beta 1, 2, and 3 isoforms with plaque stability in atherosclerosis. The results showed that TGF-beta 2 is the most abundant isoform in human plaques and may maintain plaque stability by reducing inflammation and matrix degradation.
CARDIOVASCULAR RESEARCH
(2023)
Article
Chemistry, Physical
Whee-Soo Kim, Sungjin Min, Su Kyeom Kim, Sunghwi Kang, Soohwan An, Ernesto Criado-Hidalgo, Hunter Davis, Avinoam Bar-Zion, Dina Malounda, Yu Heun Kim, Jae-Hyun Lee, Soo Han Bae, Jin Gu Lee, Minsuk Kwak, Seung-Woo Cho, Mikhail G. Shapiro, Jinwoo Cheon
Summary: Magneto-gas vesicles (MGVs) are protein nanostructures that combine gas vesicles and magnetic nanoparticles, enabling non-invasive, long-term, and quantitative monitoring of mechanical properties in living tissues. They significantly improve signal strength and detection sensitivity, offering potential for non-invasive imaging of tissue elasticity and applications in disease diagnosis and treatment.
Review
Medicine, Research & Experimental
Xun Ye, Jinhu Li, Zibo Liu, Xue Sun, Daneng Wei, Linjiang Song, Chunjie Wu
Summary: Fibrosis is a disease characterized by excessive accumulation of extracellular matrix, which can lead to organ failure and death. Activated myofibroblasts have been identified as the main cellular elements responsible for the replacement of normal tissues with nonfunctional fibrotic tissue. The transforming growth factor-beta pathway plays a significant role in fibrosis. Although there is no specific drug for fibrosis treatment, various peptides have shown promise in anti-fibrosis therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Mi Zhou, Yuanjun Zhao, Sarah R. Weber, Christopher Gates, Nicholas J. Carruthers, Han Chen, Xiaoming Liu, Hong-Gang Wang, Michael Ford, Matthew T. Swulius, Alistair J. Barber, Stephanie L. Grillo, Jeffrey M. Sundstrom
Summary: The expression of R345W-Fibulin-3 alters the size and cargo of extracellular vesicles (EVs), which are sufficient to enhance cell migration and induce epithelial-mesenchymal transition (EMT) in recipient cells. Transforming growth factor beta (TGF beta) plays a critical role in EV-mediated EMT induction.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Article
Cell Biology
Mi Zhou, Yuanjun Zhao, Sarah R. Weber, Christopher Gates, Nicholas J. Carruthers, Han Chen, Xiaoming Liu, Hong-Gang Wang, Michael Ford, Matthew T. Swulius, Alistair J. Barber, Stephanie L. Grillo, Jeffrey M. Sundstrom
Summary: This study found that the expression of R345W-Fibulin-3 mutation alters the size and cargo of extracellular vesicles (EVs), which are sufficient to enhance cell migration in a TGF beta-dependent manner. These findings suggest that EV-bound TGF beta plays a critical role in inducing epithelial-mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Review
Pharmacology & Pharmacy
Rui Qin, Qian Zhao, Bo Han, Hong-Ping Zhu, Cheng Peng, Gu Zhan, Wei Huang
Summary: Indole alkaloids have diverse biological activities and are important candidate drugs for the treatment of organ fibrosis. Natural indole alkaloids and indole derivatives can alleviate fibrosis through the suppression of inflammatory response and oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Yao Wang, Xiaoyue Xu, Jacqueline E. Marshall, Muxue Gong, Yang Zhao, Kamal Dua, Philip M. Hansbro, Jincheng Xu, Gang Liu
Summary: HAPLN1 is downregulated in CRC patients, and it controls collagen deposition through the TGF-beta signaling pathway to regulate tumor growth. Therefore, increasing HAPLN1 levels may be a novel therapeutic option for CRC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Developmental Biology
Debanjan Mukherjee, Ganesh Wagh, Mayssa H. Mokalled, Zacharias Kontarakis, Amy L. Dickson, Amey Rayrikar, Stefan Gunther, Kenneth D. Poss, Didier Y. R. Stainier, Chinmoy Patra
Summary: The study reveals that the gene ccn2a plays a crucial role in regulating heart regeneration in zebrafish after injury, by promoting cardiomyocyte proliferation and repopulation of damaged tissue. Additionally, Ccn2a enhances the expression of pro-regenerative extracellular matrix genes and inhibits the chemokine receptor gene cxcr3.1 to positively modulate the innate regenerative response of the adult zebrafish heart.
Article
Cell Biology
Wenjun Hu, Hairong Xiong, Zeyuan Ru, Yan Zhao, Yali Zhou, Kairu Xie, Wen Xiao, Zhiyong Xiong, Cheng Wang, Changfei Yuan, Jian Shi, Quansheng Du, Xiaoping Zhang, Hongmei Yang
Summary: Cancer cachexia leads to adipocyte lipolysis mainly through the parathyroid hormone-related protein (PTHrP)-mediated PKA pathway contained in extracellular vesicles (EVs) derived from tumors. Inhibiting PTHrP activity or the PKA signaling pathway can prevent EV-induced lipolysis.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Asfia Soomro, Mohammad Khajehei, Renzhong Li, Kian O'Neil, Dan Zhang, Bo Gao, Melissa MacDonald, Masao Kakoki, Joan C. C. Krepinsky
Summary: TGF beta 1 enhances fibrosis in chronic kidney disease (CKD) by regulating activin A signaling pathways, suggesting activin A as a potential therapeutic target for preventing fibrosis in CKD.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Shuyan Zhu, Huimin Shan, Jianqiao Li, Lijie Pan, Shudan Wang, Jing Zhu, Hui Guo, Fenghua Mi, Xinyi Wu, Kunpeng Pang
Summary: The transdifferentiation of keratocytes into myofibroblasts is a major cause of corneal fibrosis and scarring. In this study, the researchers investigated the role of Hypoxia Inducible Factor (HIF) in corneal fibrosis and found that topical administration of acriflavine (ACF), a drug inhibiting HIF dimerization, significantly inhibited corneal fibrosis in a mouse model. The researchers also demonstrated that ACF suppressed the expression of key markers of myofibroblast differentiation and the production of disorganized extracellular matrix molecules.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Daniel P. Maruri, Krithika S. Iyer, David W. Schmidtke, W. Matthew Petroll, Victor D. Varner
Summary: After injury and refractive surgery, corneal wound healing can lead to fibrotic response, which is related to the differentiation of corneal keratocytes in response to TGF-beta 1. This study investigates how mechanosensing via focal adhesions regulates the stiffness-dependent myofibroblast differentiation of corneal keratocytes treated with TGF-beta 1.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)