Tuning T Cell Signaling Sensitivity Alters the Behavior of CD4+T Cells during an Immune Response

T memory stem cells in health and disease

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Tonic Signals: Why Do Lymphocytes Bother?

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Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells

(2017) Darienne R. Myers et al.   Cell Reports

CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1

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Targeting of cancer neoantigens with donor-derived T cell receptor repertoires

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CD5 Instructs Extrathymic Regulatory T Cell Development in Response to Self and Tolerizing Antigens

(2015) Jacob G. Henderson et al.   IMMUNITY

The TCR's sensitivity to self peptide–MHC dictates the ability of naive CD8+ T cells to respond to foreign antigens

(2014) Ross B Fulton et al.   NATURE IMMUNOLOGY

Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC

(2014) Stephen P Persaud et al.   NATURE IMMUNOLOGY

From “truly naïve” to “exhausted senescent” T cells: When markers predict functionality

(2013) Anis Larbi et al.   CYTOMETRY PART A

T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens

(2013) Judith N. Mandl et al.   IMMUNITY

Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells

(2013) Bruno Martin et al.   Nature Communications

Targeting ion channels for the treatment of autoimmune neuroinflammation

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Selection of Self-Reactive T Cells in the Thymus

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Dynamics of CD4+ T Cell Responses against Listeria monocytogenes

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Sorting Through Subsets

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A voltage-gated sodium channel is essential for the positive selection of CD4+ T cells

(2012) Wan-Lin Lo et al.   NATURE IMMUNOLOGY

Distinct CD4+ helper T cells involved in primary and secondary responses to infection

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The immunomodulatory properties of the CD5 lymphocyte receptor in health and disease

(2011) Gloria Soldevila et al.   CURRENT OPINION IN IMMUNOLOGY

Basal LAT-diacylglycerol-RasGRP1 Signals in T Cells Maintain TCRα Gene Expression

(2011) Evan Markegard et al.   PLoS One

c-Cbl mediated ubiquitylation and regulation of cell surface exposure of CD5

(2010) Dmytro Demydenko   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes

(2010) Gerald Wirnsberger et al.   IMMUNOLOGY AND CELL BIOLOGY

The Importance of LAT in the Activation, Homeostasis, and Regulatory Function of T Cells

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High-affinity T cell receptor differentiates cognate peptide–MHC and altered peptide ligands with distinct kinetics and thermodynamics

(2010) Stephen P. Persaud et al.   MOLECULAR IMMUNOLOGY

Loss of the LAT Adaptor Converts Antigen-Responsive T Cells into Pathogenic Effectors that Function Independently of the T Cell Receptor

(2009) Michael Mingueneau et al.   IMMUNITY

The functional network of ion channels in T lymphocytes

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Agouti C57BL/6N embryonic stem cells for mouse genetic resources

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