Article
Gastroenterology & Hepatology
Lindsey Kennedy, Vik Meadows, Amelia Sybenga, Jennifer Demieville, Lixian Chen, Laura Hargrove, Burcin Ekser, Wasim Dar, Ludovica Ceci, Debjyoti Kundu, Konstantina Kyritsi, Linh Pham, Tianhao Zhou, Shannon Glaser, Fanyin Meng, Gianfranco Alpini, Heather Francis
Summary: The study found that mast cells promote the progression of NAFLD/NASH and inhibiting mast cell activation may be a potential therapeutic strategy for NAFLD/NASH by controlling the miR-144-3p/ALDH1A3 signaling pathway.
Article
Medicine, Research & Experimental
Baohuan Lian, Lijun Cai, Zhaoqiang Zhang, Fen Lin, Zongxi Li, Xiao-kun Zhang, Fuquan Jiang
Summary: This study investigated the effects of Pien Tze Huang (PTH) on NASH mouse models and found that it exerted hepatoprotective effects by improving liver weight, reducing steatosis and fibrosis, and lowering serum levels of ALT and AST. PTH also inhibited the activation of the inflammatory pathway NF-κB, contributing to the improvement of NAFLD.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Shuquan Lv, Zhongyong Zhang, Xiuhai Su, Wendong Li, Xiaoyun Wang, Baochao Pan, Hanzhou Li, Hui Zhang, Yuansong Wang
Summary: Qingrequzhuo capsule (QRQZ), composed of various plant extracts, has been used to treat nonalcoholic steatohepatitis (NASH). This study found that QRQZ reduced lipid accumulation and inflammation in NASH mice by modulating gut microbiota, enhancing gut barrier function, and inhibiting TLR4/NF-kB signaling pathway activation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Microbiology
An-Ming Yang, Chien-Yu Lin, Shih-Hao Liu, Guan-Da Syu, Hao-Jhe Sun, Kuei-Chuan Lee, Han-Chieh Lin, Ming-Chih Hou
Summary: Saccharomyces boulardii (SB), a dietary supplement yeast, has been shown to improve non-alcoholic steatohepatitis (NASH) symptoms by maintaining gut integrity, increasing microbial diversity, and increasing the number of potentially beneficial gut microbiota.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiwei Yuan, Lu Li, Ying Zhang, Rong Ai, Dongdong Li, Yao Dou, Mengmeng Hou, Dandan Zhao, Suxian Zhao, Yuemin Nan
Summary: This study found that heme oxygenase 1 (HO-1) plays an important role in ferroptosis in nonalcoholic steatohepatitis (NASH). HO-1 deficiency exacerbates the pathological manifestations of NASH, while HO-1 overexpression alleviates NASH progression. Mechanistic studies have shown that the NF-κB signaling pathway is associated with ferroptosis in NASH.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Reyes Gamez-Belmonte, Mireia Tena-Garitaonaindia, Cristina Hernandez-Chirlaque, Samir Cordova, Diego Ceacero-Heras, Fermin Sanchez de Medina, Olga Martinez-Augustin
Summary: The study showed that TNAP haplodeficient mice can develop hepatosteatosis similar to that induced by a MCD diet when fed a control diet, but without weight loss, increased ALT levels, or hypoglycemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Yang Xie, Feng Shen, Yafang He, Canjie Guo, Ruixu Yang, Haixia Cao, Qin Pan, Jiangao Fan
Summary: The effect and mechanism of gamma-muricholic acid (gamma-MCA) in improving nonalcoholic steatohepatitis (NASH) were investigated. It was found that gamma-MCA targeted the FXR/SHP/LXR alpha/FASN signaling pathway to inhibit steatosis-induced peroxidative injury and ameliorate NASH. The treatment with gamma-MCA resulted in decreases in hepatic steatosis, lipid peroxidation, peroxidative injury, hepatocyte apoptosis, and NAFLD activity score (NAS).
Article
Chemistry, Analytical
Meng-juan Gong, Cai-yan Zhu, Zhong-jie Zou, Bin Han, Ping Huang
Summary: The study evaluated the beneficial effects and underlying mechanisms of puerarin on MCD diet-induced NASH in mice using metabonomics and gene sequencing. Puerarin improved hepatic steatosis and inflammation in NASH mice by ameliorating metabolic disorders and rebalancing gut flora. The findings provide new insights into NASH pathogenesis and support the use of puerarin as an anti-NASH agent.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Nutrition & Dietetics
Wei Wang, Ting Zhai, Ping Luo, Xiaolei Miao, Junjun Wang, Yong Chen
Summary: The study showed that SIL treatment reduced serum lipids and bile acid levels in MCD mice, while increasing beneficial microorganisms. This alleviative effect may be achieved by influencing the composition of the gut microbiota and regulating the levels of serum lipids and bile acids through the enterohepatic axis.
FRONTIERS IN NUTRITION
(2023)
Review
Endocrinology & Metabolism
Hui Xiang, Dating Sun, Xin Liu, Zhi-Gang She, Yonghong Chen
Summary: This article mainly summarizes the important impact of intestinal microbiota and its metabolites on the development of NASH. A balanced intestinal microbiota contributes to liver homeostasis, while an imbalanced microbiota may lead to NASH. Additionally, recent clinical trials and animal studies on treating NASH by regulating the intestinal microbiota through prebiotics, probiotics, synbiotics, and FMT are briefly discussed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bilian Zhu, Honggui Li, Bangchao Lu, Xinlei Guo, Chiashan Wu, Fen Wang, Qingsheng Li, Linglin Xie, Shannon Glaser, Heather Francis, Gianfranco Alpini, Chaodong Wu
Summary: Indole supplementation alleviates the severity of non-alcoholic steatohepatitis (NASH) by suppressing hepatocyte proinflammatory responses and hepatic stellate cell fibrogenic activation, as well as reducing intestinal proinflammatory responses.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Nouf Aljobaily, Kelsey Krutsinger, Michael J. Viereckl, Raznin Joly, Bridger Menlove, Brexton Cone, Ailaina Suppes, Yuyan Han
Summary: This study demonstrates the therapeutic potential of cannabigerol (CBG), a plant-derived non-psychotropic compound, in reducing hepatic steatosis, fibrosis, and inflammation in Non-Alcoholic Steatohepatitis (NASH). The low dose of CBG alleviated hepatic fibrosis and inflammation, while the high dose of CBG showed enhanced liver damage.
Article
Multidisciplinary Sciences
Min Wang, Lili Li, Jun Qian, Nannan Wang, Jun Bao, Jiangyue Lu, Faming Chen, Yanfen Li, Yangheng Zhang, Fuhua Yan
Summary: In this study, the salivary microbiota from patients with periodontitis was transferred to obese mice induced by high-fat diet to investigate the influence on gut microbiome and liver metabolism. The results showed that periodontitis salivary microbiota altered gut microbiota composition and exacerbated intestinal barrier dysfunction, leading to activation of toll-like receptor 4 signaling and release of pro-inflammatory factors in the liver. Moreover, the upregulation of the tryptophan-kynurenine-AhR signal axis in the liver was associated with aggravated hepatic steatosis and dysregulation of glucolipid metabolism during NAFLD development. This study suggests that periodontitis salivary microbiota may worsen the pathological progression of NAFLD in the context of obesity, with the tryptophan-AhR pathway potentially playing a key role.
Article
Pharmacology & Pharmacy
Xinxue Wang, Jia Luo, Zhuoheng Lu, Shenzhe Fang, Mengxia Sun, Wenjing Luo, Jianwei Shen, Aiming Liu, Hua Ye
Summary: The potential therapeutic effect of fenofibrate (FENO) on non-alcoholic steatohepatitis (NASH) was investigated in mouse models. Treatment with FENO (25 mg/kg BID) significantly reduced hepatic steatosis, inflammation, and fibrosis. This study suggests that FENO may be a potential therapeutic strategy for NASH treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Linda Vanessa Marquez-Quiroga, Jaime Arellanes-Robledo, Veronica Rocio Vasquez-Garzon, Saul Villa-Trevino, Pablo Muriel
Summary: NASH is a major risk factor for HCC, and current experimental models provide valuable tools for studying and evaluating new drugs for chronic liver diseases. These models show promise in replicating liver alterations and promoting liver injury progression, but there is still room for improvement in simulating the progression from NASH to HCC.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yi-Hao Hsu, Sheng-Yi Chen, Sheng-Yang Wang, Jer-An Lin, Gow-Chin Yen
Article
Biochemistry & Molecular Biology
Chuan-Mu Chen, Yu-Tang Tung, Chi-Hsuan Wei, Po-Ying Lee, Wei Chen
Article
Biochemistry & Molecular Biology
Yu-Tang Tung, Pei-Chin Chiang, Ya-Ling Chen, Yi-Wen Chien
Article
Nutrition & Dietetics
Yi-Syuan Lin, Yu-Tang Tung, Yu-Chun Yen, Yi-Wen Chien
Review
Biochemistry & Molecular Biology
Chuan-Mu Chen, Hsiao-Ching Lu, Yu-Tang Tung, Wei Chen
Article
Agricultural Engineering
Sheng-Yi Chen, Guan-Yu Wang, Ji-Hua Lin, Gow-Chin Yen
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Article
Plant Sciences
Guan-Yu Wang, Sheng-Yi Chen, Ying-Yin Chen, Cheng-Jie Hong, Yi-Hao Hsu, Gow-Chin Yen
Summary: The results of this study demonstrated the remarkable gastroprotective effect of 80EETC treatment in vitro and in vivo, including suppressing inflammatory mediator protein levels, improving antiapoptotic ability and wound healing capability, promoting gastric mucosal healing, increasing gut microbiota diversity, and short-chain fatty acid production. These findings are the first to show the powerful protective effect of T. khasianum Clarke leaves against gastric mucosal injury development.
Article
Environmental Sciences
Chia-Hua Chang, Chow-Feng Chiang, Jiunn-Wang Liao, Gow-Chin Yen, Yi-Chen Huang, Shih-Pei Ni, Chia-Chin Chang, Hsin-Tang Lin
Summary: This study proposed a novel dose estimation method to assess mercury content in fish, finding high levels of methylmercury in certain samples. The research revealed potential health risks of methylmercury consumption for women and children.
Article
Agriculture, Multidisciplinary
Jui-Yi Chen, Gow-Chin Yen, Nien-Ting Tsai, Jer-An Lin
Summary: This study evaluated the quality of natural and commercial dark brown sugar products, finding higher total flavonoid content and lower levels of harmful Maillard reaction products in natural DBS compared to commercial DBS, but higher acrylamide content in natural DBS. The study provides useful information for risk-benefit assessment of DBS products, aiding in food safety management.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Microbiology
Jin-Wei Xu, Chen-Chung Liao, Ke-Chang Hung, Zhong-Yao Wang, Yu-Tang Tung, Jyh-Horng Wu
Summary: The study investigated the antifungal activity and mechanism of several long-chain alkyl gallates, finding that octyl gallate (OG) had the best antifungal activity. The mechanism of action may involve surfactant-like properties, inhibition of ATPase activity, mitochondrial dysfunction, and endogenous ROS production. The findings suggest that OG is a potent inhibitor of white-rot fungus, with potential for further structural optimization research and pharmacological investigations.
Article
Food Science & Technology
Jui-Yi Chen, Xin-Wei Chen, Yu-Yu Lin, Gow-Chin Yen, Jer-An Lin
Summary: The study evaluates the use of spectroscopy methods to quickly authenticate the authenticity and quality of dark brown sugar using chemical technology. Results show that three-dimensional fluorescence spectroscopy is an effective method for DBS authentication, helping to reduce food fraud and ensure food safety.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biology
Chen-Chung Liao, Jin-Wei Xu, Wen-Ching Huang, Hung-Chang Chang, Yu-Tang Tung
Summary: Exercise can mitigate atherosclerosis by improving complement system activation and reducing inflammation in the aorta. This study found that exercise intervention had systematic effects on an ApoE knockout atherosclerotic model and high-fat-diet intervention, modulating multiple pathways and proteins associated with cardiovascular disease.
Article
Biochemistry & Molecular Biology
Siao-Ling Fan, Jer-An Lin, Sheng-Yi Chen, Jia-Hong Lin, Hsin-Tang Lin, Ying-Yin Chen, Gow-Chin Yen
Summary: The study showed that extracts of Hsian-tsao and its polysaccharides have positive effects on impaired wound healing in diabetic individuals. They inhibit glycation and ROS production, restore impaired healing factors, and enhance phagocytosis of bacteria by macrophages, ultimately promoting wound healing.
Review
Food Science & Technology
Gow-Chin Yen, Hsin-Lin Cheng, Li-Yu Lin, Shiuan-Chih Chen, Chin-Lin Hsu
JOURNAL OF FOOD AND DRUG ANALYSIS
(2020)
Article
Biochemistry & Molecular Biology
Wei-Ling Yang, Sheng-Yi Chen, Cheng-Ying Ho, Gow-Chin Yen