Models of nonalcoholic steatohepatitis potentiated by chemical inducers leading to hepatocellular carcinoma

Modeling dysbiosis of human NASH in mice: Loss of gut microbiome diversity and overgrowth of Erysipelotrichales

(2021) James K. Carter et al.   PLoS One

Mechanisms of Fibrosis Development in NASH

(2020) Robert F. Schwabe et al.   GASTROENTEROLOGY

Natural history of NASH and HCC

(2020) Francesco Negro   LIVER INTERNATIONAL

Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

(2020) Ze Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipid remodelling in hepatocyte proliferation and hepatocellular carcinoma

(2020) Zoe Hall et al.   HEPATOLOGY

Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content

(2020) Yusuke Sasaki et al.   Scientific Reports

Carbon tetrachloride (CCl4) accelerated development of non-alcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH) in MS-NASH mice fed western diet supplemented with fructose (WDF)

(2020) Guodong Zhang et al.   BMC GASTROENTEROLOGY

Diethylnitrosamine enhances hepatic tumorigenic pathways in mice fed with high fat diet (Hfd)

(2019) A.S. Arboatti et al.   CHEMICO-BIOLOGICAL INTERACTIONS

HNF4α-deficient Fatty Liver Provides a Permissive Environment for Sex-independent Hepatocellular Carcinoma

(2019) Baharan Fekry et al.   CANCER RESEARCH

HIF-2α upregulation mediated by hypoxia promotes NAFLD-HCC progression by activating lipid synthesis via the PI3K-AKT-mTOR pathway

(2019) Jianxu Chen et al.   Aging-US

Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis

(2019) Masahiro Asakawa et al.   Scientific Reports

Non-alcoholic Steatohepatitis is the Fastest Growing Cause of Hepatocellular Carcinoma in Liver Transplant Candidates

(2018) Zobair Younossi et al.   Clinical Gastroenterology and Hepatology

Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis

(2018) Dirk J. van der Windt et al.   HEPATOLOGY

Mutational landscape of a chemically-induced mouse model of liver cancer

(2018) Frances Connor et al.   JOURNAL OF HEPATOLOGY

A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer

(2018) Takuma Tsuchida et al.   JOURNAL OF HEPATOLOGY

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

(2018) Mark A. Febbraio et al.   Cell Metabolism

Mouse models of nonalcoholic steatohepatitis Towards optimization of their relevance to human NASH

(2018) Geoff Farrell et al.   HEPATOLOGY

BET Inhibition Improves NASH and Liver Fibrosis

(2018) Sarah A. Middleton et al.   Scientific Reports

Nonalcoholic fatty liver disease promotes hepatocellular carcinoma through direct and indirect effects on hepatocytes

(2017) Chi Ma et al.   FEBS Journal

Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine

(2016) Norihiro Kishida et al.   BMC GASTROENTEROLOGY

Lipid desaturation - the next step in targeting lipogenesis in cancer?

(2016) Barrie Peck et al.   FEBS Journal

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Choline: An Important Micronutrient for Maximal Endurance-Exercise Performance?

(2016) Jason T. Penry et al.   INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM

The carbon tetrachloride model in mice

(2015) D Scholten et al.   LABORATORY ANIMALS

Epidemiology of Hepatocellular Carcinoma

(2015) Kelly J. Lafaro et al.   Surgical Oncology Clinics of North America

High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma

(2014) Xiao-Yan Duan et al.   BMC GASTROENTEROLOGY

Silencing ofmicroRNA-122is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis

(2014) Yoko Takaki et al.   CANCER SCIENCE

Immune Functions of Serum Amyloid A

(2013) Kari K. Eklund et al.   CRITICAL REVIEWS IN IMMUNOLOGY

A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma

(2013) Masato Fujii et al.   Medical Molecular Morphology

IL-27 Inhibits Hyperglycemia and Pancreatic Islet Inflammation Induced by Streptozotocin in Mice

(2011) Hirokazu Fujimoto et al.   AMERICAN JOURNAL OF PATHOLOGY

Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice

(2011) Y. Takeda et al.   DIABETOLOGIA

Immunohistochemistry in the evaluation of neovascularization in tumor xenografts

(2008) D Wang et al.   BIOTECHNIC & HISTOCHEMISTRY

Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

(2008) Toshiharu Sakurai et al.   CANCER CELL

Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine-initiated early hepatocarcinogenesis in rats

(2008) Yan Wang et al.   INTERNATIONAL JOURNAL OF CANCER

A rodent model of NASH with cirrhosis, oval cell proliferation and hepatocellular carcinoma

(2008) Vicência M.R. de Lima et al.   JOURNAL OF HEPATOLOGY