Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia

Imatinib Changed Everything

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Present and future of molecular monitoring in chronic myeloid leukaemia

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TGF-α and IL-6 plasma levels selectively identify CML patients who fail to achieve an early molecular response or progress in the first year of therapy

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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

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Treatment of Chronic Myelogenous Leukemia by Blocking Cytokine Alterations Found in Normal Stem and Progenitor Cells

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Biological and Therapeutic Impact of Intratumor Heterogeneity in Cancer Evolution

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Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities

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Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations

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Application of single-cell genomics in cancer: promise and challenges

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Advances and Applications of Single-Cell Sequencing Technologies

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RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance

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Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

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Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations

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Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia

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Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

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How deep is enough in single-cell RNA-seq?

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Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex

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Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

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Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes

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European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013

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Myeloproliferative Neoplasia Remodels the Endosteal Bone Marrow Niche into a Self-Reinforcing Leukemic Niche

(2013) Koen Schepers et al.   Cell Stem Cell

Eaf1 and Eaf2 negatively regulate canonical Wnt/ -catenin signaling

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Genotypic and functional diversity of phenotypically defined primitive hematopoietic cells in patients with chronic myeloid leukemia

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Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients

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Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy

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Quantitative assessment of single-cell RNA-sequencing methods

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TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

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Regulation of Hematopoietic Stem Cell Activity by Inflammation

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Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty

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Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia

(2012) Alex Kentsis et al.   NATURE MEDICINE

Fast gapped-read alignment with Bowtie 2

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Highly multiplexed and strand-specific single-cell RNA 5′ end sequencing

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Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment

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IL-6 Controls Leukemic Multipotent Progenitor Cell Fate and Contributes to Chronic Myelogenous Leukemia Development

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Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia

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Hurdles Toward a Cure for CML: The CML Stem Cell

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Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors

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The cancer stem cell: premises, promises and challenges

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Resolution of Cell Fate Decisions Revealed by Single-Cell Gene Expression Analysis from Zygote to Blastocyst

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Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial

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Persistent Malignant Stem Cells in del(5q) Myelodysplasia in Remission

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The hematopoietic stem cell in chronic phase CML is characterized by a transcriptional profile resembling normal myeloid progenitor cells and reflecting loss of quiescence

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An Abundance of Ubiquitously Expressed Genes Revealed by Tissue Transcriptome Sequence Data

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Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells

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Model-based Analysis of ChIP-Seq (MACS)

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